Synaptic Functions of Type-1 Cannabinoid Receptors in Inhibitory Circuits of the Anterior Piriform Cortex

Cholecystokinin neurotransmission in the central nervous system: Insights into its role in health and disease

“…CCK acting through CCKBR, also enhances the inhibition of glutamatergic neurons in the olfactory bulb 55 . Activation of cannabinoid receptor 1 (CB1R) in the anterior piriform cortex and hippocampus led to a decrease in inhibitory synaptic transmission 56,57 . The presynaptic CB1R, known to be highly expressed on CCK+ GABAergic neurons, 57–59 has the capability to suppress the co‐release of CCK and GABA, thereby modulating inhibitory long‐term potentiation (iLTP).…”

“… 55 Activation of cannabinoid receptor 1 (CB1R) in the anterior piriform cortex and hippocampus led to a decrease in inhibitory synaptic transmission. 56 , 57 The presynaptic CB1R, known to be highly expressed on CCK+ GABAergic neurons, 57 , 58 , 59 has the capability to suppress the co‐release of CCK and GABA, thereby modulating inhibitory long‐term potentiation (iLTP). Pre‐synaptically targeted interneurons (e.g., CCK), can be influenced by firing activity in the post‐synaptic neurons while dendritically targeted interneurons (e.g., somatostatin [SST]) are affected by the activity of glutamatergic neurons.…”

Cholecystokinin neurotransmission in the central nervous system: Insights into its role in health and disease

“…CCK acting through CCKBR, also enhances the inhibition of glutamatergic neurons in the olfactory bulb 55 . Activation of cannabinoid receptor 1 (CB1R) in the anterior piriform cortex and hippocampus led to a decrease in inhibitory synaptic transmission 56,57 . The presynaptic CB1R, known to be highly expressed on CCK+ GABAergic neurons, 57–59 has the capability to suppress the co‐release of CCK and GABA, thereby modulating inhibitory long‐term potentiation (iLTP).…”

“… 55 Activation of cannabinoid receptor 1 (CB1R) in the anterior piriform cortex and hippocampus led to a decrease in inhibitory synaptic transmission. 56 , 57 The presynaptic CB1R, known to be highly expressed on CCK+ GABAergic neurons, 57 , 58 , 59 has the capability to suppress the co‐release of CCK and GABA, thereby modulating inhibitory long‐term potentiation (iLTP). Pre‐synaptically targeted interneurons (e.g., CCK), can be influenced by firing activity in the post‐synaptic neurons while dendritically targeted interneurons (e.g., somatostatin [SST]) are affected by the activity of glutamatergic neurons.…”

Endogenous cannabinoids in the piriform cortex tune olfactory perception

“…In the aPC, CB1Rs are mainly expressed in the axon terminals of GABAergic neurons 31 that project to layers 2 and 3, where they control endocannabinoid-mediated plasticity 32 . CB1Rs are also strongly expressed in aPC-to-OB corticofugal axon terminals 33 .…”

“…CB1Rs are also strongly expressed in aPC-to-OB corticofugal axon terminals 33 . The physiological role of CB1Rs in piriform synaptic transmission and their impact on specific olfactory-guided behaviors has been explored previously 31,32,34,35 . However, little is known about the functions of endocannabinoid signaling at the network level.…”

“…Adult (2-5 month-old) male mice born in captivity were used in this study (i.e., only male mice were used in experimental study design and analysis). Mice carrying the "floxed" CB1 gene [CB1 f/f -CB1flox] were used for behavioral testing with cannula (a genotype consistent with our previous studies 31,32 ), and C57BL/6 J mice were used for in vivo electrophysiology and fiber photometry imaging. All behavioral experiments were performed during the light phase.…”

Cholecystokinin neurotransmission in the central nervous system: Insights into its role in health and disease

“…CCK acting through CCKBR, also enhances the inhibition of glutamatergic neurons in the olfactory bulb 55 . Activation of cannabinoid receptor 1 (CB1R) in the anterior piriform cortex and hippocampus led to a decrease in inhibitory synaptic transmission 56,57 . The presynaptic CB1R, known to be highly expressed on CCK+ GABAergic neurons, 57–59 has the capability to suppress the co‐release of CCK and GABA, thereby modulating inhibitory long‐term potentiation (iLTP).…”

“… 55 Activation of cannabinoid receptor 1 (CB1R) in the anterior piriform cortex and hippocampus led to a decrease in inhibitory synaptic transmission. 56 , 57 The presynaptic CB1R, known to be highly expressed on CCK+ GABAergic neurons, 57 , 58 , 59 has the capability to suppress the co‐release of CCK and GABA, thereby modulating inhibitory long‐term potentiation (iLTP). Pre‐synaptically targeted interneurons (e.g., CCK), can be influenced by firing activity in the post‐synaptic neurons while dendritically targeted interneurons (e.g., somatostatin [SST]) are affected by the activity of glutamatergic neurons.…”

Endogenous cannabinoids in the piriform cortex tune olfactory perception

“…In the aPC, CB1Rs are mainly expressed in the axon terminals of GABAergic neurons 31 that project to layers 2 and 3, where they control endocannabinoid-mediated plasticity 32 . CB1Rs are also strongly expressed in aPC-to-OB corticofugal axon terminals 33 .…”

“…CB1Rs are also strongly expressed in aPC-to-OB corticofugal axon terminals 33 . The physiological role of CB1Rs in piriform synaptic transmission and their impact on specific olfactory-guided behaviors has been explored previously 31,32,34,35 . However, little is known about the functions of endocannabinoid signaling at the network level.…”

“…Adult (2-5 month-old) male mice born in captivity were used in this study (i.e., only male mice were used in experimental study design and analysis). Mice carrying the "floxed" CB1 gene [CB1 f/f -CB1flox] were used for behavioral testing with cannula (a genotype consistent with our previous studies 31,32 ), and C57BL/6 J mice were used for in vivo electrophysiology and fiber photometry imaging. All behavioral experiments were performed during the light phase.…”

Cholecystokinin neurotransmission in the central nervous system: Insights into its role in health and disease

“…CCK acting through CCKBR, also enhances the inhibition of glutamatergic neurons in the olfactory bulb 55 . Activation of cannabinoid receptor 1 (CB1R) in the anterior piriform cortex and hippocampus led to a decrease in inhibitory synaptic transmission 56,57 . The presynaptic CB1R, known to be highly expressed on CCK+ GABAergic neurons, 57–59 has the capability to suppress the co‐release of CCK and GABA, thereby modulating inhibitory long‐term potentiation (iLTP).…”

“… 55 Activation of cannabinoid receptor 1 (CB1R) in the anterior piriform cortex and hippocampus led to a decrease in inhibitory synaptic transmission. 56 , 57 The presynaptic CB1R, known to be highly expressed on CCK+ GABAergic neurons, 57 , 58 , 59 has the capability to suppress the co‐release of CCK and GABA, thereby modulating inhibitory long‐term potentiation (iLTP). Pre‐synaptically targeted interneurons (e.g., CCK), can be influenced by firing activity in the post‐synaptic neurons while dendritically targeted interneurons (e.g., somatostatin [SST]) are affected by the activity of glutamatergic neurons.…”

Endogenous cannabinoids in the piriform cortex tune olfactory perception

“…In the aPC, CB1Rs are mainly expressed in the axon terminals of GABAergic neurons 31 that project to layers 2 and 3, where they control endocannabinoid-mediated plasticity 32 . CB1Rs are also strongly expressed in aPC-to-OB corticofugal axon terminals 33 .…”

“…CB1Rs are also strongly expressed in aPC-to-OB corticofugal axon terminals 33 . The physiological role of CB1Rs in piriform synaptic transmission and their impact on specific olfactory-guided behaviors has been explored previously 31,32,34,35 . However, little is known about the functions of endocannabinoid signaling at the network level.…”

“…Adult (2-5 month-old) male mice born in captivity were used in this study (i.e., only male mice were used in experimental study design and analysis). Mice carrying the "floxed" CB1 gene [CB1 f/f -CB1flox] were used for behavioral testing with cannula (a genotype consistent with our previous studies 31,32 ), and C57BL/6 J mice were used for in vivo electrophysiology and fiber photometry imaging. All behavioral experiments were performed during the light phase.…”