Synchronous diffuse large B cell lymphomas of the endometrium and breast: a staging dilemma

Gleeson, Jack Patrick; Woods, Graham; Watson, Geoffrey Alan; Ryan, James W.; Doyle, E.; Quinn, Fiona; O’Keane, J. C.; McCaffrey, John

doi:10.1007/s11845-017-1599-7

Cited by 2 publications

(2 citation statements)

References 21 publications

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“…Primary breast lymphoma also occurs in females commonly, but the prognosis of PLFGT is better than primary breast lymphoma [13]. Researchers suspect that hormonal stimulation could potentially in uence the growth of PLFGT lesions as primary breast lymphoma [14]. But this has not been con rmed at present.…”

Section: Discussionmentioning

confidence: 99%

Epidemiological Features for Primary Lymphoma of the Female Genital Tract Patients and Development of a Nomogram to Predict Survival

Peng

et al. 2021

Preprint

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Background: Primary lymphoma of the female genital tract (PLFGT) is a sporadic extranodal lymphoma. Its epidemiology and prognosis are not fully recognised. Our study aimed to construct and validate prognostic nomograms for predicting survival for patients with PLFGT.Methods: Incidence rate from 1975 to 2017 and patients with PLFGT from 1975 to 2011 in the Surveillance, Epidemiology and End Results (SEER) database were retrospectively reviewed. The nomograms of OS and DSS were established according to the multivariate Cox regression analyses. The concordance index (C-index) and calibration plots were used to demonstrate its robustness and accuracy.Results: A total of 617 PLFGT patients were identified. The overall incidence of PLFGT is 0.44/1,000,000 (adjusted to the US standard population in 2000) from 1975 to 2017. Age, histological subtype, Ann Arbor Stage, and therapeutic strategy were identified as independent prognostic factors for overall survival (OS) and disease-specific survival (DSS) by multivariate Cox regression (P < 0.05). Nomograms to predict 1-, 5-, and 10- year OS and DSS were established. The C-index and calibration plots showed a good discriminative ability and an optimal accuracy of the nomograms. Patients were devided into three risk groups according to the model of OS.Conclusions: The nomograms were developed and validated as an individualized tool to predict OS and DSS.

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Section: Discussionmentioning

confidence: 99%

Epidemiological Features for Primary Lymphoma of the Female Genital Tract Patients and Development of a Nomogram to Predict Survival

Peng

et al. 2021

Preprint

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show abstract

“…Primary breast lymphoma also occurs in females commonly, but the prognosis of PLFGT is better than primary breast lymphoma [ 13 ]. Researchers suspect that hormonal stimulation could potentially influence the growth of PLFGT lesions as primary breast lymphoma [ 14 ]. But this has not been confirmed at present.…”

Section: Discussionmentioning

confidence: 99%

Epidemiological features for primary lymphoma of the female genital tract patients and development of a nomogram to predict survival

Peng

et al. 2022

Annals of Medicine

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Background Primary lymphoma of the female genital tract (PLFGT) is a sporadic extranodal lymphoma. Its epidemiology and prognosis are not fully recognized. Our study aimed to construct and validate prognostic nomograms for predicting survival for patients with PLFGT. Methods Incidence rate from 1975 to 2017 and patients with PLFGT from 1975 to 2011 in the Surveillance, Epidemiology and End Results (SEER) database were retrospectively reviewed. The nomograms of overall survival (OS) and disease-specific survival (DSS) were established according to the multivariate Cox regression analyses. The concordance index (C-index) and calibration plots were used to demonstrate its robustness and accuracy. Results A total of 617 PLFGT patients were identified. The overall incidence of PLFGT is 0.437/1,000,000 (adjusted to the US standard population in 2000) from 1975 to 2017. Age, histological subtype, Ann Arbor Stage, and therapeutic strategy were identified as independent prognostic factors for OS and DSS by multivariate Cox regression ( p < .05). Nomograms to predict 1-, 5-, and 10-year OS and DSS were established. The C-index and calibration plots showed a good discriminative ability and an optimal accuracy of the nomograms. Patients were divided into three risk groups according to the model of OS. Conclusions The incidence of PLFGT has increased in the past 40 years, and the nomograms were developed and validated as an individualized tool to predict OS and DSS for all PLFGT patients and DLBCL patients. All patients are divided into three risk groups to assist clinicians to identify patients at high-risk and choose the optimal individualized treatments for patients. Highlights The incident of PLFGT and its subtypes were calculated and compared. Nomograms were constructed to predict the 1-, 5-, and 10-year OS and DSS. Patients are divided into the low-risk, medium-risk, and high-risk according total score of the nomogram.

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Synchronous diffuse large B cell lymphomas of the endometrium and breast: a staging dilemma

Abstract: Staging of synchronous extra-nodal lymphomas, particularly when they arise in rare sites such as the endometrium and breast, is difficult and previously unreported. We present our rationale for defining our patient's disease as synchronous stage IE DLBCL's.

Cited by 2 publications

References 21 publications

Epidemiological Features for Primary Lymphoma of the Female Genital Tract Patients and Development of a Nomogram to Predict Survival

Epidemiological Features for Primary Lymphoma of the Female Genital Tract Patients and Development of a Nomogram to Predict Survival

Epidemiological features for primary lymphoma of the female genital tract patients and development of a nomogram to predict survival

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