Symptoms of pediatric feeding disorders among individuals with 3q29 deletion syndrome

Abstract

Objective: To evaluate symptoms of pediatric feeding disorders in a sample of individuals with 3q29 Deletion Syndrome. Previous research has found that individuals with 3q29 deletion syndrome (3q29Del) may experience elevated feeding concerns in early childhood; however, the specificity of these feeding concerns in this pediatric population is not well understood. Methods: We compared individuals with 3q29Del (n = 60) to matched controls (n = 59) using an 11-item survey that assessed commonly reported symptoms associated with pediatric feeding disorders. An exploratory analysis also examined individuals with 3q29Del with and without a comorbid autism spectrum disorder (ASD) diagnosis. Results: Caregivers of 3q29Del cases reported higher incidences of feeding concerns on all 11 items included in the survey. This included statistically significant differences in food refusal behaviors, rejection of one or more food group, and a history of failure to thrive. Parents of children with comorbid autism were more likely to report concerns regarding rejection of one or more food group compared to children with 3q29Del without autism. Conclusions: Results suggest individuals with 3q29Del experience increased symptoms of pediatric feeding disorders. Future research should include a more thorough multidisciplinary evaluation to further document the severity and identify optimal remediation strategies.

Musculoskeletal phenotypes in 3q29 deletion syndrome

“…Individuals with 3q29 deletion syndrome should also receive physical therapy assessments, including the six-minute walk test (Andersen et al, 2016;Kuettel et al, 2022), to help guide clinical care. Additionally, the significantly elevated incidence of bone fracture in our study sample suggests that the 3q29 deletion may have an adverse impact on bone mineral density, which may be compounded by documented feeding challenges within the 3q29del population (Wawrzonek et al, 2022). Reduced bone mineral density has also been identified in other copy number variant disorders, including 22q11.2 deletion syndrome and Williams syndrome (Cherniske et al, 2004;Copes et al, 2016;Ficcadenti et al, 2015;Homans et al, 2018;Stagi et al, 2010).…”