Synchronous malignancies of ovary, fallopian tube and cervix- A rare case

Kambi, Deepthi P; Mallikarjuna, M; Santosh, C S; Vijayakumar, Abhishek

doi:10.7439/ijbar.v4i9.459

Cited by 10 publications

(8 citation statements)

References 5 publications

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“…There are very few case reports in the literature reporting involvement of three (ovary, endometrium and cervix) or four (ovary, endometrium, cervix and fallopian tube) genital tract organs [5,6]. As such, cervix and ovarian malignancies are very rarely reported [7]. Although the present case is an incidental finding, the aggressive nature of the disease and the pathogenesis of the neoplastic process affecting the tissues with different embryological origins needs further evaluation.…”

Section: Discussionmentioning

confidence: 55%

Aggressive Variety of Synchronous Carcinoma Cervix and Ovary

Rath¹,

Hadi²,

Singhal³

et al. 2017

JCR

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Background: Synchronous malignancies of ovary and cervix are rare and generally entail poor prognosis. The optimal management is not well defined and varies from case to case basis. Case Report: We present a case of synchronous malignancy of cervix and bilateral ovary, which initially masqueraded as a case of malignant ascites pointing towards ovarian carcinoma, but after surgical (total abdominal hysterectomy and bilateral salpingooophorectomy along with omentectomy) and histopathological evaluation was found to be a case of dual malignancy. Patient also received neoadjuvant and adjuvant paclitaxel and carboplatin, followed by full dose whole pelvis radiotherapy. But, the disease was aggressive in nature and progressed rapidly to involve liver, lung and multiple bony sites, inspite of adequate treatment. Conclusion: The possibility of a synchronous malignancy should also be considered while working on genital malignancy.

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Section: Discussionmentioning

confidence: 55%

Aggressive Variety of Synchronous Carcinoma Cervix and Ovary

Rath¹,

Hadi²,

Singhal³

et al. 2017

JCR

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“…It has been proposed that , embryologically similar tissues when simultaneously subjected to either hormones or carcinogens may develop synchronous neoplasms in genetically susceptible individuals. The concept of field cancerization [1,3] which was earlier applied for tumours arising from head and neck region has being applied to the synchronous tumours of female genital tract. Here the repeated exposure of the mucosa of the female genital tract to multiple risk factors leads to the development of multicentric disease .…”

Section: Discussionmentioning

confidence: 99%

“…Synchronous primary malignancies of the female genital tract are very rare. The most common combination being ovarian and endometrial primary neoplasms [1] .Very few cases of synchronous malignant tumours of endometrium and cervix have been reported in the world literature [2] . The prognosis of these patients depends on the stage of presentation of these malignant tumours.…”

Section: Introductionmentioning

confidence: 99%

Synchronous Primary Carcinoma of Cervix and Endometrium

Madhala

Gouthaman

Narayanan

et al. 2017

APALM

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Introduction: Synchronous primary tumours in the female genital tract are rare. Even rarer are the synchronous tumours involving the cervix and endometrium . We describe a rare case of cervical squamous cell carcinoma and endometrial endometrioid adenocarcinoma in a 62-yearold woman .Case Report: A 62-year-old female presented with post menopausal bleeding for 4 months duration. Per vaginal examination showed a cervical growth . Magnetic resonance imaging revealed a mass in the cervical region and extension into the body and fundus of the uterine cavity. Radical hysterectomy(Type III hysterectomy) was done. The pathology revealed synchronous occurrence of primary neoplasms of squamous cell carcinoma of the cervix and adenocarcinoma of the endometrium. Conclusion:Synchronous malignancies of endometrium and cervix are rare. Surgical treatment is radical surgery-Type 3 hysterectomy with bilateral pelvic lymph node dissection. The knowledge of occurrence of synchronous primaries is needed to plan appropriate adjuvant treatment.

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“…The overall incidence of synchronous female genital tract malignancies is 0.63%. 1,2 The most frequently observed synchronous neoplasms are those of the ovary together with the endometrium. These constitute 40% of all, and carry a favourable prognosis because of low malignant potential.…”

Section: Introductionmentioning

confidence: 99%

Synchronous mucinous cystadenoma ovary, leiomyoma uterus and mucinous adenocarcinoma cervix infiltrating into uterine leiomyoma: a rare case report

Rawal¹,

Zaheer²,

Yadav³

et al. 2017

Int J Reprod Contracept Obstet Gynecol

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The overall incidence of synchronous female genital tract malignancies is 0.63%. The most frequently observed synchronous neoplasms are those of the ovary together with the endometrium. Cervical and ovarian malignancies are exceedingly rare. We present the case of a female patient who complained of abdominal distention and pain abdomen. A cervical pap smear was performed, and it showed inflammation and atrophic changes. USG abdomen revealed findings consistent with pyometra. Repeated dilatation and curretage for resolving the pyometra was attempted, but it yielded mucinous fluid only. Another USG abdomen was done, which showed a cervical growth. The patient was taken up for staging laparotomy. Per operatively, no growth could be identified in the cervix. However, dense adhesions of the cervix with the bladder were present. A bilateral salpingo-oophorectomy specimen was sent for intraoperative cytology, and showed mucinous cystadenoma, ovary. Further, the completion total hysterectomy specimen was sent for histopathology. Sections showed adenocarcinoma, cervix and leiomyoma, uterus. The cervical adenocarcinoma showed infiltration into the uterine leiomyoma. Thus, we document a very rare case involving a patient who presented with three coexistent tumours involving bilateral ovaries and uterus. To our knowledge, this is the first reported case of the combination. Accurate diagnosis as separate independent primary tumours or as primary tumour associated with its metastasis, and identification the site of origin in secondary tumours has important prognostic implications and is necessary for appropriate staging and treatment.

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Synchronous malignancies of ovary, fallopian tube and cervix- A rare case

Cited by 10 publications

References 5 publications

Aggressive Variety of Synchronous Carcinoma Cervix and Ovary

Aggressive Variety of Synchronous Carcinoma Cervix and Ovary

Synchronous Primary Carcinoma of Cervix and Endometrium

Synchronous mucinous cystadenoma ovary, leiomyoma uterus and mucinous adenocarcinoma cervix infiltrating into uterine leiomyoma: a rare case report

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