Synaptic transmission molecules and their role in the pathogenesis of allergic rhinitis

Klimov, Andrew; Kalyuzhin, O. V.; Klimov, Vladimir V.; Naidina, O. A.

doi:10.20538/1682-0363-2021-4-143-152

Cited by 2 publications

(1 citation statement)

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“…15,71 Predominant protolerogenic neuro molecules are norepinephrine, serotonin, γ-aminobutyric acid (GABA) (except for a small exclusion in relation to goblet cells), glycine, CGRP, VIP, endocannabinoids, and some others. 2, 72 However, CGRP and VIP can display ambivalent effects. Destroyed communication between the nervous and immune systems and imbalance of pro-immunogenic and protolerogenic neuro molecules is a common feature in immunopathological disorders.…”

Section: The Physiological Maintenance Of Tolerance To Allergens In T...mentioning

confidence: 99%

Autonomous Breakdown of the Allergen Tolerance in the Nose: A Hypothesis

Klimov¹,

Klimov²,

Кошкарова³

2022

Explor Res Hypothesis Med

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The prevalence of conventional and new pathogenic types of allergies is increasing. For the last few years, new atopic disorders -local allergic rhinitis (LAR), local allergic asthma, "dual" allergic rhinitis, and local allergic conjunctivitis -have been described. In particular, LAR was identified a decade ago, whereas its immunopathogenesis is still unclear. Nevertheless, the network of immune cells and neurons determining the maintenance or breakdown of allergen tolerance has partially been studied. Therefore, this field of research is currently at the cutting edge. However, there is still not any definitive answer as to why local disorders take place. Specifically, the nasal cavity is characterized by the following prevalent neuro molecules: acetylcholine, norepinephrine, substance P, neuromedin U, vasoactive intestinal peptide, and calcitonin-gene-related peptide; some of which are pro-immunogenic and a slightly smaller part is protolerogenic. In the spotlight, the hypothesis of an autonomous breakdown of tolerance to allergens in LAR is presented. The article describes immune tolerance as the antipode of the active immune response, which does not lead to producing effector cells and molecules, and vice versa is based on active immunosuppressive processes. In addition, this article focuses on the mechanisms of the maintenance and breakdown of allergen tolerance, a form of immune tolerance, at the nasal level and throughout the body, and the essential role of various cells and molecules, including neuro molecules, in the pathogenesis of LAR.

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Section: The Physiological Maintenance Of Tolerance To Allergens In T...mentioning

confidence: 99%