Synaptic architecture of a memory engram in the mouse hippocampus
Marco Uytiepo,
Yongchuan Zhu,
Eric Bushong
et al.
Abstract:Memory engrams are formed through experience-dependent remodeling of neural circuits, but their detailed architectures have remained unresolved. Using 3D electron microscopy, we performed nanoscale reconstructions of the hippocampal CA3-CA1 pathway following chemogenetic labeling of cellular ensembles with a remote history of correlated excitation during associative learning. Projection neurons involved in memory acquisition expanded their connectomes via multi-synaptic boutons without altering the numbers and… Show more
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