Synapse-associated protein 102 – a highly mobile MAGUK predominate in early synaptogenesis
Dominique Alexandra De Los Reyes,
Mohammad Yaman Karkoutly,
Yonghong Zhang
Abstract:Neurodevelopmental and neurodegenerative disorders are primarily characterized by serious structural and functional changes in excitatory glutamatergic synapses in the brain, resulting in many synaptic deficits and aberrant synapse loss. It is a big challenge to reverse these synaptic impairments as a treatment for neurological diseases in the field. Extensive research on glutamate receptors as therapeutic targets has been done but with little success shown in human trials. PSD-95-like MAGUK proteins perform a… Show more
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