Synaptic Dialogue: Substrate for Protein-Synthesis-Independent Long-Term Memory

Holahan, Matthew R.; Routtenberg, Aryeh

doi:10.1007/0-387-25443-9_24

Cited by 2 publications

(2 citation statements)

References 195 publications

(114 reference statements)

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“…How might the postsynaptic effects of NMDA receptor antagonists lead to expansion or retraction of presynaptic afferents? The blockade of either outgrowth or retraction may be due to a uncoupling of the dialogue between pre-and postsynaptic elements that regulates morphological adjustments (for reviews see Colley and Routtenberg, 1993;Holahan and Routtenberg, 2005). One hypothesized signaling pathway that links the pre-and postsynaptic elements is the postsynaptic NMDA receptor activation to presynaptic protein kinase C (PKC) phosphorylation via retrograde signaling mechanisms (Lynch et al, 1991;Schaechter and Benowitz, 1993;Luo and Vallano, 1995;Medina and Izquierdo, 1995;Fitzsimonds and Poo, 1998;Schmidt, 2004).…”

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confidence: 99%

Expansion and retraction of hippocampal mossy fibers during postweaning development: Strain‐specific effects of NMDA receptor blockade

2006

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ABSTRACT:We have recently discovered differences in the distribution of the mossy fiber terminal field (MFTF) between adult Long-Evans rats (LER) and Wistar rats(WR): the suprapyramidal MFTF extends into distal stratum oriens (dSO) in LER, but is nearly absent in WR (Holahan et al., 2006, Hippocampus 16:560-570). To our knowledge, there is no developmental evidence that sheds light on how this strain-dependent MFTF innervation in the adult is achieved. Accordingly, the present study examined the time course of MFTF development from postnatal days 0 to 40 and the effect of NMDA-receptor antagonist 3-(2-carboxypiperazin-4-yl) propyl-1-phosphonic acid (CPP) on this developmental organization. In both LER and WR, a MFTF projection to dSO was observed between P18 and P21. By P24, the dSO projection in WR was no longer detectable whereas in LER, the dSO projection seen on P21 remained. We suggest that in WR a retraction of the MFTF projection from dSO to stratum lucidum between P21 and P24 leads to its adult pattern. In WR, CPP administration enhanced the dSO projection, possibly by blocking the retraction process. In LER, CPP administration reduced the dSO projection. Thus, in each strain, NMDA receptor blockade effectively reversed the developmental course of MFTF pattern of innervation. The present results lend strong support to the view that NMDA receptor regulation of input-dependent processes during development is of critical importance in promoting the motility and target selection of presynaptic MF axons. This regulation extends later into development than had previously been thought. V V C 2006 Wiley-Liss, Inc.

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Expansion and retraction of hippocampal mossy fibers during postweaning development: Strain‐specific effects of NMDA receptor blockade

2006

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“…One suggestion might be that constitutive proteins, i.e. the protein repertoire, are under some conditions sufficient to assure LTD stabilization and, that posttranslational modifications (PTMs) are the determinant events [ 83 ]. In this regard, Auerbach and Bear [ 84 ] have shown that in case proteins are overexpressed, DHPG acts only via posttranslational mechanisms.…”

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confidence: 99%

Protein Synthesis Inhibitors Did Not Interfere with Long-Term Depression Induced either Electrically in Juvenile Rats or Chemically in Middle-Aged Rats

Abbas

2016

PLoS ONE

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In testing the hypothesis that long-term potentiation (LTP) maintenance depends on triggered protein synthesis, we found no effect of protein synthesis inhibitors (PSIs) on LTP stabilization. Similarly, some studies reported a lack of effect of PSIs on long-term depression (LTD); the lack of effect on LTD has been suggested to be resulting from the short time recordings. If this proposal were true, LTD might exhibit sensitivity to PSIs when the recording intervals were enough long. We firstly induced LTD by a standard protocol involving low frequency stimulation, which is suitable for eliciting NMDAR-LTD in CA1 area of hippocampal slices obtained from juvenile Sprague-Dawley rats. This LTD was persistent for intervals in range of 8–10 h. Treating slices with anisomycin, however, did not interfere with the magnitude and persistence of this form of LTD. The failure of anisomycin to block synaptic-LTD might be relied on the age of animal, the type of protein synthesis inhibitors and/or the inducing protocol. To verify whether those variables altogether were determinant, NMDA or DHPG was used to chemically elicit LTD recorded up to 10 h on hippocampal slices obtained from middle-aged rats. In either form of LTD, cycloheximide did not interfere with LTD stabilization. Furthermore, DHPG application did show an increase in the global protein synthesis as assayed by radiolabeled methodology indicating that though triggered protein synthesis can occur but not necessarily required for LTD expression. The findings confirm that stabilized LTD in either juvenile, or middle-aged rats can be independent of triggered protein synthesis. Although the processes responsible for the independence of LTD stabilization on the triggered protein synthesis are not yet defined, these findings raise the possibility that de novo protein synthesis is not universally necessary.

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Synaptic Dialogue: Substrate for Protein-Synthesis-Independent Long-Term Memory

Cited by 2 publications

References 195 publications

Expansion and retraction of hippocampal mossy fibers during postweaning development: Strain‐specific effects of NMDA receptor blockade

Expansion and retraction of hippocampal mossy fibers during postweaning development: Strain‐specific effects of NMDA receptor blockade

Protein Synthesis Inhibitors Did Not Interfere with Long-Term Depression Induced either Electrically in Juvenile Rats or Chemically in Middle-Aged Rats

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