Synchronous Calcifying Epithelial Odontogenic Tumor: Case Report and Analysis of the 5 Cases in the Literature

Abstract

Calcifying epithelial odontogenic tumor (CEOT), or Pindborg tumor, is infrequent and accounts for less than 1% of all odontogenic tumors. It is benign and usually asymptomatic but displays locally infiltrative and expansile behavior. Synchronous lesions affecting the jaws are exceedingly rare. We present a case of synchronous CEOTs affecting the maxilla and mandible and describe the clinical, radiographic, histologic, and immunohistochemical features. We further review five cases previously described in the literature.

Pindborg tumor associated with a supernumerary tooth: a case report

“…In approximately 50% of cases, CEOT is associated with an unerupted tooth. 14,16 However, association with a supernumerary tooth as in the present case is rarely observed (Table 1). 12,17 T he c li ni c al c ha ra c te ri s ti cs o f CE OT a re nonspecific.…”

“…There is no sex predilection for CEOT, and the tumor usually causes a painless, slow-growing swelling. 9,10,13,14 However, tumors in the maxilla tend to grow rapidly and are not circumscribed. 15 In the present case, the tumor exhibited a slow evolution and no symptoms; however, the exacerbation of growth in the last 8 months resulted in ulcerations and paresthesia.…”

An Aggressive Calcifying Epithelial Odontogenic Tumor: A Rare Case Report

“…PTCH1 mutation first detected in nevoid basal cell carcinoma syndrome [9]and has also been found in both CEOT and keratocystic odontogenic tumors [10]. However, the clinical significance of these mutations is unknown [10].CEOT affected a wide range of ages, most commonly occurs between 20 and 60 years of age, with a peak incidence in the 5th decade [10] and equal distribution between both gender [5]. However, some cases reported before 20 years of age [4,10], present case also reported CEOT affected an 18-year-old female.…”

“…However, some cases reported before 20 years of age [4,10], present case also reported CEOT affected an 18-year-old female. It commonly presented as asymptomatic, slow-growing, and locally aggressive lesion [5]. Initial clinical signs/symptoms of the lesion are a local expansion of bone with the migration of the teeth of the affected region.…”

“…It manifests clinically as asymptomatic, slowgrowing, and locally aggressive lesion which causes expansion of the affected bone. The posterior mandible is the most common site for its occurrence and approximately 50% of cases are associated with erupted or unerupted tooth [5]. It is commonly seen in the 4th to 6th decade of life with no gender predilection [6].…”