Synbiotic in the management of infantile colic: A randomised controlled trial

Kianifar, Hamidreza; Ahanchian, Hamid; Grover, Zubin; Jafari, Seyed Ali; Noorbakhsh, Zeinab; Khakshour, Ali; Sedaghat, Mohammad Reza; Kiani, Mohammadali

doi:10.1111/jpc.12640

Cited by 58 publications

(50 citation statements)

References 29 publications

(34 reference statements)

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“…Noteworthy, these results are in agreement with the in vitro studies on the antagonistic effects of the probiotic strains used [49], as well as with observational evidence on the relationship between infant colic and microbiome diversity, Enterobacterial abundance and Bifidobacterial abundance [12,19]. [51,52]. Positive effects where observed already on day 7; however, the positive effect of the probiotic vs. placebo had disappeared after 30 days of treatment.…”

Section: Archives Of Clinical Microbiology Issn 1989-8436supporting

confidence: 79%

Gut Microbiota Dysbiosis and Role of Probiotics in Infant Colic

Tintore¹,

Colomé²,

Santas³

et al. 2017

Arch Clin Microbiol

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Infant colic or excessive crying syndrome is a behavioral syndrome in 1-to 5-month-old infants involving long periods of inconsolable crying and fussing in otherwise healthy infants. Its etiology is unclear, but evidence regarding the implications of the infant gut microbiota is rising in importance.In this short review, we aim to expose recent findings on alterations in the microbiota of colicky infants which could trigger or facilitate infant colic, and summarize the clinical and mechanistical evidence of several probiotic formulations for the management of infant colic.The observed increase in the relative abundance of Enterobacteria in colicky babies may facilitate intestinal hypersensitivity due to their endotoxins, while also increasing the amount of intestinal gas, and thus, bloating and digestive discomfort. Also, an association between infant colic and a decrease in the relative abundance of protective bacterial groups such as bifidobacteria or lactobacilli has been pointed out by independent research groups. Therefore, it is not surprising that many clinical trials have explored the effects of supplementing the microbiota of colicky infants with probiotics due to their known effect in modulating gastrointestinal microbiota.

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Section: Archives Of Clinical Microbiology Issn 1989-8436supporting

confidence: 79%

Gut Microbiota Dysbiosis and Role of Probiotics in Infant Colic

Tintore¹,

Colomé²,

Santas³

et al. 2017

Arch Clin Microbiol

View full text Add to dashboard Cite

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“…The characteristics of the seven included RCTs [9–15] that recruited a total of 471 infants are summarized in Table I. With one exception [13], all trials were double-blind and placebo controlled.…”

Section: Resultsmentioning

confidence: 99%

Probiotics for management of infantile colic: a systematic review of randomized controlled trials

Dryl

Szajewska

2018

aoms

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IntroductionInfantile colic is a common pediatric problem. The cause of infantile colic remains unclear. Treatment options are limited. Evidence suggests that probiotics might offer some benefit. The aim of the study was to systematically assess the effectiveness of probiotics supplementation in the management of infantile colic.Material and methodsMEDLINE and the Cochrane Library were searched up to April 2016 for randomized controlled trials (RCTs) evaluating the efficacy of probiotics (any well-defined strain) compared with placebo for the management of infantile colic. The outcome measures of interest were treatment success and the duration of crying at the end of the intervention.ResultsSeven RCTs (471 participants) were included. Compared with placebo the administration of Lactobacillus reuteri DSM 17938 at a daily dose of 108 CFU was associated with the treatment success (relative risk = 1.67, 95% CI: 1.10–2.81, number needed to treat 5, 95% CI: 4–8) and reduced crying times at the end of the intervention (mean difference: –49 min, 95% CI: –66 to –33); however, the effect was mainly seen in exclusively breastfed infants. Other probiotics (single or in combinations) were studied in single trials only.ConclusionsSome probiotics, primarily L. reuteri DSM 17938, may be considered for the management of infantile colic. Data on other probiotics are limited.

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“…He compared with the placebo and found out that there was a reduction of >50% in crying time among 87 % of infants in synbiotic group and 46 % of infants in placebo group at 30 days (P<0.01). (13) Importance of type and number of probiotic strains The beneficial effects of synbiotics depends on the type of strains, number of strains and duration of intervention. kianifer et al in 2014 in his study used a probiotic strain with 109 CFU combined with prebiotics -fructooligosaccharides.…”

Section: Resultsmentioning

confidence: 99%

“…kianifer et al in 2014 in his study used a probiotic strain with 109 CFU combined with prebiotics -fructooligosaccharides. (13) Compared to this study, in the present study we used a synbiotic with a combination of dose of lactobacillus sporogenes 5×10 7 , Streptococcus faecalis 3 ×10 7 , Clostridium butyricum 2×10 6 and Bacillus mesentericus 1×10 6 CFU.…”

Section: Resultsmentioning

confidence: 99%