Synaptic innervation of sympathetic ganglion cells in the bullfrog

Weitsen, Howard A.; Weight, Forrest F.

doi:10.1016/0006-8993(77)90988-x

Cited by 34 publications

(21 citation statements)

References 31 publications

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“…Electrophysiological and morphological data support the idea that each B-cell is innervated by a single presynaptic B-fibre which descends in the ipsilateral paravertebral sympathetic chain (Nishi et al 1965;Weitsen & Weight, 1977;Baluk, 1986). Activation of these fibres in vitro produces a large, all-or-none EPSP which almost invariably exceeds threshold for AP generation (Smith, 1994).…”

Section: Characteristics Of B-sympathetic Pathwaysmentioning

confidence: 52%

In vivo activity of B‐ and C‐neurones in the paravertebral sympathetic ganglia of the bullfrog.

Ivanoff

Smith

1995

The Journal of Physiology

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1. Spontaneous, in vivo synaptic activity was recorded from 146 B‐cells and 60 C‐cells in the IXth and Xth paravertebral sympathetic ganglia of the urethane‐anaesthetized bullfrog. Sympathetic outflow to the blood vessels, which are innervated by C‐cells, is different from that received by targets in the skin, which are innervated by B‐cells. 2. B‐cells were divided into three groups: the first (61 cells) exhibited only action potentials (APs) at 0.01‐0.3 s‐1; the second (59 cells) exhibited APs and EPSPs and the third (26 cells) were silent. In addition to their usual suprathreshold input from the ipsilateral sympathetic chain, 53% of B‐cells received subthreshold input which probably arose from fibres in the contralateral chain. ‘Slow’ B‐cells exhibited less subthreshold activity and a slightly higher AP frequency than ‘fast’ B‐cells. All B‐cells are involved in a sympathetic reflex which is activated by tactile stimulation of the skin of the hindlimb. Activation of this reflex increased AP frequency without promoting long‐lasting depolarization. 3. Sixty‐seven per cent of C‐cells exhibited rhythmic bursting activity with or without small intraburst EPSPs. Bursts tended to correlate with electrocardiographic (ECG) activity. The remainder exhibited an irregular pattern of activity which was not correlated with ECG activity and which included one to three APs and EPSPs interspersed between the bursts. Activity of both types of C‐cell was inhibited following stimulation of the skin. 4. An average of twenty‐three B‐cells and twenty‐one C‐cells discharge simultaneously in vivo. This reflects branching of preganglionic fibres and results in synchrony of discharge in both postganglionic B‐ and C‐fibres.(ABSTRACT TRUNCATED AT 250 WORDS)

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Section: Characteristics Of B-sympathetic Pathwaysmentioning

confidence: 52%

In vivo activity of B‐ and C‐neurones in the paravertebral sympathetic ganglia of the bullfrog.

Ivanoff

Smith

1995

The Journal of Physiology

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“…Anatomical features of these ganglia have been described before (Uchizono & Ohsawa, 1973;Taxi, 1976;Weitsen & Weight, 1977). The major cell type is the ganglion cell (or principal cell).…”

Section: Synapses On Ganglion Cellsmentioning

confidence: 89%

Peptidergic transmission in sympathetic ganglia of the frog.

Jan¹,

Jan²

1982

The Journal of Physiology

369

226

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SUMMARY1. A slow synaptic potential recorded in neurones of sympathetic ganglia of bullfrog, the late slow e.p.s.p., is probably mediated by a peptide resembling luteinizing hormone-releasing hormone (LHRH), because (1) a LHRH-like peptide is contained in preganglionic nerve terminals and is released upon nerve stimulation, (2) application of LHRH to ganglion cells mimics the effects of the natural transmitter for the late slow e.p.s.p., and (3) the pharmacological properties of LHRH and the natural transmitter for the late slow e.p.s.p. are similar.2. Neurones in frog sympathetic ganglia are also depolarized by substance P. The

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“…Though no determinations of conduction velocity was made, we suppose that only the 'B' type cells were studied (cf. Nishi, Soeda & Koketsu, 1965;Tosaka, Chichubu & Libet, 1968;Weitsen & Weight, 1977), in view of their large size; and, on occasions when the preganglionic chain was stimulated , and personal observations), only the fast and slow excitatory post-synaptic potentials were observed without the intervening slow inhibitory post-synaptic potential characteristic of C cells (Tosaka et al 1968). However, experiments using a single micro-electrode voltage-clamp method (not included in the present description), in which a wider range of neurones were impaled, indicated that the M-current is not restricted to the largest cells, and J. P. Horn & J. Dodd (personal communication) have detected the presence of IM in identified C cells.…”

Section: Methodsmentioning

confidence: 94%