Symptoms of anxiety and depression during pregnancy and their association with low birth weight in Chinese women: a nested case control study

Yang, Shuai; Yang, Rong; Liang, Shengwen; Wang, Jing; Weaver, Nancy L.; Hu, Ke; Hu, Ronghua; Trevathan, Edwin; Huang, Zhen; Zhang, Yiming; Yin, Ting; Chang, Jen Jen; Zhao, Jing; Shen, Longjiao; Dong, Guang‐Hui; Zheng, Tongzhang; Xu, Shunqing; Qian, Zhengmin; Zhang, Bin

doi:10.1007/s00737-016-0697-2

Cited by 28 publications

(25 citation statements)

References 31 publications

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“…Relevant studies from China and with large sample size are limited. Yang's case-control study in Wuhan found that antenatal depression or anxiety was not significantly associated with LBW, but individuals with antenatal depression combined with anxiety were at a higher risk of LBW [24]. However, the self-designed questionnaires, rather than a typical screening scale were used in the study for measuring depressive states.…”

Section: Discussionmentioning

confidence: 99%

The association between symptoms of depression during pregnancy and low birth weight: a prospective study

Gao

Dai

et al. 2020

BMC Pregnancy Childbirth

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Background: Most studies have showed that maternal depression is associated with pregnancy complications. However, there were limited evidences in Chinese population. We examined the associations of antenatal depression symptoms with pregnancy outcomes, especially for low birth weight. Methods: A total of 1377 singleton pregnant women were recruited from Nanshan Maternity & Child Healthcare Hospital of Shenzhen in this prospective cohort study. Depression symptoms were assessed by the Edinburgh postnatal depression scale (EPDS) questionnaire in the second trimester of gestation; cut-points for the indication of antenatal depression were ≧12 scores in this study. Socio-demographic data, life-style and pregnancy outcomes were collected through Shenzhen Maternity & Child Healthcare database. The risks of adverse outcomes in pregnant women with antenatal depression were determined by multivariate logistic regression and represented as odds ratio(OR) and 95% confidence interval (CI). Results: Of the 1377 subjects, the prevalence of antenatal depression was 19.1%. The EPDS scores were 13.8 ± 2.0 and 6.5 ± 2.9 (P < 0.001) in subjects with and without antenatal depression, respectively. After adjustment for maternal age, education, parity, pre-pregnancy body mass index (BMI), residential area, fetal gender, an EPDS score ≥ 12 (versus. < 12) was associated with an increased risk for low birth weight (odds ratio: 2.05, 95% CI: 1.12-4.64), but not for preterm birth, large for gestational age, small for gestational age or macrosomia. Conclusion: Pregnant women presenting antenatal depressive symptoms are at elevated risk of low birth weight. Mental health problems of pregnancy should be addressed for the prevention of low birth weight.

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Section: Discussionmentioning

confidence: 99%

The association between symptoms of depression during pregnancy and low birth weight: a prospective study

Gao

Dai

et al. 2020

BMC Pregnancy Childbirth

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“…Third, we did not investigate the effect of maternal depressive symptoms, which often occur in comorbidity with anxious symptomatology (Garfield et al, 2014;O' Hara and Wisner, 2014;Yang et al, 2017), and we did not assess the quality of motherchild relationships that, in the case of anxiety, may interfere with caregiving practices (Beebe et al, 2011;Pisoni et al, 2018), representing a risk factor for infant development. Further studies should also include these factors.…”

Section: Discussionmentioning

confidence: 99%

Developmental Dimensions in Preterm Infants During the 1st Year of Life: The Influence of Severity of Prematurity and Maternal Generalized Anxiety

et al. 2020

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Background: The literature has recognized premature birth as a risk factor for infant development and maternal anxiety. This study investigated the impact of the severity of birth weight, as well as of maternal anxiety at 3 months of infants' corrected age, on infants' outcomes during the 1st year postpartum. Moreover, it described the longitudinal trajectories of developmental outcomes, additionally exploring the impact of anxiety. Methods: The study compared 147 mothers and their 147 newborns, differentiated in 25 Extremely Low Birth Weight (ELBW), 41 Very Low Birth Weight (VLBW), and 81 Full-Term (FT) infants. At 3, 9, and 12 months (corrected age in the case of preterm infants) the level of infants' development was investigated according to the 5 quotients (Locomotor, Personal and Social, Hearing and Language, Eye-hand Coordination and Performance) of the Griffiths Mental Development Scales (GMDS-R). During the assessment of 3 months, mothers fulfilled Penn State Worry Questionnaire (PSWQ) to evaluate the presence of generalized anxiety. Results: Among the 5 GMDS-R quotients, significant effect of severity of birth weight emerged only for Performance quotient: preterm infants (ELBW at 3 months; VLBW at 12 months) showed lower scores than FT ones. Moreover, this quotient decreased from 3 to 9 and to 12 months for VLBW and FT infants, while it was stable for ELBW ones. A significant interaction between severity of birth weight and maternal anxiety emerged for Hearing and Language and Locomotor quotients. In the first case, scores for ELBW infants, independently from maternal anxiety, decreased from 9 to 12 months. The same results emerged for VLBW infants, in the case of non-anxious mothers. Regarding Locomotor quotient, mean scores decreased from 3 to 9 and to 12 months for all groups in the case of non-anxious mothers. Conversely, when mothers were anxious, this decrease emerged only for VLBW infants. Lastly, ELBW, VLBW and FT showed difference in the growth and slope of the trajectories of different quotients.

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Section: Discussionmentioning

confidence: 99%

The association between symptoms of depression during pregnancy and low birth weight:a prospective study

Gao

Dai³

et al. 2020

Preprint

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Objectives Most studies have showed that maternal depression is associated with pregnancy complications. However, there were limited evidences in Chinese population. We examined the associations of the antenatal depression symptoms with pregnancy outcomes, especially for low birth weight. Methods A total of 1377 singleton pregnant women were recruited from Nanshan Maternity & Child Healthcare Hospital of Shenzhen in this prospective cohort study. Depression symptoms were assessed by the Edinburgh postnatal depression scale (EPDS) questionnaire in the second trimester of gestation; cut-points for the indication of antenatal depression were ≥12 scores in this study. Sociodemographic data, life-style and pregnancy outcomes were collected through Shenzhen Maternity & Child Healthcare database. The risks of adverse outcomes in patients with depression were determined by multivariate logistic regression and represented as odds ratios (ORs) and 95% confidence intervals (CIs). Results Of the 1377 subjects, the prevalence of antenatal depression was 19.1%. The EPDS scores were 13.8±2.0 and 6.5±2.9 ( P <0.001) in subjects with and without antenatal depression, respectively. After adjustment for maternal age, education, parity, pre-pregnancy body mass index (BMI), residential area, fetal gender, an EPDS score≥12 (versus. <12) was associated with an increased risk for low birth weight (odds ratio: 2.05, 95% CI: 1.12-4.64), but not for preterm birth, large for gestational age, small for gestational age and macrosomia. Conclusion Pregnant women presenting antenatal depressive symptoms are at elevated risk of low birth weight. Mental health problems of pregnancy should be addressed for the prevention of low birth weight.

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Symptoms of anxiety and depression during pregnancy and their association with low birth weight in Chinese women: a nested case control study

Cited by 28 publications

References 31 publications

The association between symptoms of depression during pregnancy and low birth weight: a prospective study

The association between symptoms of depression during pregnancy and low birth weight: a prospective study

Developmental Dimensions in Preterm Infants During the 1st Year of Life: The Influence of Severity of Prematurity and Maternal Generalized Anxiety

The association between symptoms of depression during pregnancy and low birth weight:a prospective study

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