Synchronous infiltrating ductal carcinoma and primary extramedullary plasmacytoma of the breast

Cao, Shui; Kang, Hong Gang; Liu, Yan Xue; Ren, Xiu Bao

doi:10.1186/1477-7819-7-43

Cited by 9 publications

(8 citation statements)

References 17 publications

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“…To the best of our knowledge, few case reports have been described in the literature with synchronous diagnosis of multiple myeloma and breast cancer. Cao et al reported a case of breast tumor where infiltrating ductal carcinoma of the breast and breast plasmacytoma occurred which was coexistent in the breast tumor on initial presentation and the patient got successfully treated with chemotherapy for breast cancer and radiotherapy for plasmacytoma [ 16 ]. Khalbuss et al reported a case of synchronous diagnosis of multiple myeloma and breast cancer with plasmacytoid morphology on initial presentation [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

Synchronous Diagnosis of Multiple Myeloma, Breast Cancer, and Monoclonal B-Cell Lymphocytosis on Initial Presentation

Vennepureddy

Nehru

Liu

et al. 2016

Case Reports in Oncological Medicine

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The cooccurrence of more than one oncologic illness in a patient can present a diagnostic challenge. Here we report an unusual case of concomitant existence of multiple myeloma, breast cancer, and monoclonal B-cell lymphocytosis on initial presentation. The challenge was to accurately diagnose each disease and stage in order to maximize the therapeutic regimen to achieve cure/remission. Successful management of the patient and increased life expectancy can be achieved by multidisciplinary management and patient-oriented approach in multiple primary malignant synchronous tumors.

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Section: Discussionmentioning

confidence: 99%

Synchronous Diagnosis of Multiple Myeloma, Breast Cancer, and Monoclonal B-Cell Lymphocytosis on Initial Presentation

Vennepureddy

Nehru

Liu

et al. 2016

Case Reports in Oncological Medicine

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“…Simultaneous occurrence of EMP and SCC is rare and has been only occasionally reported at lung, tonsil and breast level [Dasmahapatra, 1986;Junquera, 2009;Cao, 2009]. In addition, Jayagopal et al described a case of SCC of the skin where EMP was evidenced at the margin of the specimen.…”

Section: Discussionmentioning

confidence: 99%

Cutaneous Plasmacytoma Associated with Squamous Cell Carcinoma of the Sacro-Coccygeal Region

Orlandino¹,

Guariglia²,

Tassinari³

et al. 2013

IJCRM

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We describe the case of a patient who received the diagnosis of squamous cell carcinoma of the radio-treated skin of the sacrococcygeal region where an extramedullary plasmacytoma had been identified one year before. We think that the plasmacytoma was born by a malignant transformation of a host-inflammatory reaction to a not-detected epithelial tumor. It can also hypothesized that plasma-cell dyscrasia or post-radiation infiammatory reaction had promoved the squamous cell carcinoma occurrence.

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“…Extraosseous plasmacytomas has been described as a rare complication of carcinoma. To date, only 15 cases of carcinoma complicating EP have been reported in the English literature 3‐17 . In contrast, there is increasing evidence that clonal B cells reacting to tumor‐derived antigens proliferate in the cancer stroma.…”

Section: Introductionmentioning

confidence: 99%

Synchronous clear cell renal cell carcinoma and clonal plasmacytoid cell infiltration: A case report and literature review

Takahara

Satou

Tsuzuki

2020

Pathology International

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Recent studies of tumor microenvironments have revealed that clonal B cells reacting to tumor‐derived antigens play an important role in anti‐tumor immunity. We report a case of a 72‐year‐old Japanese man with a complaint of fever for 1 month. Computed tomography revealed a 48 mm mass in his right kidney. The patient underwent a right nephrectomy and histology revealed clear cell renal cell carcinoma (ccRCC) of Fuhrman Grade 4 with rhabdoid morphology. Focally, marked plasmacytoid cell infiltration was detected in the carcinoma. These plasmacytoid cells were immunohistochemically positive for immunoglobulin (Ig) G, and kappa light chain restriction was confirmed using mRNA in situ hybridization. Programmed death‐ligand 1 (PD‐L1) immunostaining and RNA in situ hybridization of transforming growth factor beta (TGF‐β) revealed that both PD‐L1 and TGF‐β were highly expressed in the area with clonal plasmacytoid cell infiltration. The patient developed bone metastasis 3 months after surgery, and plasmacytoma was not detected during the observation period. We identified a potential link between an immunosuppressive microenvironment and clonal B cell proliferation. The latter posed a differential diagnosis problem between reactive and neoplastic clonal B cell proliferation vis‐à‐vis a plasmacytoma complicating carcinoma.

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Synchronous infiltrating ductal carcinoma and primary extramedullary plasmacytoma of the breast

Abstract: In this case, careful histopathology examination was essential to make the correct diagnosis and therapy for these synchronous lesions. The patient finished chemotherapy and radiotherapy without significant adverse effects.

Cited by 9 publications

References 17 publications

Synchronous Diagnosis of Multiple Myeloma, Breast Cancer, and Monoclonal B-Cell Lymphocytosis on Initial Presentation

Synchronous Diagnosis of Multiple Myeloma, Breast Cancer, and Monoclonal B-Cell Lymphocytosis on Initial Presentation

Cutaneous Plasmacytoma Associated with Squamous Cell Carcinoma of the Sacro-Coccygeal Region

Synchronous clear cell renal cell carcinoma and clonal plasmacytoid cell infiltration: A case report and literature review

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