Symptoms of Sleep Disordered Breathing and Risk of Cancer: A Prospective Cohort Study

Christensen, Anne Sofie Plum; Clark, Alice; Salo, Paula; Nymann, Peter; Lange, Peter; Prescott, Eva; Rod, Naja Hulvej

doi:10.5665/sleep.3030

Cited by 82 publications

(78 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…53 Two other studies, however, found no associations between OSA and cancer incidence. 54,55 In a populationbased retrospective cohort (n 5 8,783) in Copenhagen, Denmark, history of snoring and daytime sleepiness were not associated with cancer incidence 54 ; inferences from this study are limited by the lack of objective measures of OSA. 56 Another clinic-based study in Toronto, Ontario, Canada, that used 9,629 clinical records and covered about 8 years of follow-up (627 incident cancer cases), polysomnogram-assessed OSA was not associated with the incidence of cancer.…”

Section: What About Sf?mentioning

confidence: 71%

Putative Links Between Sleep Apnea and Cancer

Gozal

Farré

Nieto

2015

Chest

View full text Add to dashboard Cite

show abstract

Section: What About Sf?mentioning

confidence: 71%

Putative Links Between Sleep Apnea and Cancer

Gozal

Farré

Nieto

2015

Chest

View full text Add to dashboard Cite

show abstract

“…Two studies have explored whether sleep apnea is associated with cancer incidence in the same Spanish clinical cohort 83 and in a populationbased study in Denmark. 84 Th e results of these studies have not been entirely conclusive and reinforce the notion that additional epidemiologic studies are needed. 85 , 86 If the hypothesis that sleep apnea aff ects cancer risk or cancer prognosis is confi rmed, this could have profound implications for cancer prevention and/or cancer clinical management.…”

Section: Osa Oncogenesis and Cancer Riskmentioning

confidence: 88%

Intermittent Hypoxemia and OSA

Dewan

Nieto

Somers

2015

Chest

474

188

View full text Add to dashboard Cite

OSA is a common chronic disorder that is associated with signifi cant morbidity and mortality including cardiovascular, metabolic, and neurocognitive disease and increased cancer-related deaths. OSA is characterized by recurrent episodes of apneas and hypopneas associated with repetitive episodes of intermittent hypoxemia, intrathoracic pressure changes, and arousals.Intermittent hypoxemia (IH) is now being recognized as a potential major factor contributing to the pathogenesis of OSA-related comorbidities. OSA-related high-frequency IH is characterized by cycles of hypoxemia with reoxygenation that is distinctly diff erent than sustained low-frequency hypoxia and contributes to ischemia-reperfusion injury. Data from both animal and human studies support mechanistic links between IH and its adverse impact at the tissue level. IH promotes oxidative stress by increased production of reactive oxygen species and angiogenesis, increased sympathetic activation with BP elevation, and systemic and vascular infl ammation with endothelial dysfunction that contributes to diverse multiorgan chronic morbidity and mortality aff ecting cardiovascular disease, metabolic dysfunction, cognitive decline, and progression of cancer. Data from observational studies in large population groups also support the role for hypoxia in the pathogenesis of OSA comorbidity. Treatment with CPAP to reverse OSA-related symptoms and comorbidities has been shown to provide variable benefi t in some but not all patient groups. Early treatment with CPAP makes intuitive sense to promote maximal functional recovery and minimize residual injury. More studies are needed to determine the interacting eff ects of IH and obesity, diff erential eff ects of both short-term and longterm hypoxemia, and the eff ect of CPAP treatment.CHEST 2015; 147 ( 1 ): 266 -274 ABBREVIATIONS : AF 5 atrial fi brillation ; AHI 5 apnea-hypopnea index ; HIF 5 hypoxia-inducible factor ; IH 5 intermittent hypoxemia ; NADPH 5 reduced nicotinamide adenine dinucleotide phosphate ; NO 5 nitric oxide ; ROS 5 reactive oxygen species ; Sp o 2 5 pulse oximetry blood oxygen saturation ; VEGF 5 vascular endothelial growth factor[ Contemporary Reviews in Sleep Medicine ]

show abstract

“…Long-term consequences of OSA include an increased risk of hypertension and cardiovascular disease, particularly stroke and heart failure, and impaired quality of life (89,90). Work suggests there may also be a link between sleep apnea and diabetes, depression, as well as cancer (91)(92)(93). Obesity is a common risk factor (94), with 60-90% of patients with OSA presenting with a body mass index greater than 30 kg/m 2 (95).…”

Section: Adult Obstructive Sleep Apneamentioning

confidence: 99%

An Official American Thoracic Society Statement: The Importance of Healthy Sleep. Recommendations and Future Priorities

Mukherjee

Patel

Kales

et al. 2015

Am J Respir Crit Care Med

221

153

View full text Add to dashboard Cite

Rationale: Despite substantial public interest, few recommendations on the promotion of good sleep health exist to educate health care providers and the general public on the importance of sleep for overall health.Objectives: The aim of this American Thoracic Society (ATS) statement is to provide a review of the current scientific literature to assist health care providers, especially pulmonologists and sleep physicians, in making recommendations to patients and the general public about the importance of achieving good quality and adequate quantity of sleep.Methods: ATS members were invited, based on their expertise in sleep medicine, and their conclusions were based on both empirical evidence identified after comprehensive literature review and clinical experience.Main Results: We focus on sleep health in both children and adults, including the impact of occupation on sleep, the public health implications of drowsy driving, and the common sleep disorders of obstructive sleep apnea and insomnia. This ATS statement also delineates gaps in research and knowledge that should be addressed and lead to new focused research priorities to advance knowledge in sleep and sleep health.Conclusions: Good quality and quantity of sleep are essential for good health and overall quality of life; therefore a strong recommendation was made for the implementation of public education programs on the importance of sleep health.

show abstract

Symptoms of Sleep Disordered Breathing and Risk of Cancer: A Prospective Cohort Study

Abstract: We found very limited evidence of relationship between symptoms of sleep disordered breathing and incidence of cancer.

Cited by 82 publications

References 34 publications

Putative Links Between Sleep Apnea and Cancer

Putative Links Between Sleep Apnea and Cancer

Intermittent Hypoxemia and OSA

An Official American Thoracic Society Statement: The Importance of Healthy Sleep. Recommendations and Future Priorities

Contact Info

Product

Resources

About