Synchronous lobular carcinoma in situ and invasive lobular cancer: Marker or precursor for invasive lobular carcinoma

Wallace, A.S.; Du, Xiang; Hockman, Lukas; Arya, Manoj Kumar; Jeffress, J.; Wang, Z.; Dale, Paul S.

doi:10.1016/j.ejso.2014.04.007

Cited by 12 publications

(8 citation statements)

References 27 publications

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“…Furthermore, in patients diagnosed with ILC, LCIS is often found to be closely associated. For example, in a recent study of 81 patients with ILC, 37 (46 %) had LCIS that was in close proximity to the invasive component [ 24 ]. We ourselves have frequently observed cases in which, on careful histological sectioning, there appears to be myoepithelial layer disruption at discrete foci of LCIS, accompanied by adjacent ILC, raising the possibility that these sections are capturing the transition from in situ to invasive disease (Fig.…”

Section: Lobular Carcinoma In Situ Progressionmentioning

confidence: 99%

Molecular drivers of lobular carcinoma in situ

et al. 2015

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Lobular carcinoma in situ (LCIS) is considered to be a risk factor for the development of invasive breast carcinoma, but it may also be a non-obligate precursor to invasive lobular carcinoma (ILC). Many LCIS lesions do not progress to ILC, and the molecular changes that are necessary for progression from LCIS to ILC are poorly understood. Disruption in the E-cadherin complex is the hallmark of lobular lesions, but other signaling molecules, such as PIK3CA and c-src, are consistently altered in LCIS. This review focuses on the molecular drivers of lobular carcinoma, a more complete understanding of which may give perspective on which LCIS lesions progress, and which will not, thus having immense clinical implications.

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Section: Lobular Carcinoma In Situ Progressionmentioning

confidence: 99%

Molecular drivers of lobular carcinoma in situ

et al. 2015

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“…7 Recently, studies have demonstrated different statistics regarding both the progression of LCIS and its relationship to ILC. 1,[7][8][9] To et al determined the risk for progression to IBC from DCIS to roughly the same as for LCIS 20 years after diagnosis (21.3% and 19.0%, respectively). 7 The incidence of LCIS also increased dramatically since 1978.…”

Section: Discussionmentioning

confidence: 99%

“…L OBULAR CARCINOMA in situ (LCIS) is a noninvasive neoplasm arising in the terminal ducto-lobular units of the breast that is most often observed in younger premenopausal women. 1 In comparison to ductal carcinoma in situ (DCIS), LCIS does not present as a palpable mass and does not typically demonstrate any specific radiographic findings. 2 Consequently, LCIS is usually an incidental finding discovered after biopsy or after resection is completed for another reason.…”

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confidence: 99%

“…2 Consequently, LCIS is usually an incidental finding discovered after biopsy or after resection is completed for another reason. 1 It is well known that DCIS is a precursor for the development of invasive ductal carcinoma (IDC), and DCIS is reported to be present in IDC in at least 40 per cent of cases. The relationship between LCIS and invasive lobular carcinoma (ILC) has not been well studied, but previous studies have demonstrated coexistence as high as 46 per cent.…”

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confidence: 99%

“…The relationship between LCIS and invasive lobular carcinoma (ILC) has not been well studied, but previous studies have demonstrated coexistence as high as 46 per cent. 1 Considering the increased incidence of LCIS, the relationship between LCIS and ILC needs further characterization. This study evaluates the incidence of synchronous LCIS and ILC at our institution.…”

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confidence: 99%

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The Pathologic Finding of Combined Lobular Carcinoma in Situ and Invasive Lobular Cancer May Indicate more than Just a High-Risk Marker Role of Lobular Carcinoma in Situ

Jean-Louis

Masdon

Smith

et al. 2017

The American Surgeon

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For years, lobular carcinoma in situ (LCIS) has been considered a high-risk marker for developing breast cancer. It is well known that ductal carcinoma in situ is a precursor for the development of invasive ductal carcinoma, and ductal carcinoma in situ is reported to be present in invasive ductal carcinoma in at least 40 per cent of cases. A similar relationship between LCIS and invasive lobular carcinoma (ILC) remains in question. This study evaluates the incidence of synchronous LCIS and ILC at our institution. This is a retrospective review of our tumor registry database of women diagnosed with LCIS or ILC from 2000 to 2014. Pathology reports were evaluated to determine the incidence of pure ILC and mixed ILC/LCIS. Those with both LCIS/ILC (mixed group) and those with pure ILC (pure group) were compared for age, surgical intervention, lymph node involvement, tumor size, nuclear grade, and margins between these two groups. A total of 182 women were identified with LCIS, ILC, or mixed LCIS and ILC. There were76 subjects with pure ILC and 90 with mixed LCIS and ILC. The median and age range for each group were 63.6 (range: 40–97) for the mixed and 64.1 (range: 40–86) for pure groups. Tumor size was evaluated for each group and the median tumor size was 2.5 cm (range: 0.1–7.0cm) for the mixed group and 3.0 cm (range: 0.5–12.5 cm) for the pure group. Nodal involvement was present in 35.23 per cent of the mixed group and 46.3 per cent in the pure group. Surgical treatment for each group was similar, with mastectomy being the preferred surgical option over breast conservation therapy in the mixed and pure groups, 67.07 and 64.71 per cent, respectively. Presently, LCIS is considered a marker, or risk factor, for development of future breast cancer. This retrospective study does identify a strong relationship, 54 per cent, between LCIS and ILC at diagnosis. This high percentage of concurrent LCIS and ILC in surgical/ pathological specimens supports the notion that LCIS may in fact have a precursory role in development of invasive lobular carcinoma of the breast. Additional studies to further investigate this relationship between LCIS and ILC, including genomic analysis, are presently underway.

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Malignant Changes

Sonnenschein¹,

Waldherr²

2017

Atlas of Breast Tomosynthesis

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Synchronous lobular carcinoma in situ and invasive lobular cancer: Marker or precursor for invasive lobular carcinoma

Cited by 12 publications

References 27 publications

Molecular drivers of lobular carcinoma in situ

Molecular drivers of lobular carcinoma in situ

The Pathologic Finding of Combined Lobular Carcinoma in Situ and Invasive Lobular Cancer May Indicate more than Just a High-Risk Marker Role of Lobular Carcinoma in Situ

Malignant Changes

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