Symptoms and duration of the prodromal phase in parkinson's disease

Abstract

To investigate the duration of a prodromal phase before the onset of the classic symptoms of idiopathic Parkinson's disease, the authors conducted a retrospective case-control study of 60 patients with Parkinson's disease and 58 age- and sex-matched control subjects, covering the decade preceding the onset of classic Parkinson's disease. The symptoms were derived from files of the patients' general practitioners. Compared with control subjects, patients pre-Parkinson's disease had more central nervous system, psychologic, musculoskeletal, and cardiovascular (i.e., autonomic) symptoms. Patients pre-Parkinson's disease also made more visits to general practitioners and medical specialists. The results indicate that the onset of classic parkinsonism is frequently preceded by a prodromal phase lasting from 4-6 years.

Latencia diagnóstica en la enfermedad de Parkinson: Estudio en 200 pacientes de novo en un hospital público de Chile

“…De este modo, resulta fundamental la sospecha diagnóstica de la EP por parte de los médicos de AP. En sendos trabajos foráneos se constató que un porcentaje de pacientes fueron referidos al especialista luego de múltiples consultas 6,8 . La referencia desde la AP constituye un elemento responsable de incrementar la latencia Latencia en el diagnóstico de enfermedad de Parkinson -L. Lay-Son et al diagnóstica, en contraste con la resolución más expedita de la interconsulta proveniente desde la AS.…”

Depression in Parkinson's disease

“…This finding highlights the close and enigmatic relationship between depression and PD. Not only does PD increase the risk for depression, but as Nilsson and colleagues have shown in a previous paper (11), depression is in fact a risk factor for PD, and may be the presenting symptom in some PD cases (12). Thus, a common neurobiological factor may underlie both depression and PD, or depression may damage dopaminergic nigrostriatal neurons through yet unknown mechanisms.…”

Restoration of Mitochondrial Dysfunction in 6-Hydroxydopamine Induced Parkinson’s disease: a Complete Review

“…The hallmark clinical signs of PD are its motor triad: a pillrolling rest tremor, rigidity, bradykinesia/akinesia, internal tremor associated with anxiety, cramps, aches, pains, gait and postural disturbances with a loss of righting refl exes, unsteadiness, imbalance and falls, sialorrhea, dysarthria, visual and genitourinary dysfunction, sleep disturbances, sweating, seborrhea, edema, constipation, paresthesias, fatigue, and a decreased sense of smell [172][173][174][175].…”