Synaptic Plasticity: A Unifying Model to Address Some Persisting Questions

Michmizos, Dimitrios; Koutsouraki, Euphrosyni; Asprodini, Eftihia; Baloyannis, Stavros

doi:10.3109/00207454.2011.556283

Cited by 9 publications

(6 citation statements)

References 167 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This is in keeping with the finding of Guo et al that in AD there is regional atrophy in the cerebellum involving crus I and II. 26 Distal dendritic segments and dendritic spines, which are the most plastic components of the dendritic arborisation, 30 were prominently affected in Purkinje cells from AD brains. These changes may indicate an impairment of mechanisms underlying neuroplasticity in the cerebellar cortex AD.…”

Section: Discussionmentioning

confidence: 99%

Purkinje Cells Pathology in Alzheimer’s Disease

Mavroudis

Petridis

Kazis

et al. 2019

Am J Alzheimers Dis Other Demen

View full text Add to dashboard Cite

Alzheimer’s disease (AD) is one of the main causes of dementia in senium and presenium. It is clinically characterized by memory impairment, deterioration of intellectual faculties, and loss of professional skills. The cerebellum is a critical part in the distributed neural circuits participating not only in motor function but also in autonomic, limbic, and cognitive behaviors. In present study, we aim to investigate the morphological changes in the Purkinje cells in different cerebellar regions in AD and to correlate them with the underlying AD pathology. Purkinje cells exhibit significant morphometric alterations in AD and prominently in the anterior lobe which is related to higher cognitive functions. The present study gives new insights into the cerebellar pathology in AD and confirms that Purkinje cells pathology is a key finding in AD brains and that AD is characterized by regional-specific atrophy picked in the anterior cerebellar lobe.

show abstract

Section: Discussionmentioning

confidence: 99%

Purkinje Cells Pathology in Alzheimer’s Disease

Mavroudis

Petridis

Kazis

et al. 2019

Am J Alzheimers Dis Other Demen

View full text Add to dashboard Cite

show abstract

“…Although it generally takes several days to weeks for detectable changes to occur (Frenkel et al, 2006; Cooke and Bear, 2010; Kreile et al, 2011), a few rapid forms of plasticity induction, such as exposure to a photic tetanus, have also been reported (Teyler et al, 2005; Clapp et al, 2006). These plastic modifications rely largely on N -methyl- D- aspartate receptor (NMDAR) activity (Kleinschmidt et al, 1987; Malenka and Bear, 2004; Michmizos et al, 2011). …”

Section: Introductionmentioning

confidence: 99%

Flashing Lights Induce Prolonged Distortions in Visual Cortical Responses and Visual Perception

Minamisawa

Funayama

Matsumoto

et al. 2017

eNeuro

View full text Add to dashboard Cite

The primary sensory neocortex generates an internal representation of the environment, and its circuit reorganization is thought to lead to a modification of sensory perception. This reorganization occurs primarily through activity-dependent plasticity and has been well documented in animals during early developmental stages. Here, we describe a new method for the noninvasive induction of long-term plasticity in the mature brain: simple transient visual stimuli (i.e., flashing lights) can be used to induce prolonged modifications in visual cortical processing and visually driven behaviors. Our previous studies have shown that, in the primary visual cortex (V1) of mice, a flashing light stimulus evokes a long-delayed response that persists for seconds. When the mice were repetitively presented with drifting grating stimuli (conditioned stimuli) during the flash stimulus–evoked delayed response period, the V1 neurons exhibited a long-lasting decrease in responsiveness to the conditioned stimuli. The flash stimulus–induced underrepresentation of the grating motion was specific to the direction of the conditioned stimuli and was associated with a decrease in the animal’s ability to detect the motion of the drifting gratings. The neurophysiological and behavioral plasticity both persisted for at least several hours and required N-methyl-d-aspartate receptor activation in the visual cortex. We propose that flashing light stimuli can be used as an experimental tool to investigate the visual function and plasticity of neuronal representations and perception after a critical period of neocortical plasticity.

show abstract

“…Long-term plasticity includes long-term potentiation (LTP) and long-term depression (LTD) (Michmizos et al, 2011).…”

Section: Rim Is Involved In Neurotransmitter Releasementioning

confidence: 99%

The role of RIM in neurotransmitter release: promotion of synaptic vesicle docking, priming, and fusion

Fan

Tang

et al. 2023

Front. Neurosci.

View full text Add to dashboard Cite

There are many special sites at the end of a synapse called active zones (AZs). Synaptic vesicles (SVs) fuse with presynaptic membranes at these sites, and this fusion is an important step in neurotransmitter release. The cytomatrix in the active zone (CAZ) is made up of proteins such as the regulating synaptic membrane exocytosis protein (RIM), RIM-binding proteins (RIM-BPs), ELKS/CAST, Bassoon/Piccolo, Liprin-α, and Munc13-1. RIM is a scaffold protein that interacts with CAZ proteins and presynaptic functional components to affect the docking, priming, and fusion of SVs. RIM is believed to play an important role in regulating the release of neurotransmitters (NTs). In addition, abnormal expression of RIM has been detected in many diseases, such as retinal diseases, Asperger’s syndrome (AS), and degenerative scoliosis. Therefore, we believe that studying the molecular structure of RIM and its role in neurotransmitter release will help to clarify the molecular mechanism of neurotransmitter release and identify targets for the diagnosis and treatment of the aforementioned diseases.

show abstract

Synaptic Plasticity: A Unifying Model to Address Some Persisting Questions

Cited by 9 publications

References 167 publications

Purkinje Cells Pathology in Alzheimer’s Disease

Purkinje Cells Pathology in Alzheimer’s Disease

Flashing Lights Induce Prolonged Distortions in Visual Cortical Responses and Visual Perception

The role of RIM in neurotransmitter release: promotion of synaptic vesicle docking, priming, and fusion

Contact Info

Product

Resources

About