Synchronization phenomena in human epileptic brain networks

Lehnertz, Klaus; Bialonski, Stephan; Horstmann, Marie-Therese; Krug, Dieter; Rothkegel, Alexander; Staniek, Matthäus; Wagner, Tobias

doi:10.1016/j.jneumeth.2009.05.015

Cited by 226 publications

(164 citation statements)

References 152 publications

(163 reference statements)

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“…Instead, the great variability of the LORETA1 and LSC1 findings indicate great variability of the individual network abnormalities. The diversity of our findings is in accord with a lot of papers reporting poor topographical correspondence between localized pathology or epileptic dysfunction and diffusely distributed, abnormal, resting-state network dynamics (Bartolomei et al, 2006;Bettus et al, 2008;Alstott et al, 2009;Lehnertz et al, 2009). Another source of the dissimilar findings might be the dissimilar topographical distribution of the underlying pathological process.…”

Section: Quantitative Eeg Abnormalities In the Active State Of The DIsupporting

confidence: 86%

“…The network theory was originally based on neurophysiological argumentation (Spencer, 2002). However, the idea that focal cerebral manifestations and/ or epilepsy are associated with topographically distributed abnormal network dynamics has been supported by graph analysis of EEG, magnetoencephalographic and functional MRI data and simulation studies as well (Bartolomei et al, 2006;Bettus et al, 2008;Alstott et al, 2009;Lehnertz et al, 2009). Also treatment-related changes of magnetoencephalographic functional connectivity were reported (Douw et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Remission of benign epilepsy with rolandic spikes: An EEG-based connectivity study at the onset of the disease and at remission

Clemens¹,

Puskás²,

Besenyei³

et al. 2013

Epilepsy Research

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Section: Quantitative Eeg Abnormalities In the Active State Of The DIsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Remission of benign epilepsy with rolandic spikes: An EEG-based connectivity study at the onset of the disease and at remission

Clemens¹,

Puskás²,

Besenyei³

et al. 2013

Epilepsy Research

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show abstract

“…There exists many excellent books and reviews of time series and synchronization methods, just to mention few (Pereda et al 2005;Lehnertz et al, 2009). …”

Section: Synchronization Measuresmentioning

confidence: 99%

Hyper-Synchronization, De-Synchronization, Synchronization and Seizures

Pastor¹,

Sola²,

Ortega³

2012

Epilepsy - Histological, Electroencephalographic and Psychological Aspects

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“…4 Đnsan beyni alt sistemlerin karşılıklı olarak etkileştiği karmaşık bir ağdır ve senkronizasyonun beyin fonksiyonunda ve disfonksiyonunda önemli bir rol oynadığı yaygın bir şekilde kabul edilmektedir. 5 Farklı beyin yapılarında veya yapıları arasında meydana gelen senkronizasyon veya osilatör aktivite anormalliklerinin; epilepsi, parkinson, şizofre-ni gibi birkaç nörolojik hastalıklar ile ilişkisi olabileceği bildirilmiştir. 6,7 Đlk olarak 1960'larda uluslararası epilepsi uzmanlarının bir araya gelmeleriyle epileptik nöbet-lerin sınıflandırılmasının temelleri atılmıştır.…”

Section: Uluslararasıunclassified

Models of experimental epilepsy

Bambal

Cakil²,

Ekici³

2011

J Clin Exp Invest

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ÖZETEpilepsi, % 1 prevelansa sahip olduğu tahmin edilen, dünyada en yaygın görülen ciddi nörololojik durumdur. Birçok sayıda, deneysel epilepsi ve nöbet modeli gelişti-rilmiştir. Bu deneysel modeller hayvanlarda elektrik uyarımı, kimyasal konvülsanlar, genetik modeller, yapısal lezyonlar, fiziksel uyaranlar (soğuk, basınç, hipertermi, elektriksel) ile oluşturulmaktadır. Đyi karakterize edilmiş hayvan modelleri epileptogenezisin (normal nöronal bir ağın spontan, tekrarlayan nöbetlerin oluştuğu bir hipereksitabilite ağına değişmesi) altında yatan temel mekanizmaların anlaşılmasına olanak sağlayabilmektedir. Üstelik bu modeller epilepsi tedavisinde yeni tedavi edici yaklaşımların belirlenmesinde de yararlı olabilmektedir. Klin Den Ar Derg 2011; 2(1): 118-123Anahtar kelimeler: Epilepsi, nöbet, deneysel modeller ABSTRACT Epilepsy is the most common serious neurological condition in the world, with an estimated prevalence of 1% of the population. A large number of experimental models of seizure and epilepsy have been developed. These experimental models are elicited by chemical convulsants, electrical stimulation, genetic models, structural lesions, physical stimuli (cold, pressure, hyperthermia, electrical) in animals. Well-characterized animal models may allow the understanding of the basic mechanisms underlying epileptogenesis (it refers to the alteration of a normal neuronal network into a hyperexcitable network in which recurrent, spontaneous seizures occur). Moreover, these models might also prove useful in identifying novel therapeutic approaches to treatment of epilepsy. J Clin Exp Invest 2011; 2(1): 118-123

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Synchronization phenomena in human epileptic brain networks

Cited by 226 publications

References 152 publications

Remission of benign epilepsy with rolandic spikes: An EEG-based connectivity study at the onset of the disease and at remission

Remission of benign epilepsy with rolandic spikes: An EEG-based connectivity study at the onset of the disease and at remission

Hyper-Synchronization, De-Synchronization, Synchronization and Seizures

Models of experimental epilepsy

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