Synchronous breast cancer and lymphoma: a case series and a review of the literature

Cuff, Katharine; Dettrick, Andrew; Chern, Boris

doi:10.1136/jcp.2009.069625

Cited by 25 publications

(30 citation statements)

References 9 publications

(3 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Synchronous or metachronous presentations of BC and FL are rare, and to the best of our knowledge, only six cases have previously been reported in the literature (10–14); the present study is the seventh case. Profiles of the seven cases are summarized in Table I.…”

Section: Discussionmentioning

confidence: 68%

A rare case of non-invasive ductal carcinoma of the breast coexisting with follicular lymphoma: A case report with a review of the literature

et al. 2014

View full text Add to dashboard Cite

The double presentation of breast cancer and follicular lymphoma is extremely rare, and only six cases have previously been reported in the literature. In the present study, a case of synchronous ductal carcinoma in situ (DCIS) of the breast and follicular lymphoma is reported. During an annual breast screening procedure, a 49-year-old female presented with a hard induration under the nipple of the right breast and swelling of a soft lymph node (LN) in the right axilla. Mammography and ultrasonography revealed two lesions in the right breast: One was a tumor with microcalcification, 1.0 cm in diameter, and the other was a large, crude calcification, 2.5 cm in diameter. In addition, computed tomography and positron emission tomography revealed swellings of the bilateral axillary (Ax) LN and intra-abdominal para-aortic LN. The patient underwent excisions of the large calcified mass, a micro-calcified tumor and the right AxLN. The pathological and immunohistochemical studies revealed fat necrosis and DCIS of the breast, which was positive for the estrogen receptor and the progesterone receptor, while human epidermal growth factor receptor II protein expression was evaluated as 2+ and stage was classified as pTis pN0 M0, stage 0. Furthermore, the Ax node was diagnosed as follicular lymphoma, which was positive for cluster of differentiation (CD)20, CD79a, CD10 and B-cell lymphoma (Bcl)-2 protein, but negative for Bcl-6 protein. The clinical stage was classified as stage III. The patient was administered chemotherapy followed by radiotherapy to the conserved breast. Two years have passed since the surgery, and the patient is disease-free.

show abstract

Section: Discussionmentioning

confidence: 68%

A rare case of non-invasive ductal carcinoma of the breast coexisting with follicular lymphoma: A case report with a review of the literature

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Patients with lymphoma are known to be chronically immunosuppressed, which may predispose to the development of a second malignancy [10]. It has also been suggested that the antigenic stimulation from an as yet undefined breast carcinoma antigen may drive the development of a mucosa-associated lymphoid tissue (MALT) lymphoma, analogous to the effect of chronic Helicobacter pylori infection on the pathogenesis of gastric MALT lymphomas [11].…”

Section: Discussionmentioning

confidence: 99%

Synchronous invasive ductal carcinoma and intravascular large B-cell lymphoma of the breast: a case report and review of the literature

Mantoo

Lim

et al. 2014

World J Surg Onc

View full text Add to dashboard Cite

Primary breast lymphomas (PBLs) represent less than 1% of all breast malignancies. Intravascular large B-cell lymphoma (ILBCL) is a rare, aggressive form of extranodal lymphoma. Breast involvement has only been described in the literature once previously. ILBCL is characterized by the proliferation of tumour cells within the lumen of small vessels of involved organs, resulting in their eventual occlusion. Clinical features are often vague, diagnosis is difficult and delayed, and prognosis is usually poor. We report the first ever case of synchronous ILBCL and invasive ductal carcinoma (IDC) of the breast in a patient presenting with pyrexia of unknown origin and altered mental status who underwent modified radical mastectomy and subsequent chemotherapy, and review the literature regarding intravascular large B-cell lymphoma, PBLs and synchronous carcinomas and lymphomas of the breast.

show abstract

“…The occurrence of second primary neoplasms in patients with history of malignant tumors has been well documented [2]; however, the synchronous presentation of 2 malignancies is an extremely rare event that involves approximately 0.8% of these patients [3]. …”

Section: Discussionmentioning

confidence: 99%

Lymphatic mapping could not be impaired in the presence of breast carcinoma and coexisting small lymphocytic lymphoma

Arana

Vasquez-Del-Aguila

Espinosa³

et al. 2013

Am J Case Rep

View full text Add to dashboard Cite

Patient: Female, 66Final Diagnosis: Infiltrating ductal carcinoma • small lymphocytic lymphomaSymptoms: —Medication: —Clinical Procedure: Sentinel Lymph Node Biopsy • lumpectomy • axillary lymph node dissectionSpecialty: Breast cancer surgeryObjective:Rare presentation of two concomitant malinganciesBackground:Lymphatic mapping of axillary breast cancer metastases in the presence of concomitant lymphoproliferative disease is still a controversial topic. Previous reports have postulated that tumor collision in the lymph nodes could lead to false-negative results of sentinel lymph node biopsy, leading to erroneous staging.Case Report:We present the case of a 66-year-old woman with infiltrating ductal breast carcinoma and small lymphocytic lymphoma in whom we performed a lumpectomy and sentinel lymph node biopsy with Technetium-99 and 1% methylene blue, followed by axillary lymph node dissection regardless of the intraoperative status, which was negative. Final pathology confirmed the absence of lymph node metastases.Conclusions:Previously published cases reported correct assessment of SLNB in patients with concomitant small lymphocytic lymphoma and breast carcinoma. We postulate a possible pathological explanation for this: lymphoid cell clusters with pseudofollicles or proliferative centers of small lymphocytic lymphoma are localized outside the nodal sinuses of the lymph node, maintaining its capability of draining, and thus, the feasibility of SLNB in these patients, as in the presented case.

show abstract

Synchronous breast cancer and lymphoma: a case series and a review of the literature

Cited by 25 publications

References 9 publications

A rare case of non-invasive ductal carcinoma of the breast coexisting with follicular lymphoma: A case report with a review of the literature

A rare case of non-invasive ductal carcinoma of the breast coexisting with follicular lymphoma: A case report with a review of the literature

Synchronous invasive ductal carcinoma and intravascular large B-cell lymphoma of the breast: a case report and review of the literature

Lymphatic mapping could not be impaired in the presence of breast carcinoma and coexisting small lymphocytic lymphoma

Contact Info

Product

Resources

About