Abstract:Background: We examined the efficiency and safety of a specific synbiotic compound, brand name Kidilact®, in the treatment of asthma in children 12 years of age or younger. Materials and Methods: This double-blinded, randomized, placebo-controlled clinical trial was conducted in Tehran, Iran, from May 22, 2016, to May 21, 2017. One hundred children, 12 years of age or younger, who suffered from mild to moderate asthma were recruited in this study. The subjects were randomly divided into two groups; the experim… Show more
“…zinc and fructo-oligosaccharide) asthma management. Multiple outcomes did not show a difference between both groups; the number of outpatient visits, 19 in the synbiotic versus 55 in the control arm ( p = 0.001), was the only statistically significant difference [ 69 ].…”
Allergic diseases including allergic rhinitis and asthma are increasing in the developing world, related to a westernizing lifestyle, while the prevalence is stable and decreasing in the industrialized world. This paper aims to answer the question if prevention and/or treatment of allergic rhinitis and asthma can be achieved by administrating pro-, pre- and/or synbiotics that might contribute to stabilizing the disturbed microbiome that influences the immune system through the gut–lung axis. We searched for relevant English articles in PubMed and Google Scholar. Articles interesting for the topic were selected using subject heading and key words. Interesting references in included articles were also considered. While there is substantial evidence from animal studies in well controlled conditions that selected probiotic strains may offer benefits in the prevention of wheezing and asthma, outcomes from clinical studies in infants (including as well pre- and postnatal administration) are disappointing. The latter may be related to the multiple confounding factors such as environment, strain selection and dosage, moment of administration and genetic background. There is little evidence to recommend administration of pro, pre- or synbiotics in the prevention of asthma and allergic rhinitis in children.
“…zinc and fructo-oligosaccharide) asthma management. Multiple outcomes did not show a difference between both groups; the number of outpatient visits, 19 in the synbiotic versus 55 in the control arm ( p = 0.001), was the only statistically significant difference [ 69 ].…”
Allergic diseases including allergic rhinitis and asthma are increasing in the developing world, related to a westernizing lifestyle, while the prevalence is stable and decreasing in the industrialized world. This paper aims to answer the question if prevention and/or treatment of allergic rhinitis and asthma can be achieved by administrating pro-, pre- and/or synbiotics that might contribute to stabilizing the disturbed microbiome that influences the immune system through the gut–lung axis. We searched for relevant English articles in PubMed and Google Scholar. Articles interesting for the topic were selected using subject heading and key words. Interesting references in included articles were also considered. While there is substantial evidence from animal studies in well controlled conditions that selected probiotic strains may offer benefits in the prevention of wheezing and asthma, outcomes from clinical studies in infants (including as well pre- and postnatal administration) are disappointing. The latter may be related to the multiple confounding factors such as environment, strain selection and dosage, moment of administration and genetic background. There is little evidence to recommend administration of pro, pre- or synbiotics in the prevention of asthma and allergic rhinitis in children.
“…A further Iranian RCT investigated the effects of a synbiotic compound containing Bifidobacterium infantis and fructooligosaccharide in school children (12 years of age or younger) with mild to moderate asthma [ 49 ]. The treatment lasted six months.…”
Section: Probiotic Supplementation In Children With Asthma or Wheezin...mentioning
confidence: 99%
“…Another important aspect requires adequate attention: there is evidence that most probiotics fail the primary prevention of asthma [ 78 , 79 ]. Contrariwise, some convincing studies proved that probiotic supplementation reduced asthma severity in children with pre-existing asthma [ 47 , 48 , 49 ].…”
Section: The Relevance Of Propam Study In Asthma Managementmentioning
A type-2 immune response usually sustains wheezing and asthma in children. In addition, dysbiosis of digestive and respiratory tracts is detectable in patients with wheezing and asthma. Probiotics may rebalance immune response, repair dysbiosis, and mitigate airway inflammation. As a result, probiotics may prevent asthma and wheezing relapse. There is evidence that some probiotic strains may improve asthma outcomes in children. In this context, the PROPAM study provided evidence that two specific strains significantly prevented asthma exacerbations and wheezing episodes. Therefore, oral probiotics could be used as add-on asthma therapy in managing children with asthma, but the choice should be based on documented evidence.
“…As reported by Hassanzad et al [316], no statistically significant clinical outcomes were observed after synbiotics were added to asthma management in a population of Iranian children younger than 12 years.…”
Section: Probiotics Prebiotics and Synbiotics: Prevention And Treatmentmentioning
confidence: 61%
“…Lastly, the roles of probiotics, prebiotics, and synbiotics appear to reduce the respiratory inflammatory pattern via the gut-lung axis, but their role in the prevention and treatment of asthma is questionable due to the connection between the gut and lung microbiomes [303][304][305][306][307][308][309][310][311][312][313][314][315][316]319]. In order to describe the role of dietary supplements (such as fish oil, vitamins, probiotics, prebiotics, and synbiotics) in preventing and improving asthma management in children, further studies are necessary.…”
Childhood obesity rates have dramatically risen in numerous countries worldwide. Obesity is likely a factor in increased asthma risk, which is already one of the most widespread chronic respiratory pathologies. The pathogenic mechanism of asthma risk has still not yet been fully elucidated. Moreover, the role of obesity-related inflammation and pulmonary overreaction to environmental triggers, which ultimately result in asthma-like symptoms, and the importance of dietary characteristics is well recognized. Diet is an important adjustable element in the asthma development. Food-specific composition of the diet, in particular fat, sugar, and low-quality nutrients, is likely to promote the chronic inflammatory state seen in asthmatic patients with obesity. An unbalanced diet or supplementation as a way to control asthma more efficiently has been described. A personalized dietary intervention may improve respiratory symptoms and signs and therapeutic response. In this narrative review, we presented and discussed more recent literature on asthma associated with obesity among children, focusing on the risk of asthma among children with obesity, asthma as a result of obesity focusing on the role of adipose tissue as a mediator of systemic and local airway inflammation implicated in asthma regulation, and the impact of nutrition and nutrients in the development and treatment of asthma. Appropriate early nutritional intervention could possibly be critical in preventing and managing asthma associated with obesity among children.
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