Symptoms of anxiety and depression are frequent in patients with acute hepatitis C and are not associated with disease severity

Deterding, Katja; Grüner, N.; Buggisch, Peter; Galle, PR; Spengler, Ulrich; Hinrichsen, Holger; Berg, Thomas; Potthoff, Andrej; Grohennig, A; Koch, Armin; Diepolder, Helmut M.; Lüth, Stefan; Feyerabend, Sandra; Jung, Minyoung; Rogalska-Taranta, Magdalena; Schlaphoff,; Cornberg, Markus; Manns, MP; Wedemeyer, Heiner

doi:10.1097/meg.0000000000000517

Cited by 8 publications

(8 citation statements)

References 18 publications

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“…Limitations of this study include the limitations of the instrument to measure anxiety or depression. While the HADS has been used to assess the prevalence of anxiety and depression in clinical trials of many diseases, [34][35][36][37] including moderate-to-severe plaque psoriasis, 29,[38][39][40][41] some studies have proposed that HADS is best suited for screening rather than assessment of severity of anxiety and depression over time. [42][43][44] In addition, the optimal HADS score cut-off to define clinically important improvement in symptoms of anxiety or depression remains undertermined.…”

Section: Discussionmentioning

confidence: 99%

Anxiety and depression in patients with moderate‐to‐severe psoriasis and comparison of change from baseline after treatment with guselkumab vs. adalimumab: results from the Phase 3 VOYAGE 2 study

Gordon

Armstrong

Han

et al. 2018

Acad Dermatol Venereol

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Section: Discussionmentioning

confidence: 99%

Anxiety and depression in patients with moderate‐to‐severe psoriasis and comparison of change from baseline after treatment with guselkumab vs. adalimumab: results from the Phase 3 VOYAGE 2 study

Gordon

Armstrong

Han

et al. 2018

Acad Dermatol Venereol

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“…Forced expiratory volume has been used as index of severity of cystic fibrosis. Aminotransferase and bilirubin levels have been used to assess the severity of hepatitis.…”

Section: Severity Of Physical Illnessesmentioning

confidence: 99%

The severity of psychiatric disorders

2018

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The issue of the severity of psychiatric disorders has great clinical importance. For example, severity influences decisions about level of care, and affects decisions to seek government assistance due to psychiatric disability. Controversy exists as to the efficacy of antidepressants across the spectrum of depression severity, and whether patients with severe depression should be preferentially treated with medication rather than psychotherapy. Measures of severity are used to evaluate outcome in treatment studies and may be used as meaningful endpoints in clinical practice. But, what does it mean to say that someone has a severe illness? Does severity refer to the number of symptoms a patient is experiencing? To the intensity of the symptoms? To symptom frequency or persistence? To the impact of symptoms on functioning or on quality of life? To the likelihood of the illness resulting in permanent disability or death? Putting aside the issue of how severity should be operationalized, another consideration is whether severity should be conceptualized similarly for all illnesses or be disorder specific. In this paper, we examine how severity is characterized in research and contemporary psychiatric diagnostic systems, with a special focus on depression and personality disorders. Our review shows that the DSM-5 has defined the severity of various disorders in different ways, and that researchers have adopted a myriad of ways of defining severity for both depression and personality disorders, although the severity of the former was predominantly defined according to scores on symptom rating scales, whereas the severity of the latter was often linked with impairments in functioning. Because the functional impact of symptom-defined disorders depends on factors extrinsic to those disorders, such as self-efficacy, resilience, coping ability, social support, cultural and social expectations, as well as the responsibilities related to one's primary role function and the availability of others to assume those responsibilities, we argue that the severity of such disorders should be defined independently from functional impairment.

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“…Women with NAFLD are more likely to develop anxiety and depression than men and had a higher incidence of steatosis ( Choi et al, 2021 ). The study by Zhang et al (2020) found that the feeling of being discriminated against in daily life was the main influencing factor for anxiety and depression in patients with acute hepatitis B. Anxiety and depression were common in acute hepatitis C infection, but it was not related to the severity of the disease, the method of infection, or the rate at which patients were lost to follow-up ( Deterding et al, 2016 ). Even for high-risk patients with severe mental disorders, direct antiviral therapy had no effect on anxiety or depression during or after treatment for chronic hepatitis C infection ( Gallach et al, 2018 ).…”

Section: Discussionmentioning

confidence: 99%

Anxiety and Its Influencing Factors in Patients With Drug-Induced Liver Injury

Liu

Guo

et al. 2022

Front. Psychol.

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ObjectiveThis study aims to investigate anxiety and its influencing factors in patients with drug-induced liver injury (DILI).Materials and MethodsNinety-four patients with DILI were enrolled and evaluated with a self-rating anxiety scale (SAS). According to the anxiety score, they were divided into four groups: the non-anxiety, mild anxiety, moderate anxiety, or severe anxiety groups, and the scores were analyzed based on demographic and biochemical indicators.ResultsOf the 94 patients with DILI, 63 did not have anxiety and 31 had anxiety (32.9%), of which 27 had mild, 3 had moderate, and 1 had severe anxiety. There were no statistically significant differences in gender, age, occupation, and level of education between the groups (F = 1.42, H = 2.361, H = 6.751, H = 1.796, and P > 0.05); anxiety score and degree of anxiety between the types of drugs that led to the liver injury (H = 0.812, H = 1.712, and P > 0.05); anxiety score between the different degrees of liver injury (H = 2.836, H = 4.957, P > 0.05); or length of hospital stay or prognosis between the degrees of anxiety (F = 1.487, H = 0.761, P > 0.05). However, there were statistically significant differences in the degree of anxiety between different degree and types of liver injury (H = 7.981, H = 8.208, P < 0.05).ConclusionPatients with DILI may have anxiety, especially mild anxiety. The occurrence of anxiety in patients with DILI is not related to gender, age, occupation, or level of education but may be related to the degree and type of liver injury. Anxiety has no impact on the length of stay in hospital or the prognosis of the DILI. These findings may contribute to the development of management strategies for patients with DILI.

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Symptoms of anxiety and depression are frequent in patients with acute hepatitis C and are not associated with disease severity

Abstract: HADS data in acute HCV infection indicate that anxiety and depression do not correlate with severity of the disease, mode of acquisition, lost to follow-up and sustained virological response rates.

Cited by 8 publications

References 18 publications

Anxiety and depression in patients with moderate‐to‐severe psoriasis and comparison of change from baseline after treatment with guselkumab vs. adalimumab: results from the Phase 3 VOYAGE 2 study

Anxiety and depression in patients with moderate‐to‐severe psoriasis and comparison of change from baseline after treatment with guselkumab vs. adalimumab: results from the Phase 3 VOYAGE 2 study

The severity of psychiatric disorders

Anxiety and Its Influencing Factors in Patients With Drug-Induced Liver Injury

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