Synbiotic Therapy: A Promising New Adjunctive Therapy for Ulcerative Colitis

Haskey, Natasha; Dahl, Wendy J.

doi:10.1111/j.1753-4887.2006.tb00196.x

Cited by 15 publications

(12 citation statements)

References 29 publications

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“…Strains R0011, R0052, R0175 and R0187 were selected because of their potential to improve health by modulating the immune system (Easo, Measham, Munroe, & Green-Johnson, 2002;Wallace, Bradley, Buckley, & Green-Johnson, 2003;Wood, Keeling, Bradley, Johnson-Green, & Green-Johnson, 2007), preventing infection (Johnson-Henry et al, 2004;JohnsonHenry et al, 2005) reducing the symptoms of stress (Gareau, Jury, MacQueen, Sherman, & Perdue, 2007;Zareie et al, 2006) and producing bioactive compounds (Fiander, Bradley, Johnson-Green, & Green-Johnson, 2005). In clinical trials, these microbes have been used to treat acute gastrointestinal infections (Kocian, 1994), reduce pain and bloating associated with irritable bowel syndrome (Benes, Kretk, & Tompkins, 2006) and maintain remission in patients with ulcerative colitis (Haskey & Dahl, 2006). The data support the definition of these strains as probiotics.…”

Section: Culturesmentioning

confidence: 98%

Selection of probiotic bacteria for the fermentation of a soy beverage in combination with Streptococcus thermophilus

Champagne

Green-Johnson

Raymond

et al. 2009

Food Research International

116

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Section: Culturesmentioning

confidence: 98%

Selection of probiotic bacteria for the fermentation of a soy beverage in combination with Streptococcus thermophilus

Champagne

Green-Johnson

Raymond

et al. 2009

Food Research International

116

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“…The effects of synbiotic therapies on intestinal function of different types of critically ill patients have been investigated in a few studies including infants 10 and adults. 11,12 Synbiotics have also proved useful in short bowel syndrome, 13,14 ulcerative colitis, [15][16][17] and acute pancreatitis, 18 although some of these are only preliminary studies without a control group.…”

Section: Introduction Smentioning

confidence: 99%

Beneficial Effects of a Synbiotic Supplement on Self-Perceived Gastrointestinal Well-Being and Immunoinflammatory Status of Healthy Adults

Nova

Viadel

Wärnberǵ

et al. 2011

Journal of Medicinal Food

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The use of synbiotics as health promoters is still poorly defined, and human intervention studies are scarce. This study was designed to evaluate the effects of a commercialized synbiotic product containing Lactobacillus acidophilus La5, Bifidobacterium animalis ssp. lactis Bb-12, Lactobacillus delbrueckii ssp. bulgaricus, Lactobacillus paracasei ssp. paracasei, Streptococcus thermophilus, and fructooligosaccharides on the self-reported gastrointestinal well-being and the immunoinflammatory status of healthy human subjects. In this randomized, double-blind, placebo-controlled study, 20 women and 16 men (25-45 years old) received either three tablets per day of the synbiotic product (2.4Â10 9 colony-forming units=day) or placebo during 6 weeks. Gastrointestinal symptoms and bowel habits were evaluated through a self-administered questionnaire. In those subjects suffering from any kind of digestive disturbance (mild dyspepsia, flatulence, postprandial bloating, constipation, etc.), improvements in symptoms after product consumption were also evaluated. Blood lymphocyte subsets, phagocytic activity, serum C-reactive protein, ceruloplasmin, and adhesion molecules concentrations were analyzed prior and after treatment. A significant improvement in overall self-reported gastrointestinal symptoms and bowel habit was found in the synbiotic group. A marginal effect of treatment (analysis of variance P ¼ .050) was observed with L-selectin, which showed a significant decrease in the synbiotic group (P ¼ .019). In addition, basal L-selectin levels correlated with final intercellular adhesion molecule (ICAM)-1 levels (r ¼ 0.468; P ¼ .050), and basal ICAM-1 levels tended to correlate negatively with final L-selectin concentration (r ¼ -0.457; P ¼ .056). None of these correlations was found in the placebo group. The rest of the immunological parameters studied were not modified by the intervention. In conclusion, consumption of the synbiotic product improves self-perceived bowel habits and might facilitate a better profile of adhesion molecules in healthy adults.

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“…The probiotic research where gastroenterology, immunology and microbiology intersect is very dynamic in both basic and clinical fields. Pursuit in knowing the complex molecular mechanisms that lead to the efficacy of probiotics could also stimulate the development of greater success in the formation of probiotics [41][42][43] .…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Symbiotics in an Experimental Model of Endotoxic Shock Induced by Lipopolysaccharide from Escherichia Coli

Ortíz¹

2016

IJFNS

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Obsevation: Endotoxic shock is a life-threatening condition and its sequelae represent an array of clinical symptoms that encompass systemic inflammation, coagulopathy, and abnormalities of the renal, hepatic, pulmonary and hematologic systems, followed by multi-organ failure. Furthermore, systemic failure leads to an unfavorable environment in the gut that causes an imbalance in the homeostasis of intestinal microbiota. In the present study, the effect of symbiotics as adjuvant therapy in endotoxic shock was investigated. Adult male Wistar rats were randomized into three groups: Control group received a single intraperitoneal injection of physiological saline solution, and the other two groups received either a symbiotic formulation or a placebo daily, for one week, followed by the administration of a single lethal dose of lipopolysaccharide (LPS) from E. coli (20 mg/Kg, IP). Results: The symbiotic formulation used improved the survival rate of LPS-treated rats, ameliorated the clinical symptomatology, reduced the production of serum proinflammatory cytokines (TNF-α, IL-6, IL-1β), and preserved the mitochondrial membrane fluidity and ATPase activity. Conclusion: The symbiotic formulation used as a pre-treatment in this experimental model, reduced mortality and showed beneficial effects at the systemic and sub-cellular levels.

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Synbiotic Therapy: A Promising New Adjunctive Therapy for Ulcerative Colitis

Cited by 15 publications

References 29 publications

Selection of probiotic bacteria for the fermentation of a soy beverage in combination with Streptococcus thermophilus

Selection of probiotic bacteria for the fermentation of a soy beverage in combination with Streptococcus thermophilus

Beneficial Effects of a Synbiotic Supplement on Self-Perceived Gastrointestinal Well-Being and Immunoinflammatory Status of Healthy Adults

Efficacy of Symbiotics in an Experimental Model of Endotoxic Shock Induced by Lipopolysaccharide from Escherichia Coli

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