Synbiotic Therapy Reduces the Pathological Gram-Negative Rods Caused by an Increased Acetic Acid Concentration in the Gut

Hayakawa, Mineji; Asahara, Takashi; Ishitani, Toshiteru; Okamura, Atsushi; Nomoto, Koji; Gando, Satoshi

doi:10.1007/s10620-012-2201-9

Cited by 16 publications

(8 citation statements)

References 32 publications

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“…This takes the form of defense against bacterial translocation and infectious complications in seriously ill patients, including perioperative patients with bile duct cancer (21,39), esophageal cancer (51,52), hepatic cirrhosis (53), and colorectal cancer (54), patients undergoing cancer chemotherapy (55), systemic inflammatory response syndrome (SIRS) patients (40), and patients on long-term mechanical ventilation (56). Moreover, research has suggested that improvement of dysbiosis and activity to improve the intestinal environment (pH and organic acid [acetic acid] level) are important in the mechanism for this protective effect against infections.…”

Section: Figmentioning

confidence: 99%

Protective Effect of a Synbiotic against Multidrug-Resistant Acinetobacter baumannii in a Murine Infection Model

Asahara

Takahashi

Yuki

et al. 2016

Antimicrob Agents Chemother

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Section: Figmentioning

confidence: 99%

Protective Effect of a Synbiotic against Multidrug-Resistant Acinetobacter baumannii in a Murine Infection Model

Asahara

Takahashi

Yuki

et al. 2016

Antimicrob Agents Chemother

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“…Microaspiration of oropharyngeal secretions contaminated by endogenous flora around the endotracheal tube cuff is the major route for microbial invasion. The stomach and sinuses are postulated as the potential reservoir of certain bacterial colonizing the oropharynx [5]. Colonization of the endotracheal tube with bacteria encased in biofilm results in embolization into the alveoli during suctioning or bronchoscopy while inhalation of pathogens from contaminated aerosols, and direct inoculation are less common.…”

Section: Introductionmentioning

confidence: 99%

Probiotics for Preventing Ventilator-Associated Pneumonia: A Systematic Review and Meta-Analysis of High-Quality Randomized Controlled Trials

et al. 2013

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BackgroundVentilator-associated pneumonia (VAP) is considered to be a worldwide issue along with the development of supportive ventilation. The preventing strategy is of great importance for its poor prognostic and difficulties in treatment. Probiotics have been advocated as one of the possible preventive measures. We conducted a systematic review and meta-analysis to explore the potential benefits of probiotics.MethodsThe databases, Web of science, PubMed, Ovid and Cochrane lib were searched for randomized controlled trials (RCTs) publications that compared the effectiveness of probiotics with placebo in the prevention of VAP. The incidence of VAP was considered as the primary endpoint, mortality, length of stay in intensive care units (ICUs), etiology of the infections were considered as secondary endpoints.ResultsA total of 844 patients from 5 trials were subjected to meta-analysis. Probiotics did not significantly decrease the incidence of VAP (RR 0.94, 95%CI 0.85-1.04, p=0.22), however, the administration of probiotics reduced the risk of VAP caused by Pseudomonas aeruginosa (P. aeruginosa) (RR 0.30, 95%CI 0.11-0.91, P=0.03). It failed to affect any other endpoints.ConclusionProbiotic prophylaxis of ventilator-associated pneumonia remained inconclusive and it failed to improve the prognosis of general mechanically ventilated patients. It was noteworthy that infections caused by P. aeruginosa was reduced by administration of probiotics. In further, it is recommended that advanced studies should exploit transformation in pathogenic microorganisms owing to administration of probiotics as well as the specific population.

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“…They also maintain the acidity of the intestine and suppress the growth of harmful bacteria. Acetic acid, which is the most common organic acid, has an antimicrobial effect on harmful bacteria [18] and promotes the defensive functions of [21]. Thus, maintaining the concentration of SCFAs prior to iatrogenic gastrointestinal tract damage is useful for preventing bacterial translocation.…”

Section: Discussionmentioning

confidence: 99%

Impact of preoperative fecal short chain fatty acids on postoperative infectious complications in esophageal cancer patients

et al. 2020

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Background: The intestinal epithelial barrier allows absorption of dietary nutrients and prevents passage of pathogens and toxins into the body. Severe insults have a negative impact on the intestinal environment, which may decrease intestinal barrier function and cause bacterial translocation. Bacterial translocation, which can cause infectious complications, is defined as the passage of microbes from the gastrointestinal tract across the mucosal barrier to extraintestinal sites. The aim of this study was to investigate the correlation between concentrations of preoperative fecal organic acids and the occurrence of postoperative infectious complications in patients with esophageal cancer. Methods: Fifty-five patients with esophageal cancer who underwent esophagectomy were enrolled in this study. Perioperative synbiotics were administered to all patients. Perioperative clinical characteristics and concentrations of preoperative fecal organic acids were compared between patients with and without postoperative infectious complications. Results: Postoperative infectious complications occurred in 10 patients. In patients with complications, the concentrations of acetic acid and propionic acid were significantly lower than in patients without complications (p = 0.044 and 0.032, respectively). The concentration of butyric acid was nonsignificantly lower in patients with complications, while the concentration of lactic acid was nonsignificantly higher. The calculated gap between the concentrations of fecal acetic acid plus propionic acid plus butyric acid minus lactic acid was significantly lower in patients with complications. Multivariate analysis revealed that a low gap between acetic acid plus propionic acid plus butyric acid minus lactic acid was an independent risk factor for postoperative infectious complications (p = 0.027).

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Synbiotic Therapy Reduces the Pathological Gram-Negative Rods Caused by an Increased Acetic Acid Concentration in the Gut

Abstract: BackgroundThe mechanisms for the improvement of the gut flora and the

Cited by 16 publications

References 32 publications

Protective Effect of a Synbiotic against Multidrug-Resistant Acinetobacter baumannii in a Murine Infection Model

Protective Effect of a Synbiotic against Multidrug-Resistant Acinetobacter baumannii in a Murine Infection Model

Probiotics for Preventing Ventilator-Associated Pneumonia: A Systematic Review and Meta-Analysis of High-Quality Randomized Controlled Trials

Impact of preoperative fecal short chain fatty acids on postoperative infectious complications in esophageal cancer patients

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