Synchronous colorectal adenocarcinoma and gastrointestinal stromal tumor in Meckel's diverticulum; an unusual association

Kosmidis, Christoforos; Efthimiadis, Christoforos; Levva, Sofia; Anthimidis, Georgios; Baka, Sofia; Grigoriou, Marios; Tzeveleki, I.; Masmanidou, Maria; Zaramboukas, Thomas; Basdanis, G.

doi:10.1186/1477-7819-7-33

Cited by 18 publications

(7 citation statements)

References 19 publications

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“…Benign (leiomyomas, angiomas, lipomas) and malignant (adenocarcinoma, sarcoma, carcinoid tumour and (Gastrointestinal stromal tumor) neoplasms are known [4,6,7]. No malignant histology was identified in our patient.…”

Section: Discussionmentioning

confidence: 68%

Meckel’s diverticulum with benign stricture: A very rare cause of intestinal obstruction

et al. 2010

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Section: Discussionmentioning

confidence: 68%

Meckel’s diverticulum with benign stricture: A very rare cause of intestinal obstruction

et al. 2010

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“…A review of case reports in the literature showed that stromal tumours of the small intestine are mostly small and are associated with low to intermediate risk when classified according to Fletcher's risk classification [17]. (Tables 1 and 2) [4,10,12,13,[18][19][20][21][22][23]. The presented case also had a small ileum-originated low-risk GIST.…”

Section: Discussionmentioning

confidence: 99%

Small intestine-derived gastrointestinal stromal tumour diagnosed synchronously with colon adenocarcinoma: a and review of the literature

Tanrıverdi¹,

Meydan²,

Barutça³

et al. 2011

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Gastrointestinal stromal tumours (GISTs) account for 0.1-3% of all gastrointestinal cancers. Although nausea, emesis, abdominal pain, GIS haemorrhage, and non-specific symptoms associated with metastatic disease are common, asymptomatic cases are not rare. They are located in the stomach in approximately 60-70% of cases, and in the small intestine in 20-30% of cases. Gastrointestinal stromal tumours can be seen synchronously or metachronously with other epithelial cancers. The co-occurrence of colon adenocarcinomas and GISTs in the small intestine is not common. The genetic pathways in the tumourigenesis of two different neoplasms (GIST and colorectal adenocarcinoma) being different was suggested as a probable cause; however; although the number of cases is limited, some researchers have reported that they could not rule out the possibility that this association is not coincidental. Herein we present a patient who was concomitantly diagnosed with a GIST as a result of an ileal lesion biopsy performed during surgery for colon adenocarcinoma.

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“…12 The role of this thorough search has clearly not been made obsolete by the tremendous advances in preoperative imaging modalities and hence its importance cannot be understated. The impact of synchronously existing tumours on the overall prognosis of a patient must be considered when planning therapy in such instances as well.…”

Section: Discussionmentioning

confidence: 99%

Coexistence of colonic carcinoma, renal cell carcinoma and gastrointestinal stromal tumour—A case report

Burgess

O’Shea

Gaskin

et al. 2010

International Journal of Surgery Case Reports

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The occurrence of synchronous primary neoplasms remains an issue of great interest to surgeons and oncologists in particular, and the medical field in general. The question of common genetic pathways in the pathogenesis of such neoplasms is always raised when such associations are seen-whether metachronously or synchronously. The possibility of the coexistence of multiple tumours in the same patient must be taken into consideration when preparing patients for operation and a thorough search of the intraperitoneal organs for such coexistence remains important.A case of synchronously resected caecal carcinoma, jejunal gastrointestinal stromal tumour and renal cell carcinoma is presented here, along with a literature review on synchronous tumour resection.

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Synchronous colorectal adenocarcinoma and gastrointestinal stromal tumor in Meckel's diverticulum; an unusual association

Cited by 18 publications

References 19 publications

Meckel’s diverticulum with benign stricture: A very rare cause of intestinal obstruction

Meckel’s diverticulum with benign stricture: A very rare cause of intestinal obstruction

Small intestine-derived gastrointestinal stromal tumour diagnosed synchronously with colon adenocarcinoma: a and review of the literature

Coexistence of colonic carcinoma, renal cell carcinoma and gastrointestinal stromal tumour—A case report

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