Synaptosome behaviour is unaffected by weak pulsed electromagnetic fields

Aldinucci, Carlo; Carretta, A.; Maiorca, Silvia Maria; Rossi, Viviana; Ciccoli, Lucia; Pessina, G. P.

doi:10.1002/bem.20322

Cited by 3 publications

(1 citation statement)

References 34 publications

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“…Similarly, the results of our study demonstrated that ELF-EMF (100mT/1 Hz for 5 days, 120 min each day) causes in vitro apoptosis in the mentioned cell line (Figure 1). In 2007, Aldinucci also observed increased induction of apoptosis in human cancer cells after exposure to radiation of 50 Hz EMF magnetic field of 1 mT [32]. Similar results were obtained in a study on the MCF-7 cell line and the normal MCF-10 cell line at 20 Hz; using an EMF of 2,3,5 mT for 60 minutes [33].…”

Section: Discussionsupporting

confidence: 63%

1Hz and 100mT Electromagnetic Field Induces Apoptosis in Breast Cancer Cells Through Up-Regulation of P38 and P21

Barati¹,

Fahimi²,

Farahmand³

et al. 2020

Multidiscip Cancer Investig

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Introduction: Breast cancer is the most common cause of cancer-related death among women. Recently, extremely low-frequency electromagnetic field (ELF-EMF) has been proposed as a new interfering agent with future therapeutic potentials. Many studies have revealed that cellular processes such as apoptosis in breast cancer are affected by ELF-EMFs. However, more researches are needed to clarify the underlying mechanism of action for these fields. In this study, the apoptotic effect of ELF-EMF on the MC4L2 cell line was examined and the mRNA expression level of the P21 and P38 genes were further investigated. Methods: A triple-positive mouse breast cancer cell line (MC4L2) was purchased from the Genetic Resource Center (Iran). This study was performed on two groups of ELF-EMF exposure (100mT/1 Hz for 5 days, 120 min each day) and sham exposure. Cell viability and apoptosis rate of both the exposure and sham exposure groups weredetermined by flow cytometry. Alterations in the P21 and P38 mRNAs expression levelswere investigated; using real-time PCR. Results: ELF-EMF exposure induced 30% apoptosis in MC4L2 cells compared with the control group. The mRNA expression level of P38 and P21 was significantly increased after ELF-EMF exposure compared to the control group. Conclusions: ELF-EMF induces apoptosis in the MC4L2 triple-positive cell line. Furthermore, this exposure affects important gene expression involved in the cell cycle. Our data propose that ELF-EMF in a specific time, intensity, and frequency could be beneficial for breast cancer treatment. However, more studies are required to confirm our findings.

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Section: Discussionsupporting

confidence: 63%