Synaptic relations of neurotensinergic neurons in the dorsal raphe nucleus

Wang, Qing Ping; Guan, Jian Lian; Nakai, Yasumitsu

doi:10.1016/0196-9781(95)02041-1

Cited by 7 publications

(2 citation statements)

References 38 publications

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“…As mentioned previously, both the DRN and NRM are clearly implicated in mediating antianalgesia, and NRM receives afferents from DRN (Fardin et al, 1984; Reichling & Basbaum, 1991; Yezierski et al, 1982). The DRN contains a high density of neurotensinergic neurons (Jennes, Stumpf, & Kalivas, 1982; Wang, Guan, & Nakai, 1995), and the NRM receives its major neurotensinergic input from the DRN (Beitz, 1982; Beitz, Shepard, & Wells, 1983; Sim & Joseph, 1993). This DRN–to–NRM neurotensinergic pathway is especially interesting in light of recent work by Urban and colleagues (Urban & Smith, 1993, 1994; Urban et al, 1996).…”

Section: Discussionmentioning

confidence: 99%

Neurocircuitry of conditioned inhibition of analgesia: Effects of amygdala, dorsal raphe, ventral medullary, and spinal cord lesions on antianalgesia in the rat.

Watkins¹,

Wiertelak²,

McGorry³

et al. 1998

Behavioral Neuroscience

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Pain inhibition (analgesia) is produced by learned danger signals and inhibited by learned safety signals (antianalgesia). Conditioned analgesia is mediated by brain-to-spinal pathways releasing spinal endogenous opiates. Spinal morphine mimics learned danger signals in producing analgesia, which is inhibited by antianalgesia. The circuitry mediating antianalgesia is unknown. These experiments demonstrate that raphe dorsalis, raphe magnus, and spinal dorsolateral funiculus lesions abolish antianalgesia. Other lesions had no effect on antianalgesia. More important, lesions that blocked development of conditioned analgesia did not block development of antianalgesia. Thus, neural circuitries mediating analgesia and antianalgesia were found to be distinct, and conditioned inhibition of analgesia was found to act by inhibiting the most distal part of the conditioned analgesia circuit, namely, the spinal cord.

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Section: Discussionmentioning

confidence: 99%

Neurocircuitry of conditioned inhibition of analgesia: Effects of amygdala, dorsal raphe, ventral medullary, and spinal cord lesions on antianalgesia in the rat.

Watkins¹,

Wiertelak²,

McGorry³

et al. 1998

Behavioral Neuroscience

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“…Wong and coworkers have published several articles on neuronal control by 5-HT and other neuronal transmitters in the RD [35][36][37][38]; however, to the best of our knowledge, there have been no reports of the coexistence of ChAT and aminergic neurons both in the RD and LC.…”

Section: Discussionmentioning

confidence: 99%

Choline Acetyltransferase Positive Neurons in the Laboratory Shrew (Suncus murinus) Brain: Coexistence of ChAT/5-HT (Raphe dorsalis) and ChAT/TH (Locus ceruleus)

Karasawa

Takeuchi

Yamada

et al. 2003

Acta Histochem. Cytochem

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We determined the distribution pattern of cholinergic neurons in laboratory shrews (Suncus murinus) based on comparative morphology by an immunohistochemical method using an anticholine acetyltransferase (ChAT) antibody. ChAT-positive neurons were observed in the striatum, magnocellular nucleus and basal nucleus, pontine tegmentum and cranial nerve motor nuclei (IV, V, VII, X and XII). Specific findings were as follows: many ChAT-positive neurons were observed in the locus ceruleus (LC) and raphe dorsalis (RD), and the colocalization of ChAT-positive neurons and tyrosine hydroxylase in the LC and that of ChAT-positive neurons and serotonin in the RD were clarified. On the other hand, in the rat brain, ChAT-positive neurons were present in the central amygdaloid nucleus; however, this was not observed in the brains of laboratory shrews. Laboratory shrews are among the most primitive mammalian species and have a different distribution pattern of aminergic neurons, other than cholinergic neurons, from that in rats. A unique distribution pattern of ChAT-positive neurons in the laboratory shrew brain was thus noted.

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Electron microscopic study of GABAergic synaptic innervation of neurotensin-immunoreactive neurons in the dorsal raphe nucleus

1996

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Synaptic relations of neurotensinergic neurons in the dorsal raphe nucleus

Cited by 7 publications

References 38 publications

Neurocircuitry of conditioned inhibition of analgesia: Effects of amygdala, dorsal raphe, ventral medullary, and spinal cord lesions on antianalgesia in the rat.

Neurocircuitry of conditioned inhibition of analgesia: Effects of amygdala, dorsal raphe, ventral medullary, and spinal cord lesions on antianalgesia in the rat.

Choline Acetyltransferase Positive Neurons in the Laboratory Shrew (Suncus murinus) Brain: Coexistence of ChAT/5-HT (Raphe dorsalis) and ChAT/TH (Locus ceruleus)

Electron microscopic study of GABAergic synaptic innervation of neurotensin-immunoreactive neurons in the dorsal raphe nucleus

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