Synchronization of cardiac autonomic neural discharge with epileptogenic activity: the lockstep phenomenon

Lathers, Claire M.; Schraeder, Paul L.; Weiner, Francine L.

doi:10.1016/0013-4694(87)90023-x

Cited by 147 publications

(60 citation statements)

References 39 publications

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“…19,20 In pentylenetetrazol treated epileptic cats, Lathers et al demonstrated a "one-to-one" transmission of cerebral epiletogenic discharges onto the heart. 23 Such bursts of activity might account for myocardial infractions as observed in the NOMAS study and described in many previous publications. 24 Sympathetic overstimulation of the heart may cause increases in troponin I, diffuse myofibrillary necrosis, perivascular and interstitial fibrosis as well as myocyte vacuolization in the absence of ischemic heart disease.…”

mentioning

confidence: 52%

Stroke-Induced Sudden-Autonomic Death

Hilz

Schwab

2008

Stroke

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mentioning

confidence: 52%

Stroke-Induced Sudden-Autonomic Death

Hilz

Schwab

2008

Stroke

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“…Animal experiments reveal that interictal epileptogenic discharges, frequently seen in refractory TLE patients, enhance cardiovascular sympathetic tone [41]. In pentylenetetrazole-treated cats, Lathers et al observed intermittent 1:1 synchronization of interictal spikes with cardiac sympathetic discharges (''lockstep phenomenon'') [41]. The clinical significance of increased sympathetic tone on the cardiovascular system has been demonstrated in patients with myocardial infarction.…”

Section: Discussionmentioning

confidence: 97%

“…However, further analysis of cardiovascular autonomic data in the present study showed a marked increase of relative low-frequency power (LF-power in relation to the sum of LF-and HF-power) and of the LF/HF ratio despite the reduction of the absolute heart rate variability in TLE patients. Animal experiments reveal that interictal epileptogenic discharges, frequently seen in refractory TLE patients, enhance cardiovascular sympathetic tone [41]. In pentylenetetrazole-treated cats, Lathers et al observed intermittent 1:1 synchronization of interictal spikes with cardiac sympathetic discharges (''lockstep phenomenon'') [41].…”

Section: Discussionmentioning

confidence: 98%

Impaired baroreflex function in temporal lobe epilepsy

2006

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Changes of cardiovascular function are frequent in temporal lobe epilepsy (TLE). The baroreflex - the most important reflex for cardiovascular stability - has not been studied systematically in TLE. We evaluated cardiovascular variability and baroreflex function in TLE. In 22 TLE patients and 20 controls, we continuously monitored heart rate (HR) and blood pressure (BP). Time-domain parameters were derived from recordings at rest and from standard cardiovascular reflex tests. Spectral analysis determined sympathetic and parasympathetic modulation of HR and BP in the low (LF-power) and high frequency range (HF-power). We calculated the relative LF- and HF-powers of HR in relation to the sum of LF- and HF-powers. LF/HF-ratio of HR was assessed as a parameter of sympatheticovagal balance. LF-transfer function gain between BP and HR determined baroreflex function.Time-domain parameters did not differ between TLE patients and controls. Spectral analysis showed decreased absolute LF- and HF-powers but increased relative LF-power and LF/HF-ratio of HR in TLE. LF-transfer function gain between BP and HR was reduced in TLE (p<0.05). The reduction of absolute LF- and HF-powers indicates decreased total autonomic variability in TLE. However, increased relative LF-power and LF/HF-ratio of HR in TLE show a relative increase of sympathetic tone. Most importantly, we demonstrate an impaired baroreflex function in TLE. These cardiovascular autonomic abnormalities may contribute to cardiac arrhythmia in TLE.

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“…With regard to synchrony and central processing, previous work has indicated that synchronous (bursty) sympathetic activity may be related to, for example, cardiac and respiratory rhythms (Adrian et al, 1932), intermittent isometric exercise (Victor et al, 1995), and in pathological conditions, epileptiform discharges (Lathers et al, 1987). Such synchrony may be purely caused by imposition of other oscillating activities on the sympathetic nervous system, "irradiation" (Koepchen et al, 1981).…”

Section: Functional Significance Of Synchronization Of Sympathetic Acmentioning

confidence: 99%

Sympathetic Neuronal Oscillators are Capable of Dynamic Synchronization

et al. 1999

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In this paper we show that the discharges of sympathetic neurons innervating an identified peripheral target are driven by multiple oscillators that undergo dynamic synchronization when an entraining force, central respiratory drive (CRD), is increased. Activity was recorded from postganglionic sympathetic neurons (PGNs) innervating the caudal ventral artery of the rat tail: (1) at the population level from the ventral collector nerve (VCN); and (2) from pairs of single PGNs recorded simultaneously using a focal recording technique. Autospectral analysis of VCN activity revealed a more prominent rhythmical component in the presence of CRD than in its absence, suggesting that (1) multiple oscillators drive the discharges of PGNs and (2) these oscillators can be entrained and therefore synchronized by CRD. This interpretation was supported by analysis of the firing behavior of PGN pairs. Autocorrelation and cross-correlation analysis showed that pairs were not synchronized in the absence of CRD but showed significant synchronization when CRD was enhanced. Time-evolving spectral analysis and raster plots demonstrated that the temporal stability of PGN-to-PGN and CRD-to-PGN interactions at a given level of CRD were also dynamic in nature, with stable constant phase relationships predominating as CRD was increased. This is the first reported example of dynamic synchronization in populations of single postganglionic sympathetic neurons, and we suggest that, as in sensory processing and motor control, temporal pattern coding may also be an important feature of neuronal discharges in sympathetic pathways.

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Synchronization of cardiac autonomic neural discharge with epileptogenic activity: the lockstep phenomenon

Cited by 147 publications

References 39 publications

Stroke-Induced Sudden-Autonomic Death

Stroke-Induced Sudden-Autonomic Death

Impaired baroreflex function in temporal lobe epilepsy

Sympathetic Neuronal Oscillators are Capable of Dynamic Synchronization

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