Synbiotic Supplementation Improves Obesity Index and Metabolic Biomarkers in Thai Obese Adults: A Randomized Clinical Trial

Abstract

The cluster of metabolic disorders includes obesity, dyslipidemia, hypertension, and glucose intolerance, increasing the risk of developing cardiovascular diseases and type 2 diabetes. Evolving proofs suggest an essential role of microbiota in human health and disease, including digestion, energy and glucose metabolism, immunomodulation, and brain function. The frequency of overweight is increasing, and the main causes for this are highly processed foods and less active lifestyles. Research is underway to unravel the probable relationship between obesity and intestinal microbiota. Here, we propose a method to understand and elucidate the synergistic function of prebiotics and probiotics in treating obesity. The biomarkers of obesity, such as cholesterol, gut permeability, oxidative stress, bacterial toxins, cytokines, and short-chain fatty acids, were analyzed in Thai obese individuals after being supplemented with a synbiotic preparation containing Lactobacillus paracasei, Bifidobacterium longum, Bifidobacterium breve, inulin, and fructooligosaccharide. The results reveal that the supplementation of synbiotics significantly altered the obesity-associated biomarkers in an appositive way. Further studies are warranted to use synbiotics as an adjuvant therapy for the management of obesity-related health issues.

Probiotics Supplementation Improves Intestinal Permeability, Obesity Index and Metabolic Biomarkers in Elderly Thai Subjects: A Randomized Controlled Trial

“…In contrast, IgA levels were increased in human subjects significantly. These results suggested that synbiotic intervention could improve obesity-associated biomarkers [17].…”

“…The supplementation of L. paracasei HII01 increased the levels of short-chain fatty acids in obese, hypercholesterolemic, and diabetic human subjects [17,37]. 5-HIAA and QA/5-HIAA ratio was not significantly affected by the supplementation of L. paracasei HII01, B. breve, B. longum, inulin, and fructooligosaccharide.…”

“…Fecal short-chain fatty acids content was determined using high-performance liquid chromatography (HPLC) as described previously [17,21,22].…”

“…Probiotics are the most recognized method to improve gut microbiota and treat dysbiosis [12][13][14]. The studies reported that the probiotics had enhanced the homeostasis of intestinal permeability [15], reduced inflammation [16], and also improved several ill-health conditions in humans [17,18]. However, the mechanism behind the beneficial effect of probiotics on health benefits is not explored.…”

Using Microbiome-Based Approaches to Deprogram Chronic Disorders and Extend the Healthspan Following Adverse Childhood Experiences

“…Among the changes seen, both inflammatory and oxidative stress biomarkers improved with the symbiotic supplement. [182] Bifidobacterium longum and the prebiotic, galacto-oligosaccharide A study in mice found that this orally administered symbiotic combination protected against UVB-photoaging of skin. [183] Weissella confusa CGMCC 19,30 A study in the bacterial infection C. elegans model found that this orallyadministered probiotic increased lifespan, improved immunity, and reduced oxidative stress [184] Lactobacillus paracasei GKS6 and Bifidobacterium lactis GKK2 were examined independently.…”