Synaptic plasticity in rat hippocampus associated with learning

Reempts, Jos Van; Dikova, M; Werbrouck, Leen; Clincke, G.; Borgers, M.

doi:10.1016/s0166-4328(05)80211-6

Cited by 36 publications

(32 citation statements)

References 27 publications

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“…4 -12 Similar changes can be induced during learning. [13][14][15][16] Another aspect of brain plasticity, first and most extensively demonstrated by Merzenich and coworkers, is that cortical representation areas, cortical maps, can be modified by sensory input, experience, and learning ( Figure 1), as well as in response to brain lesions. [17][18][19][20][21][22][23][24][25][26][27][28][29][30] The potential relevance for stroke rehabilitation of those data was proposed more than a decade ago.…”

Section: Current Concepts On Brain Plasticitymentioning

confidence: 95%

Brain Plasticity and Stroke Rehabilitation

Johansson

2000

Stroke

485

263

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Abstract-Neuronal connections and cortical maps are continuously remodeled by our experience. Knowledge of the potential capabilityof the brain to compensate for lesions is a prerequisite for optimal stroke rehabilitation strategies. Experimental focal cortical lesions induce changes in adjacent cortex and in the contralateral hemisphere. Neuroimaging studies in stroke patients indicate altered poststroke activation patterns, which suggest some functional reorganization.To what extent functional imaging data correspond to outcome data needs to be evaluated.

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Section: Current Concepts On Brain Plasticitymentioning

confidence: 95%

Brain Plasticity and Stroke Rehabilitation

Johansson

2000

Stroke

485

263

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“…Rapid alternations are bound to be reflected in a less specific remodeling of network activity [61]. More permanent change is reflected in, for example, augmented dendritic branching [62] and synaptogenesis [63], possibly provoked by specific gene induction [64, 65], and cumulates in an increase in the efficacy of synaptic transmission [66]. …”

Section: Use- and Training-dependent Plasticitymentioning

confidence: 99%

Pathophysiology of Stroke Rehabilitation: The Natural Course of Clinical Recovery, Use-Dependent Plasticity and Rehabilitative Outcome

2006

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Even though the disruption of motor activity and function caused by stroke is at times severe, recovery is often highly dynamic. Recuperation reflects the ability of the neuronal network to adapt. Next to an unmasking of latent network representations, other adaptive processes, such as excitatory metabolic stress, an imbalance in activating and inhibiting transmission, leading to salient hyperexcitability, or the consolidation of novel connections, prime the plastic capabilities of the system. Rehabilitative interventions may modulate mechanisms of neurofunctional plasticity and influence the natural course after stroke, both positively, but potentially also acting detrimentally. Though routine rehabilitative procedures are an integral part of stroke care, evidence as to their effectiveness remains equivocal. The present review describes the natural course of motor recovery, focusing on ischemic stroke, and discusses use- and training-dependent adaptive effects. It complements a prior article which highlighted the pathophysiology of plasticity. Though the interaction between rehabilitation and plasticity remains elusive, an attempt is made to clarify how and to what extent rehabilitative therapy shapes motor recovery.

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“…Transient forebrain ischemia or localized injections of ibotenic acid into the HPC correlates with memory deficits in rats (Volpe et al, 1992). Furthermore, notorious changes in dendritic spines of the hippocampal supragranular cell layer were observed associated to one-way active avoidance task training (Reempts et al, 1992) suggesting that synaptic plasticity is present during learning. It is known that there are many synaptic activesubstances in HPC (H6rtnagl et al, 1991;Sloviter and Nilaver, 1987) but limited information is available regarding these neuroactive compounds to specific physiological processes such as learning.…”

Section: Introductionmentioning

confidence: 97%

Hippocampal histamine receptors: Possible role on the mechanisms of memory in the rat, II

Alvarez

Banzán

1996

J. Neural Transmission

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In this paper it was studied the role of histamine and histamine receptors in the hippocampus of rats on an active avoidance response induced by an ultrasonic tone. The animals had to learn to walk through a swinging door into a safe compartment only after the conditioning ultrasonic tone was on in order to avoid an electric shock to their feet. Trained animals were implanted in the ventral hippocampus with microinjection cannulae and injected twice with 1 microliter of saline solution containing pyrilamine (PYR, H1-HA antagonist), ranitidine (RAN, H2-HA antagonist) or histamine. The histamine antagonists were applied in a dose of 65.5 nmol each while histamine was administered in a dose of 45 nmol. The two variables measured were the time in sec the rats take to present the conditioned avoidance response and the accumulated percentage of conditioned avoidance response (CAR). Results showed that histamine administration significantly increased the latency time to escape and decreased the % CAR. These effects were not blocked by the administration of RAN. However, administration of PYR completely counteracted the HA effects. Present findings confirm our previous findings about the inhibitory effect of histamine on the hippocampal retrieval mechanisms and give further support to the hypothesis that HA acts on the memory processes in the hippocampal formation, by activation of H1-histamine receptors.

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Synaptic plasticity in rat hippocampus associated with learning

Cited by 36 publications

References 27 publications

Brain Plasticity and Stroke Rehabilitation

Brain Plasticity and Stroke Rehabilitation

Pathophysiology of Stroke Rehabilitation: The Natural Course of Clinical Recovery, Use-Dependent Plasticity and Rehabilitative Outcome

Hippocampal histamine receptors: Possible role on the mechanisms of memory in the rat, II

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