Synaptic Responses Evoked by Lower Urinary Tract Stimulation in Superior Cervical Ganglion Cells in the Rat

Häbler, Heinz-Joachim; McLachlan, Elspeth M.; Jamieson, John; Davies, Philip

doi:10.1016/s0022-5347(05)69001-5

Cited by 7 publications

(4 citation statements)

References 24 publications

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“…Controversial results were reported concerning the activity of afferent neurons in the urinary tract evoked by bladder distension, which could trigger both excitatory and inhibitory reflexes (Habler et al 1999). Different bladder afferent activity was shown by the cuff electrode recordings from pelvic nerve during the changes in bladder pressure (Rocha et al 2001, Jezernik et al 2000.…”

Section: Urinary Bladder Experimentsmentioning

confidence: 99%

“…Vascular disorders were studied by morphometry and immunohistochemistry (Matsumoto et al 2003). Activation of the afferent signals from the urinary bladder were examined with different methods, including systemic blood pressure and heart rate measurements, neurological study of reflexes, and direct recordings of neural activity (Mehnert et al 2009, Weaver 1985, Rocha et al 2001, Habler et al 1999, Jezernik et al 2000, Hubeaux et al 2007, Carly et al 2009. Thus, a lot of methods are known to individually study vesical neural activity and circulation in situ and in vitro.…”

Section: Introductionmentioning

confidence: 99%

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Bioimpedance harmonic analysis as a tool to simultaneously assess circulation and nervous control

Mudraya¹,

Revenko

Nesterov

et al. 2011

Physiol. Meas.

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Multicycle harmonic (Fourier) analysis of bioimpedance was employed to simultaneously assess circulation and neural activity in visceral (rat urinary bladder) and somatic (human finger) organs. The informative value of the first cardiac harmonic of the bladder impedance as an index of bladder circulation is demonstrated. The individual reactions of normal and obstructive bladders in response to infusion cystometry were recorded. The potency of multicycle harmonic analysis of bioimpedance to assess sympathetic and parasympathetic neural control in urinary bladder is discussed. In the human finger, bioimpedance harmonic analysis revealed three periodic components at the rate of the heart beat, respiration and Mayer wave (0.1 Hz), which were observed under normal conditions and during blood flow arrest in the hand. The revealed spectrum peaks were explained by the changes in systemic blood pressure and in regional vascular tone resulting from neural vasomotor control. During normal respiration and circulation, two side cardiac peaks were revealed in a bioimpedance amplitude spectrum, whose amplitude reflected the depth of amplitude respiratory modulation of the cardiac output. During normal breathing, the peaks corresponding to the second and third cardiac harmonics were split, reflecting frequency respiratory modulation of the heart rate. Multicycle harmonic analysis of bioimpedance is a novel potent tool to examine the interaction between the respiratory and cardiovascular system and to simultaneously assess regional circulation and neural influences in visceral and somatic organs.

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Section: Urinary Bladder Experimentsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Bioimpedance harmonic analysis as a tool to simultaneously assess circulation and nervous control

Mudraya¹,

Revenko

Nesterov

et al. 2011

Physiol. Meas.

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“…In vivo intracellular recording from the rabbit SCG (Skok and Ivanov, 1983) and rat SCG (McLachlan et al, 1997, 1998; Habler et al, 1999) has shown that naturally occurring subthreshold nicotinic EPSPs may contribute to postganglionic firing. Although consistent with the gain hypothesis, an alternative interpretation has been advanced.…”

Section: Introductionmentioning

confidence: 99%

Weak and straddling secondary nicotinic synapses can drive firing in rat sympathetic neurons and thereby contribute to ganglionic amplification

Rimmer

Horn

2010

Front. Neur.

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Interactions between nicotinic excitatory postsynaptic potentials (EPSPs) critically determine whether paravertebral sympathetic ganglia behave as simple synaptic relays or as integrative centers that amplify preganglionic activity. Synaptic connectivity in this system is characterized by an n + 1 pattern of convergence, where each ganglion cell receives one very strong primary input and a variable number (n) of weak secondary inputs that are subthreshold in strength. To test whether pairs of secondary nicotinic EPSPs can summate to fire action potentials (APs) and thus mediate ganglionic gain in the rat superior cervical ganglion, we recorded intracellularly at 34°C and used graded presynaptic stimulation to isolate individual secondary synapses. Weak EPSPs in 40 of 53 neurons had amplitudes of 0.5–7 mV (mean 3.5 ± 0.3 mV). EPSPs evoked by paired pulse stimulation were either depressing (n = 10), facilitating (n = 9), or borderline (n = 10). In 15 of 29 cells, pairs of weak secondary EPSPs initiated spikes when elicited within a temporal window <20 ms, irrespective of EPSP amplitude or paired pulse response type. In six other neurons, we observed novel secondary EPSPs that were strong enough to straddle spike threshold without summation. At stimulus rates <1 Hz straddling EPSPs appeared suprathreshold in strength. However, their limited ability to drive firing could be blocked by the afterhyperpolarization following an AP. When viewed in a computational context, these findings support the concept that weak and straddling secondary nicotinic synapses enable mammalian sympathetic ganglia to behave as use-dependent amplifiers of preganglionic activity.

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“…Changes in synaptic activity in various neurones of rat SCG occurred in response to cutaneous nociceptor stimulation (brief pinches, McLachlan et al 1997) and bladder distension (Häbler et al 1999), and were linked to respiration (McLachlan et al 1998) and/or changes in arterial blood pressure (Fig. 3).…”

Section: Intracellular Recording In Vivomentioning

confidence: 99%

Transmission of signals through sympathetic ganglia – modulation, integration or simply distribution?

McLachlan

2003

Acta Physiologica Scandinavica

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Synaptic Responses Evoked by Lower Urinary Tract Stimulation in Superior Cervical Ganglion Cells in the Rat

Cited by 7 publications

References 24 publications

Bioimpedance harmonic analysis as a tool to simultaneously assess circulation and nervous control

Bioimpedance harmonic analysis as a tool to simultaneously assess circulation and nervous control

Weak and straddling secondary nicotinic synapses can drive firing in rat sympathetic neurons and thereby contribute to ganglionic amplification

Transmission of signals through sympathetic ganglia – modulation, integration or simply distribution?

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