Symptoms of anxiety in depression: assessment of item performance of the Hamilton Anxiety Rating Scale in patients with depression

Vaccarino, Anthony L.; Evans, Ken; Sills, Terrence; Kalali, Amir H

doi:10.1002/da.20435

Cited by 49 publications

(36 citation statements)

References 32 publications

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“…In addition, especially the somatic symptoms of the HARS could be indicative of higher levels of depression severity [Vaccarino et al 2008]. Because of the high correlation between the HARS and the HDRS we could not assess whether the association of anxiety and its dimensions with cardiac prognosis is independent from depression which is an important limitation of this study.…”

Section: Discussionmentioning

confidence: 92%

Symptom dimensions of anxiety following myocardial infarction: Associations with depressive symptoms and prognosis.

et al. 2014

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ObjectiveDifferential associations of symptom dimensions with prognosis in myocardial infarction (MI) patients have been shown for depression, but no studies have focused on anxiety dimensions.The aim of this study was to assess the association between somatic and psychological symptoms of anxiety following acute MI with adverse prognosis and to assess the overlap between anxiety and depression dimensions. MethodsPatients (n=418) were assessed on demographic and clinical variables. The Hamilton Anxiety and Depression Rating Scales were used to measure anxiety and depression 2 months post-MI.Mean follow-up period was 3.8 years and the endpoint consisted of all-cause mortality and recurrent MI. ResultsAfter adjustment for demographic and clinical variables, somatic anxiety was significantly associated with recurrent MI and mortality (HR: 1.32; 95% CI: 1.03-1.69; p=0.03), while a trend was shown for an association between psychological anxiety and outcome (HR: 1.29; 95% CI: 0.99-1.67; p=0.06). The total anxiety score of the HARS was the strongest predictor of recurrent MI and mortality (HR: 1.38; 95% CI: 1.07-1.78; p=0.02). The HARS and the HDRS were highly correlated (r=0.86; p<0.01). Dimensions consisting of psychological distress (HR: 1.29; 95% CI:1.02-1.63; p=0.03) and cardiopulmonary/autonomic symptoms (HR: 1.36; 95% CI: 1.06-1.75; p=0.02) also predicted outcome in adjusted analyses. ConclusionsAnxiety was associated with adverse prognosis in MI patients with significant associations for somatic anxiety and total anxiety. When combining anxiety and depression items, psychological distress and cardiopulmonary/autonomic symptoms predicted recurrent MI and mortality. Future 4 research might better focus on dimensions of anxiety and depression simultaneously in MI patients.

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Section: Discussionmentioning

confidence: 92%

Symptom dimensions of anxiety following myocardial infarction: Associations with depressive symptoms and prognosis.

et al. 2014

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“…These women were interviewed between 24 and 28 weeks of gestation for psychiatric diagnoses using the Structured Clinical Interview for the DSM‐IV‐R (SCID; Williams et al, 1992). Mood and anxiety symptom severity was obtained at 28 and 34 weeks of gestation using the Inventory of Depressive Symptomatology (IDS‐C; Trivedi et al, 2004), and the Hamilton Anxiety Rating Scale (HAM‐A; Vaccarino, Evans, Sills, & Kalali, 2008). A study investigator, not involved in the structured interviews, conducted a chart review at the time of delivery/placental sample collection for this subset of women in the same manner that the other participant information was collected.…”

Section: Methodsmentioning

confidence: 99%

Maternal depression and anxiety are associated with altered gene expression in the human placenta without modification by antidepressant use: Implications for fetal programming

Ponder

Salisbury

McGonnigal

et al. 2011

Developmental Psychobiology

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Objective We sought to determine if maternal depression, anxiety, and/or treatment with selective serotonin reuptake inhibitors (SSRIs) affect placental human serotonin transporter (SLC6A4), norepinephrine transporter (SLC6A2), and 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) gene expression. Methods Relative mRNA expression was compared among placental samples (n=164) from healthy women, women with untreated depression and/or anxiety symptoms during pregnancy, and women who used SSRIs. Results SLC6A4 expression was significantly increased in placentas from women with untreated mood disorders and from women treated with SSRIs, compared to controls. SLC6A2 and 11β-HSD2 expression was increased in non-control groups, though the differences were not significant. SLC6A4, SLC6A2, and 11β-HSD2 expression levels were positively correlated. Conclusions The finding that maternal depression/anxiety affects gene expression of placental SLC6A4 suggests a possible mechanism for the effect(s) of maternal mood on fetal neurodevelopmental programming. SSRI treatment does not further alter the elevated SLC6A4 expression levels observed with exposure to maternal depression or anxiety.

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“…Somatic symptoms co-occur frequently with anxiety and depression (5) and that they tend to be stable over time (6). Chronic somatic symptoms in childhood significantly predicts psychopathology in adulthood (7).…”

Section: Introductionmentioning

confidence: 99%

Somatic Symptoms among Children and Adolescents in Poland: A Confirmatory Factor Analytic Study of the Children Somatization Inventory

Essau

Olaya

Bokszczanin

et al. 2013

Front. Public Health

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The aim of the present study was to examine the factor structure and psychometric properties of the short version of the Children’s Somatization Inventory (CSI-24) in Poland. The CSI-24 is a self-report questionnaire designed to assess somatic symptoms in children and adolescents. A total of 733 children and adolescents, aged 12–17 years, participated in this research. The participants for this study were recruited from urban and suburban schools of Opole province in South Western Poland. In addition to the CSI-24, all participants completed the Spence Children’s Anxiety Scale (SCAS) and the Strength and Difficulties Questionnaire (SDQ). The correlated four-factor model that included four-correlated dimensions (pain/weakness, gastrointestinal problems, cardiovascular symptoms, and pseudoneurological problems) showed a better fit compared to the single-factor model. The Cronbach’s Alpha for the CSI-24 was 0.91. Somatic symptoms correlated significantly highly with the SCAS total scores and the SDQ emotional subscale, suggesting good construct validity. Somatic symptoms had low correlation with the SDQ behavioral problems symptoms, suggesting adequate discriminant validity. The CSI-24 reliably measured somatic symptoms in children and adolescents in Poland.

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Symptoms of anxiety in depression: assessment of item performance of the Hamilton Anxiety Rating Scale in patients with depression

Abstract: These results demonstrate anxiety as a core feature of depression, and the relationship between anxiety-related symptoms and depression should be considered in the assessment of depression and evaluation of treatment strategies and outcome.

Cited by 49 publications

References 32 publications

Symptom dimensions of anxiety following myocardial infarction: Associations with depressive symptoms and prognosis.

Symptom dimensions of anxiety following myocardial infarction: Associations with depressive symptoms and prognosis.

Maternal depression and anxiety are associated with altered gene expression in the human placenta without modification by antidepressant use: Implications for fetal programming

Somatic Symptoms among Children and Adolescents in Poland: A Confirmatory Factor Analytic Study of the Children Somatization Inventory

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