Synchronous bilateral breast cancer patients submitted to conservative treatment and brachytherapy – The experience of a service

Pinheiro, Joana; Rodrigues, Darlene; Fernandes, Pedro; Pereira, Alexandre da Costa; Trigo, L.

doi:10.1016/j.rpor.2018.06.004

Cited by 2 publications

(2 citation statements)

References 57 publications

(76 reference statements)

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“…Despite the low frequency of SBBC (0.2%-3% of all breast cancers), the incidence of SBBC has been rising due to improved diagnostic approaches [3,4]. The key risk factors of SBBC include younger age at presentation [5], a family history of bilateral breast cancer [6], lobular histology [7], multicentricity [8], existence of sclerotic disease [4] and BRCA mutations [9]. Furthermore, an estrogen receptor (ER)-positive and human epidermal growth factor receptor 2 (HER2)negative status was reported in the majority of SBBC tumors [10].…”

Section: Introductionmentioning

confidence: 99%

Expression of Senescence and Apoptosis Biomarkers in Synchronous Bilateral Breast Cancer: A Case Report

et al. 2021

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Background: Synchronous bilateral breast cancer (SBBC) provides a special condition where two independent breast tumors are exposed to cancer pharmacotherapy within a uniform pharmacokinetic milieu. Both senescence and apoptosis are established responses to therapy; however, they have potentially variable contributions to the overall outcome of treatment, which are yet to be determined. Methods: In this report, we describe the clinicopathological picture of two SBBC cases that received standard anticancer treatment and assess their expression profile of several molecular hallmarks of senescence and apoptosis. Results: Our analysis identified that synchronous tumors have variable expression profiles of both senescence- and apoptosis-associated biomarkers, despite comparable pathological responses to neoadjuvant chemotherapy and current survival rates. Conclusions: Our results highlight the variable expression of senescence- and apoptosis-associated markers in breast tumors (despite the shared somatic genetic background) and invites a large-scale assessment of both senescence and apoptosis in breast cancer tissue in vivo and their contribution to the pathological response and overall survival.

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Section: Introductionmentioning

confidence: 99%

Expression of Senescence and Apoptosis Biomarkers in Synchronous Bilateral Breast Cancer: A Case Report

et al. 2021

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“…The occurrence of bilateral breast cancer (BBC) is increasing nowadays with a reported incidence ranging between 1.4% and 12% 1,2 . However, in recent literature, patients with BBC showed a significantly worse distant relapse‐free survival (RFS) as compared to those with unilateral breast cancer (UBC), as distant metastases were frequently reported in patients with BBC 2,3 . Early detection and treatment of BBC is important to improve the overall prognosis of patients with breast cancer.…”

Section: Introductionmentioning

confidence: 99%

The hidden breast lesions: A case report of bilateral breast cancer

Dai

Bao

Tan

et al. 2021

J of Clinical Ultrasound

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Bilateral breast cancer (BBC) is rare and is associated with an unfavorable prognosis. Consequently it is crucial to improve diagnostic performance of breast cancer in the clinical setting. We report a case of BBC in a 66‐year‐old woman and describe the imaging findings, including mammography, hand‐held ultrasound, automated breast ultrasound, anatomical intelligence for breast ultrasound (AI‐breast), and magnetic resonance imaging. Only AI‐breast ultrasound successfully located the two tumors, while other imaging examinations failed to detect the tumor in the right breast.

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Synchronous bilateral breast cancer patients submitted to conservative treatment and brachytherapy – The experience of a service

Abstract: BBC represents a complex challenge for doctors, because in some cases there is a tendency to use more aggressive treatments and, at the same time, it is not easy to achieve the timing for the correct treatment.

Cited by 2 publications

References 57 publications

Expression of Senescence and Apoptosis Biomarkers in Synchronous Bilateral Breast Cancer: A Case Report

Expression of Senescence and Apoptosis Biomarkers in Synchronous Bilateral Breast Cancer: A Case Report

The hidden breast lesions: A case report of bilateral breast cancer

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