Synaptophysin in the Cochlear Nucleus Following Acoustic Trauma

Muly, S.M.; Gross, J.; Morest, D. Kent; Potashner, S.J.

doi:10.1006/exnr.2002.7963

Cited by 56 publications

(73 citation statements)

References 95 publications

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“…5D). These results indicate that noise exposure used in the present study inhibited expression of synaptophysin in the DCN with a regional specific pattern, probably reflecting degeneration of synaptic endings following acute acoustic trauma (AAT, Muly et al, 2002), and that antioxidant treatment significantly restores its expression in the DCN. Positive synaptophysin staining was also found in the VCN as reported (Gil-Loyzaga et al, 1998).…”

Section: Antioxidant Treatment Restored Expression Of Synaptophysin Imentioning

confidence: 69%

“…Decreased expression of synaptophysin was found in the VCN following AAT or cochlear ablation (Benson et al, 1997;FuentesSantamaría et al, 2007;Muly et al, 2002). Precerebellin (Cbln1), the precursor of the brain-specific neuropeptide cerebellin, is a synapse organizer for both pre-and post-synaptic components and is involved in synaptic integrity, plasticity, as well as synapse maintenance in the cerebellum (Hirai et al, 2005;Ito-Ishida et al, 2008;Matsuda et al, 2010;Miura et al, 2009).…”

Section: Effects Of Noise Exposure and Antioxidant Treatment On Synapmentioning

confidence: 96%

“…Axon and synapse degeneration were found in the central auditory system after relatively low level octave-band noise exposure (108 dB SPL for 3 h, Muly et al, 2002;Kim et al, 1997Kim et al, , 2004a. Degeneration of axonal and synaptic endings in the CN could result from a dystrophic mechanism or an excitotoxic mechanism or a trans-synaptic process (Kim et al, , 2004b.…”

Section: Tonotopic Synapse Degeneration In the Dcn And Effects Of Antmentioning

confidence: 98%

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Selective degeneration of synapses in the dorsal cochlear nucleus of chinchilla following acoustic trauma and effects of antioxidant treatment

Chen

Choi

et al. 2012

Hearing Research

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Section: Antioxidant Treatment Restored Expression Of Synaptophysin Imentioning

confidence: 69%

Section: Effects Of Noise Exposure and Antioxidant Treatment On Synapmentioning

confidence: 96%

Section: Tonotopic Synapse Degeneration In the Dcn And Effects Of Antmentioning

confidence: 98%

See 1 more Smart Citation

Selective degeneration of synapses in the dorsal cochlear nucleus of chinchilla following acoustic trauma and effects of antioxidant treatment

Chen

Choi

et al. 2012

Hearing Research

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“…More relevant to the present work are studies in which acoustic trauma was used. Following trauma, degeneration of axons and cells in the cochlear nucleus occurs (Bilak et al, 1997;Muly et al, 2002;Kim et al, 2004b;Muly et al, 2004). The initial loss includes both excitatory and inhibitory synapses, but there is a return of excitatory synapses and of glutamate release and uptake, without a corresponding increase in inhibitory synapses.…”

Section: Mechanisms Of the Tail Responsementioning

confidence: 99%

“…Although the lesions produced by acoustic trauma are in the cochlea, secondary effects in the central nervous system may be important in determining the perceptual consequences of trauma (reviewed by Syka, 2002). Central effects of cochlear damage or ablation include degeneration of axons and neurons (Born and Rubel, 1988;Morest et al, 1998;Redd et al, 2000;Muly et al, 2002), formation of new synaptic connections (Kim et al, 2004a;Muly et al, 2004), rewiring of central circuits (Nordeen et al, 1983;Rajan et al, 1993;Leake et al, 2000), and changes in synaptic strength to favor excitation over inhibition (Suneja et al, 1998a;Abbott et al, 1999;Milbrandt et al, 2000;Mossop et al, 2000;Oleskevich and Walmsley, 2002;Vale and Sanes, 2002;Kim et al, 2004a). Each of these could influence substantially the central representation of sound.…”

Section: Introductionmentioning

confidence: 99%

Dorsal cochlear nucleus response properties following acoustic trauma: Response maps and spontaneous activity

Young

2006

Hearing Research

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Recordings from single neurons in the dorsal cochlear nucleus (DCN) of unanesthetized (decerebrate) cats were done to characterize the effects of acoustic trauma. Trauma was produced by a 250 Hz band of noise centered at 10 kHz, presented at 105-120 dB SPL for 4 h. After a one-month recovery period, neurons were recorded in the DCN. The threshold shift, determined from compound actionpotential audiograms, showed a sharp threshold elevation of about 60 dB at BFs above an edge frequency of 5-10 kHz. The response maps of neurons with best frequencies (BFs) above the edge did not show the typical organization of excitatory and inhibitory areas seen in the DCN of unexposed animals. Instead, neurons showed no response to sound, weak responses that were hard to tune and characterize, or "tail" responses, consisting of broadly-tuned, predominantly excitatory responses, with a roughly low-pass shape similar to the tuning curves of auditory nerve fibers with similar threshold shifts. In some tail responses whose BFs were near the edge of the threshold elevation, a second weak high-frequency response was seen that suggests convergence of auditory nerve inputs with widely separated BFs on these cells. Spontaneous rates among neurons with elevated thresholds were not increased over those in populations of principal neurons in unexposed animals.

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Quantitative changes in calretinin immunostaining in the cochlear nuclei after unilateral cochlear removal in young ferrets

Fuentes–Santamaría

Alvarado

Taylor

et al. 2005

J of Comparative Neurology

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Neurons of the cochlear nuclei receive axosomatic endings from primary afferent fibers from the cochlea and have projections that diverge to form parallel ascending auditory pathways. These cells are characterized by neurochemical phenotypes such as levels of calretinin. To test whether or not early deafferentation results in changes in calretinin immunostaining in the cochlear nucleus, unilateral cochlear ablations were performed in ferrets soon after hearing onset (postnatal day [P]30-P40). Two months later, changes in calretinin immunostaining as well as cell size, volume, and synaptophysin immunostaining were assessed in the anteroventral (AVCN), posteroventral (PVCN), and dorsal cochlear nucleus (DCN). A decrease in calretinin immunostaining was evident ipsilaterally within the AVCN and PVCN but not in the DCN. Further analysis revealed a decrease both in the calretinin-immunostained neuropil and in the calretinin-immunostained area within AVCN and PVCN neurons. These declines were accompanied by significant ipsilateral decreases in volume as well as neuron area in the AVCN and PVCN compared with the contralateral cochlear nucleus and unoperated animals, but not compared with the DCN. In addition, there was a significant contralateral increase in calretinin-immunostained area within AVCN and PVCN neurons compared with control animals. Finally, a decrease in area of synaptophysin immunostaining in both the ipsilateral AVCN and PVCN without changes in the number of boutons was found. The present data demonstrate that unilateral cochlear ablation leads to 1) decreased immunostaining of the neuropil in the AVCN and PVCN ipsilaterally, 2) decreased calretinin immunostaining within AVCN and PVCN neurons ipsilaterally, 3) synaptogenesis in the AVCN and PVCN ipsilaterally, and 4) increased calretinin immunostaining within AVCN and PVCN neurons contralaterally.

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Synaptophysin in the Cochlear Nucleus Following Acoustic Trauma

Cited by 56 publications

References 95 publications

Selective degeneration of synapses in the dorsal cochlear nucleus of chinchilla following acoustic trauma and effects of antioxidant treatment

Selective degeneration of synapses in the dorsal cochlear nucleus of chinchilla following acoustic trauma and effects of antioxidant treatment

Dorsal cochlear nucleus response properties following acoustic trauma: Response maps and spontaneous activity

Quantitative changes in calretinin immunostaining in the cochlear nuclei after unilateral cochlear removal in young ferrets

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