Abstract:Background
Memory loss is central to Alzheimer’s disease (AD), but the precise underlying mechanisms remain unclear. Post‐mortem research suggests that synaptic loss best explains symptoms. Here, we investigated in cerebrospinal fluid (CSF) whether levels of synaptic proteins are related with memory scores in older individuals with normal cognition and in preclinical AD.
Method
Participants were selected from ADNI and EMIF‐AD MBD if they had CSF proteomics and memory scores available. In total, we selected 85 … Show more
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