Synchronous lung and breast cancer

Macedo, Joana Espiga de

doi:10.5320/wjr.v7.i1.29

Cited by 2 publications

(5 citation statements)

References 7 publications

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“…This is highly significant and investigating the lung lesion further with a histological diagnosis is indicated since more than half are malignant with potential treatment options. A similar case report was published in the World Journal of Respirology in 2017 by de Macedo [2]. It states that synchronous tumors have an incidence of 0.73-11.7%, and their diagnosis is increasing thanks to better diagnostic techniques and longer life expectancy [3,4].…”

Section: Discussionmentioning

confidence: 66%

The relationship between primary breast and primary lung cancer: A case series

Bernard¹

2020

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Introduction: Prior to the initiation of curative treatment, patients with a confirmed breast malignancy undergo staging to assess for the presence of any metastasis. There are instances where instead of metastatic lesions, the patient is diagnosed with a primary lung malignancy. This is identified when the patient is given chemotherapy directed at the breast primary, but the lung lesion does not improve on imaging. Lung biopsy then confirms this diagnosis. Case Series: This case series highlights three such patients who were treated at Mater Dei Hospital, Malta. All three were first diagnosed with the breast malignancy and were later found to have a second primary in the lung. Management of these patients was always through a multidisciplinary team approach, involving the breast surgeons, cardiothoracic surgeons, the oncologist, respiratory physicians, breast and lung specialized radiologists, and the breast care nurses. Relevant literature is also discussed with a focus on synchronous breast and lung malignancies. Conclusion:The main conclusion from this case series is that it would be beneficial if all patients with breast cancer are regularly screened for a lung malignancy/ metastasis by at least a chest X-ray. It is important to keep in mind the link between the two organs and the potential presence of a separate lung primary.

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Section: Discussionmentioning

confidence: 66%

The relationship between primary breast and primary lung cancer: A case series

Bernard¹

2020

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“…The incidence of synchronous breast and lung cancer is rare, affecting less than 0.5% of patients diagnosed with breast cancer ( 2 , 4 ). In recent years, however, the incidence of MPMT has increased due to advancements in diagnostic modalities, access to health care, genetic predisposition, and longer life expectancy ( 3 ). Additional risk factors such as unhealthy lifestyle, cancer treatments, or interactions between any of these factors have also contributed to the development of MPTP ( 5 ).…”

Section: Discussionmentioning

confidence: 99%

“…Females with breast cancer who are discovered with pulmonary nodules have been observed to exhibit primary lung cancer in 55% of cases, metastatic disease in 37% of cases, and benign lesions in eight percent of cases ( 6 ). Therefore, it is recommended to assess the pathology of these lesions, as approximately half of them could potentially be candidates for curative treatment ( 3 , 4 , 7 ). The statistics above signify that a concurrent lung mass in breast cancer patients merits tissue sampling and pathologic diagnosis that plays an essential role in prognostication and treatment planning ( 4 , 6 ).…”

Section: Discussionmentioning

confidence: 99%

“…The patient did not require adjuvant chemotherapy for breast cancer since the Oncotype Dx recurrence score was low-risk. After completion of radiation, she proceeded with four cycles of adjuvant chemotherapy with cisplatin and pemetrexed for stage IIB adenocarcinoma of the left lung ( 3 - 5 ). She was started on immunotherapy, atezolizumab, however, it was stopped after three cycles as she developed lower extremity weakness attributed to toxicity.…”

Section: Case Presentationmentioning

confidence: 99%

“…Multiple primary malignant tumors (MPMTs) are a clinical challenge that refers to the presence of two or more histologically different, malignant tumors that have been diagnosed within 6 months of each other and are not due to metastasis, recurrence, or local spread ( 1 , 2 ). Its incidence ranges from 0.73% to 11.7% ( 3 ).…”

Section: Introductionmentioning

confidence: 99%

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A case report of synchronous breast and lung cancer with three different pathologic diagnoses

Khan,

de la Torre,

Moghaddas

et al. 2024

AME Case Rep

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Background Multiple primary malignant tumors (MPMTs) pose a significant clinical challenge, denoting the occurrence of two or more distinct malignant tumors with differing histological characteristics, all diagnosed within a 6-month timeframe. MPMT is a rare condition and due to the unique treatment requirements for each specific cancer type, it is crucial for healthcare professionals to accurately differentiate between metastatic growth and distinct primary tumors. Case Description In this case report, we present a 41-year-old female patient who received diagnoses of three separate synchronous primary tumors. The patient presented for evaluation of a right breast mass that had been present for 1 year. Initial diagnostic tests, including mammography and ultrasound, did not provide any conclusive results. Subsequent magnetic resonance imaging (MRI) of the breast prompted an ultrasound-guided biopsy which confirmed moderately differentiated invasive ductal carcinoma (IDC). During pre-surgical testing, a suspicious opacity was detected on a chest X-ray, prompting further investigation with a computed tomography (CT) scan of the chest to distinguish between metastatic disease and a potential new primary tumor. Clinical and pathological examinations revealed the presence of bilateral masses originating from two different origins: invasive mucinous pulmonary adenocarcinoma in the left lower lobe and a neuroendocrine carcinoma in the right middle lobe of the lung. Conclusions Cases of this nature present a complex challenge to physicians and underscore the critical importance of maintaining a high level of clinical suspicion to ensure the delivery of high-quality care. Effective management of such patients requires a multidisciplinary collaboration among breast surgeons, thoracic surgeons, and medical and radiation oncologists.

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Synchronous lung and breast cancer

Cited by 2 publications

References 7 publications

The relationship between primary breast and primary lung cancer: A case series

The relationship between primary breast and primary lung cancer: A case series

A case report of synchronous breast and lung cancer with three different pathologic diagnoses

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