Synaptic Functions of Type-1 Cannabinoid Receptors in Inhibitory Circuits of the Anterior Piriform Cortex

Terral, Geoffrey; Varilh, Marjorie; Cannich, Astrid; Massa, Federico; Marsicano, Giovanni

doi:10.1016/j.neuroscience.2020.03.002

Cited by 5 publications

(5 citation statements)

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“…Adult (2-5 month-old) male mice born in captivity were used in this study (i.e., only male mice were used in experimental study design and analysis). Mice carrying the "floxed" CB1 gene [CB1 f/f -CB1flox] were used for behavioral testing with cannula (a genotype consistent with our previous studies 31,32 ), and C57BL/6 J mice were used for in vivo electrophysiology and fiber photometry imaging. All behavioral experiments were performed during the light phase.…”

Section: Animalsmentioning

confidence: 99%

“…In the aPC, CB1Rs are mainly expressed in the axon terminals of GABAergic neurons 31 that project to layers 2 and 3, where they control endocannabinoid-mediated plasticity 32 . CB1Rs are also strongly expressed in aPC-to-OB corticofugal axon terminals 33 .…”

mentioning

confidence: 99%

“…CB1Rs are also strongly expressed in aPC-to-OB corticofugal axon terminals 33 . The physiological role of CB1Rs in piriform synaptic transmission and their impact on specific olfactory-guided behaviors has been explored previously 31,32,34,35 . However, little is known about the functions of endocannabinoid signaling at the network level.…”

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confidence: 99%

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Endogenous cannabinoids in the piriform cortex tune olfactory perception

Terral,

Harrell,

Lepousez

et al. 2024

Nat Commun

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Sensory perception depends on interactions between external inputs transduced by peripheral sensory organs and internal network dynamics generated by central neuronal circuits. In the sensory cortex, desynchronized network states associate with high signal-to-noise ratio stimulus-evoked responses and heightened perception. Cannabinoid-type-1-receptors (CB1Rs) - which influence network coordination in the hippocampus - are present in anterior piriform cortex (aPC), a sensory paleocortex supporting olfactory perception. Yet, how CB1Rs shape aPC network activity and affect odor perception is unknown. Using pharmacological manipulations coupled with multi-electrode recordings or fiber photometry in the aPC of freely moving male mice, we show that systemic CB1R blockade as well as local drug infusion increases the amplitude of gamma oscillations in aPC, while simultaneously reducing the occurrence of synchronized population events involving aPC excitatory neurons. In animals exposed to odor sources, blockade of CB1Rs reduces correlation among aPC excitatory units and lowers behavioral olfactory detection thresholds. These results suggest that endogenous endocannabinoid signaling promotes synchronized population events and dampen gamma oscillations in the aPC which results in a reduced sensitivity to external sensory inputs.

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Section: Animalsmentioning

confidence: 99%

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confidence: 99%

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Endogenous cannabinoids in the piriform cortex tune olfactory perception

Terral,

Harrell,

Lepousez

et al. 2024

Nat Commun

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“…However, although relatively high levels of CB1 receptors were described in the 1990s in many olfactory brain areas of rodents [20][21][22][23], their olfactory-related functions only started to be studied during the last decade. Notably, the involvement of CB1 receptors in specific odor-related processes has been reported in specialized olfactory structures such as the olfactory epithelium (OE; [24][25][26][27]), the main olfactory bulb (MOB; [18,[28][29][30][31][32][33][34]), and the piriform cortex (PC; [35][36][37][38][39][40]), but also in other brain areas processing olfactory information [41][42][43][44]. For the sake of clarity in this review, we will focus on describing the role of the ECS, particularly CB1 receptor signaling, in specific main olfactory areas (i.e., OE, MOB, and PC).…”

Section: Role Of the Endocannabinoid System In Olfactory Circuitsmentioning

confidence: 99%

“…Despite the possible post-synaptic CB1 receptors' localization, or that endocannabinoids can modulate directly postsynaptic GABAergic receptors [55], further experiments will determine how CB1 receptor activation allows for controlling GABAergic conductance in the pPC. In the anterior PC (aPC), CB1 receptors were mainly described at GABAergic synapses, where they modulate inhibitory transmission and plasticity [37,40]. Moreover, depending on CB1 receptors in the aPC, the retrieval of appetitive, but not aversive, olfactory memory is associated with a modulation of local inhibitory transmission onto specific principal cells in the aPC [37].…”

Section: The Endocannabinoid System In the Piriform Cortexmentioning

confidence: 99%

Cannabinoid Control of Olfactory Processes: The Where Matters

Terral

Marsicano

Grandes

et al. 2020

Genes

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Olfaction has a direct influence on behavior and cognitive processes. There are different neuromodulatory systems in olfactory circuits that control the sensory information flowing through the rest of the brain. The presence of the cannabinoid type-1 (CB1) receptor, (the main cannabinoid receptor in the brain), has been shown for more than 20 years in different brain olfactory areas. However, only over the last decade have we started to know the specific cellular mechanisms that link cannabinoid signaling to olfactory processing and the control of behavior. In this review, we aim to summarize and discuss our current knowledge about the presence of CB1 receptors, and the function of the endocannabinoid system in the regulation of different olfactory brain circuits and related behaviors.

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Cholecystokinin neurotransmission in the central nervous system: Insights into its role in health and disease

Asim,

Wang,

Waris

et al. 2024

BioFactors

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Cholecystokinin (CCK) plays a key role in various brain functions, including both health and disease states. Despite the extensive research conducted on CCK, there remain several important questions regarding its specific role in the brain. As a result, the existing body of literature on the subject is complex and sometimes conflicting. The primary objective of this review article is to provide a comprehensive overview of recent advancements in understanding the central nervous system role of CCK, with a specific emphasis on elucidating CCK's mechanisms for neuroplasticity, exploring its interactions with other neurotransmitters, and discussing its significant involvement in neurological disorders. Studies demonstrate that CCK mediates both inhibitory long‐term potentiation (iLTP) and excitatory long‐term potentiation (eLTP) in the brain. Activation of the GPR173 receptor could facilitate iLTP, while the Cholecystokinin B receptor (CCKBR) facilitates eLTP. CCK receptors' expression on different neurons regulates activity, neurotransmitter release, and plasticity, emphasizing CCK's role in modulating brain function. Furthermore, CCK plays a pivotal role in modulating emotional states, Alzheimer's disease, addiction, schizophrenia, and epileptic conditions. Targeting CCK cell types and circuits holds promise as a therapeutic strategy for alleviating these brain disorders.

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Synaptic Functions of Type-1 Cannabinoid Receptors in Inhibitory Circuits of the Anterior Piriform Cortex

Cited by 5 publications

References 49 publications

Endogenous cannabinoids in the piriform cortex tune olfactory perception

Endogenous cannabinoids in the piriform cortex tune olfactory perception

Cannabinoid Control of Olfactory Processes: The Where Matters

Cholecystokinin neurotransmission in the central nervous system: Insights into its role in health and disease

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