Synchronous bilateral Paget’s disease of the breast: A case report

Abstract

Abstract. Synchronous bilateral Paget's disease of the nipple is extremely rare. In the present study, we report a case of synchronous bilateral Paget's disease in a 45-year-old woman who had a medical history of gastric cancer. The patient presented with a 6-month history of eczema and itching in both nipples. Mammography and ultrasonography did not reveal any mass lesions in the bilateral breast, and computed tomography and bone scintigraphy showed no site of distant metastasis. The patient was scheduled for mastectomy and sentinel node biopsy. The histological diagnosis was Paget's disease of the breast with no evidence of underlying invasive ductal carcinoma or ductal carcinoma in situ of the breast tissue. There was no metastasis in either of the sentinel nodes. Immunohistochemical staining showed a negative expression of oestrogen and progesterone receptors. The patient has not received chemotherapy, radiotherapy or hormonal therapy. The patient has been disease-free for 7 months following surgery.

Bilateral Paget’s Disease of the Breast—Case Report of Long-Time Misdiagnosed Tumors with Underlying Ductal Carcinomas and Review of the Literature

“…For bilateral PD the limited data are controversial. Sahoo et al [ 4 ] connected the PD of its patient to an underlying lobular CIS because of the immunohistochemical profile; Xie et al [ 10 ] found no underlying tumor, whereas the patients of Anderson [ 11 ] and Franceschini et al [ 12 ] as well as our patient had underlying ductal carcinomas.…”

Calciphylaxis and Ulcerative Lesions of Bilateral Nipple–Areolar Complex Due to Alcoholic Liver Disease

“…There are extremely few reports of bilateral synchronous Paget's disease without underlying breast cancer in literature. 2 13 …”

“… 1 Bilateral eczematous lesions of NAC are more often due to benign etiology with Paget's disease reported extremely rarely. 2 We discuss an extremely rare case with calciphylaxis due to underlying liver disease and sole breast involvement as benign NAC ulceration. Few cases of breast parenchymal involvement by calciphylaxis in end-stage renal disease patients have been reported; however, to the best of our knowledge, there are no cases due to underlying liver disease.…”

Paget's disease of the breast in male with underlying invasive ductal carcinoma: A case report with review of literature

“…There are many conditions that may mimic PD of the breast such as psoriasis, contact dermatitis, erosive adenomatosis of the nipple, intraductal papilloma, nipple adenoma, basal cell carcinoma, Bowen's disease, malignant melanoma, and Toker cell hyperplasia [ 23 ]. It is commonly mistaken with benign dermatological diseases of the nipple, particularly, dermatitis [ 24 ]. PD of the breast can be distinguished from a locally advanced breast cancer presenting as satellite skin nodules [ 10 ].…”