Symptoms and Symptom Management in Survivorship Patients

Klein, Gilles; Jodocy, Daniel

doi:10.1007/978-3-030-78648-9_10

Cited by 3 publications

(2 citation statements)

References 252 publications

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“…Pregabalin is an attractive adjuvant for perioperative analgesia in this regard as it can be taken on an empty stomach, does not lead to gastrointestinal bleeding, and is generally well tolerated [16] . The efficacy of pregabalin in treating acute postsurgical pain has been demonstrated in numerous studies [17,18,19] .…”

Section: Discussionmentioning

confidence: 99%

The Effect of Pregabalin on Postoperative Pain in Patients Undergoing Abdominal Surgery under General Anesthesia

AHMED M.A.I. GAMAL ELDIN, M.Sc.;

2023

The Medical Journal of Cairo University

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Background: Acute postoperative pain and side effects can be serious problems, due to either insufficient or excessive treatment. If analgesic treatment is begun after a painful stimulus, treating postoperative pain can be challenging because of the possibility of peripheral hypersensitivity and central nervous system hyperexcitability. Pre-emptive analgesia focuses on reducing postoperative opioid consumption and pain levels, decreasing the incidence of adverse events and improving patient satisfaction. Several pre-emptive analgesic regimens have been tried in the perioperative period, including opioids, nonsteroidal anti-inflammatory drugs, and so on. Aim of Study:To evaluate the effects of oral pregabalin, before abdominal surgery, on postoperative pain intensity and analgesic requirements (primary outcome), and the incidence of post-operative nausea and vomiting (secondary outcome).Patients and Methods: This randomized controlled trial was conducted on 60 adult healthy patients aged 21-50 years of both sex, ASA physical status I and II undergoing elective abdominal surgery (open or laparoscopic). Patients were equally randomized to: Group A: Received pregabalin 300mg/12hrs 24 hrs before surgery. Group B: Did not receive pregabalin.Results: Time of first analgesic requirement was significantly delayed in group A compared to group B ( p-value <0.001). Total pethidine consumption was significantly lower in group A compared to group B (p-value <0.001). Incidence of PONV was 5 (16.67%) patients in group A and 13 (43.33%) in group B. Incidence of dizziness was 20 (66.67%) patients in group A and 4 (13.33%) in group B. Incidence of PONV was significantly lower in group A compared to group B ( p -value=0.024). Incidence of dizziness was significantly higher in group A compared to group B (p-value <0.001). Respiratory depression and hypotension were insignificantly different between both groups. Conclusion:Preoperative administration of 300mg/12hrs 24hrs of pregabalin resulted in a significant reduction pain score, intraoperative fentanyl consumption, total pethidine consumption and incidence of PONV following elective abdominal surgery but with higher incidence of dizziness.

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Section: Discussionmentioning

confidence: 99%

The Effect of Pregabalin on Postoperative Pain in Patients Undergoing Abdominal Surgery under General Anesthesia

AHMED M.A.I. GAMAL ELDIN, M.Sc.;

2023

The Medical Journal of Cairo University

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“…It is commonly perceived as a life-threatening and potentially traumatic illness ( 3 ). Patients who received cancer diagnosis and undergo its treatment experience a variety of dreadful issues and comorbidities that involve medical, physical, and emotional aspects ( 4 , 5 ). One of the most prevalent comorbidity is cancer-related psychosocial distress ( 6 ).…”

Section: Introductionmentioning

confidence: 99%

Psychosocial distress and associated factors among adult cancer patients at oncology: a case of Ethiopia

Baye,

Bogale,

Delie

et al. 2023

Front. Oncol.

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BackgroundPsychosocial distress is a chronic burden for cancer survivors, which impacts both their quality of life and their oncologic prognosis. Although the national cancer prevention and control program in Ethiopia has made efforts in cancer prevention, control, and management by implementing the national cancer control plan 2016–2020, there was no enough evidence about psychosocial distress among adult cancer patients. So, it is critical to understand the magnitude of psychosocial distress and the factors that contribute to it.ObjectiveThe purpose of this study was to assess the prevalence of psychosocial distress and associated factors among adult cancer patients at oncology units in the Amhara regional state, Ethiopia. 2022.MethodsA multicenter institution-based cross-sectional study was conducted among a sample of 605 adult cancer patients from 30 April to 22 June 2022. A systematic random sampling technique was employed to select the study units. In addition, data were collected through interviewers administered questionnaires by using the validated and pretested tools. Distress was assessed using the Questionnaire on Stress in Cancer Patients Revised 10. Both bivariable and multivariable logistic regression was used to describe the association between dependent and independent variables. Independent variable with p < 0.25 in the bivariable logistic regression analyses were entered into multivariable logistic regression model. Variables with p < 0.05 in the multivariable logistic regression analyses were considered as statistically significant associated factors of psychosocial distress.ResultA total of 593 adult cancer patients took part in this study with mean age of 46.86 ± 14.5 years. The overall prevalence of psychosocial distress was 63.74%. Variables such as being female [AOR = 1.98, 95% confidence interval (CI): 1.24–3.17], patients who lives in rural areas (AOR = 2.3, 95% CI: 1.49–3.54), community-based health insurance utilization (AOR = 0.34, 95% CI: 0.23–0.51), patients on chemotherapy treatment (AOR = 2.72, 95% CI: 1.38–5.39), patients with comorbidity (AOR = 3.2, 95% CI: 1.67–6.10), and symptom burdens such as severe fatigue (AOR = 1.65, 95% CI:1.09–2.39) and severe nausea (AOR = 2.07, 95% CI: 1.43–3.00) were statistically associated with psychosocial distress.Conclusion and recommendationIn general, the findings of this study showed a relatively high magnitude in which around two-thirds of patients experienced psychosocial distress. It is better to establish and enforce the integration and coordination of psychosocial oncology service programs at national level with parallel guidelines and policies.

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Psychosocial distress and associated factors among adult cancer patients at oncology units in the Amhara regional state, Ethiopia, 2022

Baye

Bogale

Tegenaw

et al. 2022

Preprint

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Background Psychosocial distress is a long-term burden for cancer survivors, which has an impact on their quality of life and oncologic prognosis. Although the national cancer prevention and control program in Ethiopia has made efforts in cancer prevention, control, and management by implementing the national cancer control plan 2016–2020, no enough evidence about psychosocial distress among adult cancer patients. So it is critical to understand the magnitude of psychosocial distress and the factors that contribute to it. Objective To assess the prevalence of psychosocial distress and associated factors among adult cancer patients at oncology units in the Amhara regional state, Ethiopia. 2022. Methods A multi-center institutional based cross-sectional study was conducted among a sample of 605 adult cancer patients from April 30-June 22, 2022. A systematic random sampling technique was employed to select the study units. And data were collected through interviewers administered questionnaires by using the validated and pretested tools. Distress was assessed using the Questionnaire on Stress in Cancer Patients Revised 10. Both bivariable and multivariable logistic regression was used to describe the association between dependent and independent variables. Independent variable with p-value less than 0.25 in the bivariable logistic regression analyses were entered into multivariable logistic regression model. Variables with p-value < 0.05 in the multivariable logistic regression analyses were considered as statistically significant associated factors of psychosocial distress. Result A total of 593 adult cancer patients took part in this study with mean age of 46.86 ± 14.5 years. The overall prevalence of psychosocial distress was 63.74%. Variables such as being female (AOR = 1.98, 95% CI: 1.24–3.17), patients who lives in rural areas (AOR = 2.3, 95% CI: 1.49–3.54), community based health insurance utilization (AOR = 0.34, 95% CI: 0.23–0.51), patients on chemotherapy treatment (AOR = 2.72, 95% CI: 1.38–5.39), patients with comorbidity (AOR = 3.2, 95% CI: 1.67–6.10), and symptom burdens such as severe fatigue (AOR = 1.65, 95% CI:1.09–2.39) and severe nausea (AOR = 2.07, 95%CI: 1.43-3.00) were statistically associated with psychosocial distress. Conclusion and recommendation: In general, the findings of this study showed a relatively high magnitude in which around two-thirds of patients experienced psychosocial distress. It is better to establish and enforce the integration and coordination of psychosocial-oncology service programs at national level with parallel guidelines and policies.

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Symptoms and Symptom Management in Survivorship Patients

Cited by 3 publications

References 252 publications

The Effect of Pregabalin on Postoperative Pain in Patients Undergoing Abdominal Surgery under General Anesthesia

The Effect of Pregabalin on Postoperative Pain in Patients Undergoing Abdominal Surgery under General Anesthesia

Psychosocial distress and associated factors among adult cancer patients at oncology: a case of Ethiopia

Psychosocial distress and associated factors among adult cancer patients at oncology units in the Amhara regional state, Ethiopia, 2022

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