Synaptic Plasticity: The New Explanation of Visceral Hypersensitivity in Rats with Trichinella spiralis Infection?

Yang, Xinquan; Lei, Sheng; Yang, Guan; Qian, Wei; Hou, Xiaohua

doi:10.1007/s10620-008-0444-2

Cited by 24 publications

(22 citation statements)

References 55 publications

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“…35 Several studies are now providing initial evidence suggesting the involvement of neuroplastic changes in the enteric nervous system or afferent pathways in functional gastrointestinal disorders, including IBS. 35,39 Infiltration of MCs in the colonic mucosa of patients with IBS promote neuronal sprouting and neuroplastic changes owing to the release of nerve growth factor. 40 Nerve growth factor acting on tropomyosin receptor kinase A (TrkA) receptors could also up-regulate of TRPV1 expression.…”

Section: Mast Cells Modulate Visceral Sensationmentioning

confidence: 99%

Mast Cells and Irritable Bowel Syndrome: From the Bench to the Bedside

Zhang

Song

Hou

2016

J Neurogastroenterol Motil

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110

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Irritable bowel syndrome (IBS) is traditionally defined as a functional disorder since it lacks demonstrable pathological abnormalities. However, in recent years, low grade inflammatory infiltration, often rich in mast cells, in both the small and large bowel, has been observed in some patients with IBS. The close association of mast cells with major intestinal functions, such as epithelial secretion and permeability, neuroimmune interactions, visceral sensation, and peristalsis, makes researchers and gastroenterologists to focus attention on the key roles of mast cells in the pathogenesis of IBS. Numerous studies have been carried out to identify the mechanisms in the development, infiltration, activation, and degranulation of intestinal mast cells, as well as the actions of mast cells in the processes of mucosal barrier disruption, mucosal immune dysregulation, visceral hypersensitivity, dysmotility, and local and central stress in IBS. Moreover, therapies targeting mast cells, such as mast cell stabilizers (cromoglycate and ketotifen) and antagonists of histamine and serotonin receptors, have been tried in IBS patients, and have partially exhibited considerable efficacy. This review focuses on recent advances in the role of mast cells in IBS, with particular emphasis on bridging experimental data with clinical therapeutics for IBS patients.

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Section: Mast Cells Modulate Visceral Sensationmentioning

confidence: 99%

Mast Cells and Irritable Bowel Syndrome: From the Bench to the Bedside

Zhang

Song

Hou

2016

J Neurogastroenterol Motil

Self Cite

110

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“…TEM was performed as previously described with some modifications . In brief, IEC‐18 cells were fixed with 2.5% phosphate‐buffered glutaraldehyde for 2 h and stored at 4°C until embedding.…”

Section: Methodsmentioning

confidence: 99%

Four types of Bifidobacteria trigger autophagy response in intestinal epithelial cells

Lin

Jiang

Zhao

et al. 2014

J of Digest Diseases

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“…For example, we found that synaptic plasticity in ENS of PI-IBS model rats infected with Trichinella spiralisis associated with visceral sensitivity. 7 Dorsal root ganglia neuron excitability was increased significantly in the PI-IBS model. 11 Others showed through functional magnetic imaging and positron emission tomography studies that brain areas involved in visceral sensation processing, such as the prefrontal cortex and cingulate cortex, were activated abnormally in IBS patients.…”

Section: Introductionmentioning

confidence: 93%

“…3 The possible mechanisms of PI-IBS include mucosal injury and inflammation, 4 increased intestinal permeability, 5 mast cell hyperplasia, 6 and enteric nerve alteration. 7,8 Abdominal pain is the most predominant and distressing symptom of PI-IBS. 9 Visceral hypersensitivity, which is generally considered to be a hallmark of IBS with lowered thresholds for pain and increased intensity of sensations, was responsible for the symptom.…”

Section: Introductionmentioning

confidence: 99%

Mast Cell-dependent Mesenteric Afferent Activation by Mucosal Supernatant From Different Bowel Segments of Guinea Pigs With Post-infectious Irritable Bowel Syndrome

Song

Zhang

Bai

et al. 2015

J Neurogastroenterol Motil

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Background/Aims Mesenteric afferent nerves (MANs) play a pivotal role in the visceral-nociceptive perception. Inappropriate activation of MANs may be involved in the pathogenesis of post-infectious irritable bowel syndrome (PI-IBS). However, the underlying mechanisms remain unclear. We assessed the effects of mucosal mediators from different bowel segments of guinea pigs with PI-IBS on MAN firing and the role of mast cells. Methods PI-IBS was induced in guinea pigs by Trichinella spiralis infection. Inflammation in terminal ileum, proximal and distal colon was scored with hematoxylin-eosin staining, and mast cell infiltration was assessed with immunofluorescence. We determined the effects of supernatant extracted from the mucosa of different bowel segments of PI-IBS on MANs activity, and assessed the role of mast cells in this process. Results Eight weeks after infection, intestinal inflammation resolved, whereas mast cell numbers increased significantly in terminal ileum and proximal colon ( P < 0.05) compared with findings in controls. Mucosal supernatant from different bowel segments of PI-IBS models, but not from controls, significantly enhanced the frequency of MAN firing (terminal ileum 41.01 ± 7.60 Hz vs. 26.55 ± 0.67 Hz, P = 0.001; proximal colon 45.90 ± 11.20 Hz vs. 30.88 ± 6.92 Hz, P = 0.002; distal colon 48.25 ± 9.70 Hz vs. 29.47 ± 6.13 Hz, P < 0.001). In addition, the excitatory effects were inhibited by mast cell stabilizer Nasmil (terminal ileum, 32.71 ± 2.52 Hz, P = 0.030; proximal colon, 30.94 ± 4.44 Hz, P = 0.002; distal colon, 27.15 ± 5.83 Hz, P < 0.001). Conclusions Supernatant from the intestinal mucosa of different bowel segments of PI-IBS models markedly enhanced the MAN firing in a mast cell-dependent manner, indicating that mast cell-mediated MAN activation plays an important role in the pathogenesis of PI-IBS.

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Synaptic Plasticity: The New Explanation of Visceral Hypersensitivity in Rats with Trichinella spiralis Infection?

Abstract: Synaptic plasticity was observed in SD rats infected by Trichinella spiralis and was associated with visceral sensitivity, which suggests that it may play an important role in the formation of visceral hypersensitivity.

Cited by 24 publications

References 55 publications

Mast Cells and Irritable Bowel Syndrome: From the Bench to the Bedside

Mast Cells and Irritable Bowel Syndrome: From the Bench to the Bedside

Four types of Bifidobacteria trigger autophagy response in intestinal epithelial cells

Mast Cell-dependent Mesenteric Afferent Activation by Mucosal Supernatant From Different Bowel Segments of Guinea Pigs With Post-infectious Irritable Bowel Syndrome

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