Abstract:Synaptic cell adhesion molecules (SynCAMs) play an important role in the formation and maintenance of synapses and the regulation of synaptic plasticity. SynCAM3 is expressed in the synaptic cleft of the central nervous system (CNS) and is involved in the connection between axons and astrocytes. We hypothesized that SynCAM3 may be related to the astrocytic scar (glial scar, the most important factor of CNS injury treatment) through extracellular matrix (ECM) reconstitution. Thus, we investigated the influence … Show more
“…Song BG et al [ 10 ] hypothesized that synaptic cell adhesion molecules (SynCAMs) would facilitate the adhesion between axons and astrocytes and glial scar formation. Thus, a loss-of-function study of SynCAMs was designed using SynCAM3-knockout mice subjected to spinal cord injury.…”
“…Song BG et al [ 10 ] hypothesized that synaptic cell adhesion molecules (SynCAMs) would facilitate the adhesion between axons and astrocytes and glial scar formation. Thus, a loss-of-function study of SynCAMs was designed using SynCAM3-knockout mice subjected to spinal cord injury.…”
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