Symptomatic unilateral submandibular gland aplasia

Unilateral Aplasia of the Submandibular Gland with Multiple Calcified Cervical Lymph Nodes: A Case Report and Review of the Litarutre

“…Salivary gland aplasia is frequently associated with other congenital defects, such as lacrimal gland agenesis, absence of lacrimal puncta, [4] 1894 Right (2) Abdel-Dayem [16] 1978 Left (3) Kubo et al [6] 1990 Right (4) Garcia-Consuegra et al [7] 1999 Left (5) Yılmaz et al [4] 2002 Right (6) Roh [8] 2006 Right (7) Srinivasan et al [5] 2006 Right (8) Suzuki et al [13] 2007 Right (9) Shipchandler and Lorenz [12] 2008 Left (10) Koo et al [9] 2009 Left (case 1) Right (case 1) (12) Gupta et al [11] 2009 Right (13) Yanir et al [14] 2009 Right (14) Yılmaz et al [15] 2009 Right (15) Gallego et al [10] 2009 Right ( orbital abnormalities, ectodermal dysplasia, and cleft lip and palate [1,[17][18][19][20][21]. Less frequently, it appears as an isolated phenomenon [2][3][4][5][7][8][9][10]. In the present case, aplasia was an isolated defect, and not associated with other congenital disorders.…”

“…Any of the glands may be involved; however, the absence of all four major salivary glands is the most frequently encountered pattern [1][2][3]. Unilateral aplasia of submandibular gland is an extremely rare disorder; only 15 cases have been reported in the medical literature to date [4][5][6][7][8][9][10][11][12][13][14][15][16]. Salivary gland aplasia may ocur in isolation or it may be associated with other ectodermal defects [1,[17][18][19][20][21].…”

“…Salivary gland aplasia may ocur in isolation or it may be associated with other ectodermal defects [1,[17][18][19][20][21]. Patients may be asymptomatic [4,5,14,22,23] or may suffer xerostomia, dysphagia, taste alterations, oral burning, or extensive dental caries [1,2,10,15,24,25].…”

Unilateral absence of submandibular gland secondary to stones. Aplasia versus early atrophy

“…Analysis of these abnormalities suggests that the aplasia of salivary glands likely results from a disturbance during fetal development of the first and second branchial arches, but the exact etiology is unknown. Unilateral submandibular gland aplasia is even rarer with less than ten cases reported in the literature (3)(4)(5)(6)(7)(8)(9)(10)(11)(12). The etiopathogenesis of isolated absence of a e753 major salivary gland without other developmental anomalies is still unclear.…”