Synchronous genitourinary lichen sclerosus signals a distinct urinary microbiome profile in men with urethral stricture disease

Cohen, Andrew J.; Gaither, Thomas W.; Srirangapatanam, Sudarshan; Castellanos, Erick R.; Enriquez, Anthony; Fergus, Kirkpatrick B.; Fadrosh, Douglas; Lynch, Susan V.; Mmonu, Nnenaya A.; Breyer, Benjamin N.

doi:10.1007/s00345-020-03198-9

Cited by 15 publications

(4 citation statements)

References 32 publications

(46 reference statements)

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“…12 Differences in urinary microbiota composition between MGLSc patients and healthy controls have also in a separate study. 13 While our case demonstrates similarities with that reported by De Giorgi et al, no urethrocutaneous fistulation was reported in their case. It has been suggested that clitoral piercing induces changes in the periurethral microflora.…”

Section: Case Reportsupporting

confidence: 90%

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Lichen sclerosus following genital piercing

et al. 2022

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Male genital lichen sclerosus (MGLSc) is a chronic inflammatory dermatosis that predominantly affects uncircumcised males. Several aetiological factors have been described, with growing evidence supporting chronic urine exposure of susceptible epithelium being crucial to its pathogenesis. We describe a 45-year-old man with a 2-year history of MGLSc at the site of a urethrocutaneous fistula secondary to a penile piercing. To our knowledge, this is the first documented case of MGLSc occurring at the site of a genital piercing.

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Section: Case Reportsupporting

confidence: 90%

“…12 Differences in urinary microbiota composition between MGLSc patients and healthy controls have also in a separate study. 13…”

Section: Case Reportmentioning

confidence: 99%

Lichen sclerosus following genital piercing

et al. 2022

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“…While this study represents the only study to date of both the balanopreputial microbiota and urinary microbiota, Cohen et al . investigated the urinary microbiota of men with urethral MGLSc and demonstrated a unique microbiota profile in MGLSc compared with controls, with enrichment of the orders Bacillales , Bacteroidales , and Pasteurellales 51 . They did not report any differences in the relative abundance of the order Fusobacteriales .…”

Section: Discussionmentioning

confidence: 95%

Balanopreputial sac and urine microbiota in patients with male genital lichen sclerosus

et al. 2020

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Background Male genital lichen sclerosus (MGLSc) is a chronic inflammatory scarring dermatosis associated with penile carcinoma. The prepuce is pivotal in its etiology. Other proposed etiological factors are the subject of dispute and include occluded urinary exposure, autoimmunity, immunodysregulation, and infectious agents. Objective To determine whether the bacterial microbiota of the balanopreputial sac and urine are associated with MGLSc. Subjects and methods Twenty uncircumcised patients with MGLSc and 20 healthy uncircumcised males were enrolled in a prospective case–control study. Balanopreputial swabs and urine specimens were subjected to 16S rRNA gene amplicon sequencing. Results Microbiota analysis indicated differences between the groups. In the balanopreputial sac, the median relative abundance of Finegoldia spp. was lower (9% [range 0–60%]) in MGLSc patients than in controls (28% [range 0–62%]). Conversely, the median relative abundance of Fusobacterium spp. was higher in MGLSc patients (4% [range 0–41%]) than in controls (0% [range 0–28%]). In the urine, the median relative abundance of Finegoldia spp. was comparable between groups, whereas that of Fusobacterium spp. was higher in MGLSc patients (0% [range 0–18%] vs. 0% [range 0–5%]). There was a strong association between the microbiota composition of the balanopreputial sac and urine in MGLSc. Conclusion Dysbiosis could be involved in the etiopathogenesis of MGLSc. Further studies are required to confirm the association suggested herein and to determine its nature.

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“…In penile cancer, Onywera et al have described a higher a greater relative abundance of Prevotella, Peptinophilus and Dialister and lower relative abundance of Corynebacterium in hrHPV-infected men [67]. Cohen et al found that the urine bacteriome of male LS patients with showed enrichment of Bacillales, Bacteriodales and Pasteurellales [68]. Increased incidence of Epstein-Barr virus (EBV) in LS biopsy tissue has been described in both female (26.5%) and male (37-38.3%) LS patients [69][70][71].…”

Section: Discussionmentioning

confidence: 99%

The Human Vulvar Microbiome: A Systematic Review

et al. 2021

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The link between cancer and the microbiome is a fast-moving field in research. There is little knowledge on the microbiome in ((pre)malignant) conditions of the vulvar skin. This systematic review aims to provide an overview of the literature regarding the microbiome composition of the healthy vulvar skin and in (pre)malignant vulvar disease. This study was performed according to the PRISMA guidelines. A comprehensive, electronic search strategy was used to identify original research articles (updated September 2021). The inclusion criteria were articles using culture-independent methods for microbiome profiling of the vulvar region. Ten articles were included. The bacterial composition of the vulva consists of several genera including Lactobacillus, Corynebacterium, Staphylococcus and Prevotella, suggesting that the vulvar microbiome composition shows similarities with the corresponding vaginal milieu. However, the vulvar microbiome generally displayed higher diversity with commensals of cutaneous and fecal origin. This is the first systematic review that investigates the relationship between microbiome and vulvar (pre)malignant disease. There are limited data and the level of evidence is low with limitations in study size, population diversity and methodology. Nevertheless, the vulvar microbiome represents a promising field for exploring potential links for disease etiology and targets for therapy.

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Synchronous genitourinary lichen sclerosus signals a distinct urinary microbiome profile in men with urethral stricture disease

Cited by 15 publications

References 32 publications

Lichen sclerosus following genital piercing

Lichen sclerosus following genital piercing

Balanopreputial sac and urine microbiota in patients with male genital lichen sclerosus

The Human Vulvar Microbiome: A Systematic Review

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