Synchronous double cancers of primary hepatic adenosquamous carcinoma and hepatocellular carcinoma: report of a case

Abstract

A 76-year-old male was referred for the treatment of liver tumors detected by abdominal computed tomography (CT). Dynamic CT revealed a low-density tumor with an irregularly enhanced rim in the left lateral sector, and a highly enhanced, well-circumscribed tumor in the caudate lobe, accompanied by dilation of the intrahepatic biliary ducts in the left lobe. Preoperative imaging studies led to the diagnosis of double cancers consisting of intrahepatic cholangiocarcinoma and hepatocellular carcinoma (HCC). Left hemihepatectomy with caudate lobectomy was performed. The postoperative course was uneventful. Microscopic evaluation revealed that the tumor in the left lateral sector was adenosquamous carcinoma (ASC), whereas that in the caudate lobe was HCC. This report presents the first case describing the resection of synchronous double cancers of primary hepatic ASC and HCC.

Unresectable primary hepatic adenosquamous carcinoma successfully treated with systemic and transcatheter hepatic arterial injection chemotherapies followed by conversion surgery: a case report and literature review

“…These results are consistent with the poor prognosis of primary hepatic ASC patients after surgery. The clinical information of 19 patients (surgery followed by postoperative adjuvant chemotherapy, surgery and chemotherapy after recurrence, chemotherapy and conversion surgery, systemic chemotherapy alone, and chemoradiation) treated with chemotherapy, including the details of the drugs used is summarized in Table 2 [ 17 , 19 – 21 , 27 – 29 , 36 , 37 , 39 , 41 , 45 , 46 ]. In patients who received postoperative adjuvant chemotherapy, tumor recurrence was prevented in five out of seven patients.…”

Carcinomas with a Squamous Cell Lineage

“…Adenosquamous carcinoma of the liver has been observed in combination with hepatocellular carcinoma (Zhang et al 2001;Tsuneyama et al 2003). Also synchronous hepatic ASC and hepatocellular carcinoma have been described (Shimizu et al 2013). In a middle-aged female patient with recurrent fever and a clinical diagnosis of hepatic abscess, adenosquamous carcinoma was found to have arisen in biliary cystadenocarcinoma (Moore et al 1984).…”

A case study of a collision tumor composed of cancers of the bile duct and pancreas

“…The number of reports of dual cancers is increasing every year due to the marked progress of diagnostic imaging technology in recent years, increasing frequency of medical checkups, and the aging of the population [ 4 - 6 ]. The reported rate of pancreatic cancer associated with other organ malignancies is 5.6% to 16.6% [ 7 , 8 ].…”