Symptomatic recurrence of SARS-CoV-2 infection in healthcare workers recovered from COVID-19

Atıcı, Serkan; Ek, Ömer Faruk; Yi̇ldi̇z, M.; Şıkgenç, Mehmet Mahfuz; Güzel, Efraim; Soysal, Ahmet

doi:10.3855/jidc.14305

Cited by 7 publications

(6 citation statements)

References 8 publications

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“…Likewise, 10 studies were identified via citation searching. These 10 were sought for retrieval and then assessed for eligibility [ 12 , [21] , [22] , [23] , [24] , [25] , [26] , [27] , [28] , [29] , [30] , [31] , [32] , [33] , [34] , [35] , [36] , [37] , [38] , [39] , [40] , [41] , [42] , [43] , [44] , [45] , [46] , [47] , [48] , [49] , [50] , [51] , [52] , [53] , [54] , [55] , [56] , [57] , [58] , [59] , [60] , [61] , [62] , [63] , [64] , [65] , [66] , [67] , [68] , [69] , [70] , [71] , [72] , [73] , [74] , [75] , [76] , [77] , [78] , [79] , [80] , [81] , [82] , [83] , [84] , [85] , [86] , [87] , [88] ,…”

Section: Resultsmentioning

confidence: 99%

The mystery of COVID-19 reinfections: A global systematic review and meta-analysis

Dhillon¹,

Qamar²,

Gilani³

et al. 2021

Annals of Medicine and Surgery

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Background As the COVID-19 pandemic rages on, reports on disparities in vaccine roll out alongside COVID-19 reinfection have been emerging. We conducted a systematic review to assess the determinants and disease spectrum of COVID-19 reinfection. Materials and methods A comprehensive search covering relevant databases was conducted for observational studies reporting Polymerase Chain Reaction (PCR) confirmed infection and reinfection cases. A quality assessment tool developed by the National Institute of Health (NIH) for the assessment of case series was utilized. Meta-analyses were performed using RevMan 5.3 for pooled proportions of findings in first infection and reinfection with a 95% confidence interval (CI). Results Eighty-one studies reporting 577 cases were included from 22 countries. The mean age of patients was 46.2 ± 18.9 years and 179 (31.0%) cases of comorbidities were reported. The average time duration between first infection and reinfection was 63.6 ± 48.9 days. During first infection and reinfection, fever was the most common symptom (41.4% and 36.4%, respectively) whilst anti-viral therapy was the most common treatment regimen administered (44.5% and 43.0%, respectively). Comparable odds of symptomatic presentation and management were reported for the two infections. However, a higher Intensive Care Unit (ICU) admission rate was observed in reinfection compared to first infection (10 vs 3). Ten deaths were reported with respiratory failure being the most common cause of death (7/10 deaths). Conclusion Our findings support immunization practices given increased ICU admissions and mortality in reinfections. Our cohort serves as a guide for clinicians and authorities in devising an optimal strategy for controlling the pandemic. (249 words)

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Section: Resultsmentioning

confidence: 99%

The mystery of COVID-19 reinfections: A global systematic review and meta-analysis

Dhillon¹,

Qamar²,

Gilani³

et al. 2021

Annals of Medicine and Surgery

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“…Some studies reported that health-care workers who have intense and close contact with infected individuals can suffer from COVID-19 disease more than once. 1 Safe and effective COVID-19 treatments have yet to be developed, but vaccination is an effective strategy in stopping the spread of SARS-CoV-2. Several vaccines have become available for use in different parts of the world: Over 40 candidate vaccines are in human trials, and over 150 are in preclinical studies.…”

Section: Introductionmentioning

confidence: 99%

Comparison of immunogenicity and reactogenicity of inactivated SARS-CoV-2 vaccine (CoronaVac) in previously SARS-CoV-2 infected and uninfected health care workers

Soysal

Gönüllü²,

Karabayır

et al. 2021

Human Vaccines & Immunotherapeutics

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The effects of inactivated SARS-CoV-2 vaccine (CoronaVac) on previously naturally infected individuals are unknown. This study compared immunogenicity and reactogenicity of CoronaVac in once naturally infected health-care workers (HCWs) and uninfected HCWs. All HCWs were immunized with two doses of CoronaVac (600 U/0.5 ml) intramuscularly at a 28-day interval. Adverse reactions were obtained by web-based questionnaires or telephone calls seven days after each vaccine dose. Detection of antibody levels against the receptor-binding domain (RBD) of SARS-CoV-2 spike protein was done four weeks after the second dose of the vaccine. We enrolled 103 previously naturally infected and 627 uninfected HCWs. The mean time for vaccination after the first nasopharyngeal SARS-CoV-2 positivity was 64 days (range: 15–136 days) in previously naturally infected HCWs. Among the previously naturally infected HCWs, 41 (40%) were asymptomatic, 52 (50%) had mild upper respiratory tract infections, 10 (105) had pneumonia, and only 6 (5%) were hospitalized. Any reported adverse reactions, either from the first dose or the second dose of vaccine administration, did not differ between previously infected and uninfected HCWs. Anti-RBD antibody titers were obtained in 50 (51%) of 103 previously infected HCWs and 142 (23%) of 627 uninfected HCWs. Anti-RBD antibody titers were significantly higher in HCWs with a previous natural infection (median 1220 AU/ml, range: 202–10328 AU/mL) than in uninfected HCWs (median: 913 AU/ml, range: 2.8–15547 AU/mL, p = .032). CoronaVac administration was safe and may elicit higher antibody responses in previously naturally infected individuals.

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“…Seventy-two studies were determined to be of good quality while nine studies were of fair quality (S3 Table). Studies were primarily downgraded for unclear study objectives[63], incomplete case definition[16, 28, 48, 66, 67, 70, 77, 83], non-consecutive subject recruitment[19, 27, 30, 34, 38, 39, 44–46, 49, 71, 79, 80, 86, 90], incomparable subjects[79], inadequate length of follow-up[43, 63], inadequate description of statistical methods[39, 46, 80] and inadequate description of results[39, 78]. The most common cause for downgrading studies was non-consecutive recruitment which raised concerns that the included sample could be biased towards a more severe presentation or included more individuals undergoing routine screening.…”

Section: Resultsmentioning

confidence: 99%

The mystery of COVID-19 reinfections: A global systematic review and meta-analysis of 577 cases

Dhillon

Qamar

Irfan

et al. 2021

Preprint

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Background As the COVID-19 pandemic rages on, reports on disparities in vaccine roll out alongside reinfection and reactivation from previously recovered cases have been emerging. With newer waves and variants of COVID-19, we conducted a systematic review to assess the determinants and disease spectrum of COVID-19 reinfection. Methods A comprehensive search covering relevant databases was conducted for observational studies reporting Polymerase Chain Reaction (PCR) confirmed infection and reinfection cases. Quality assessment tool developed by the National Institute of Health (NIH) for assessment of case series was used. Meta-analyses were performed using RevMan 5.3 for pooled proportions of findings in first infection and reinfection with 95% confidence interval (CI). Results Eighty-one studies reporting 577 cases were included from 22 countries. The mean age of patients was 46.2±18.9 years with males accounting for 45.8% of the study population while 179 (31.0%) cases of comorbidities were reported. The average time duration between first infection and reinfection was 63.6±48.9 days. During first infection and reinfection, fever was the most common symptom (41.4% and 36.4%,respectively) whilst anti-viral therapy was the most common treatment regimen administered (44.5% and 43.0%, respectively). Overall, comparable odds of symptomatic presentation and management were reported in the two infections. However, a higher Intensive Care Unit (ICU) admission rate was observed in reinfection compared to first infection (10 vs 3). Ten deaths were reported with 565 patients fully recovering. Respiratory failure was the most common cause of death (7/10 deaths). Seventy-two studies were determined to be of good quality whilst nine studies were of fair quality. Conclusion As the first global-scale systematic review of its kind, our findings support immunization practices given increased ICU admissions and mortality in reinfections. Our cohort serves as a guide for clinicians and authorities for devising an optimal strategy for controlling the pandemic.

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Symptomatic recurrence of SARS-CoV-2 infection in healthcare workers recovered from COVID-19

Cited by 7 publications

References 8 publications

The mystery of COVID-19 reinfections: A global systematic review and meta-analysis

The mystery of COVID-19 reinfections: A global systematic review and meta-analysis

Comparison of immunogenicity and reactogenicity of inactivated SARS-CoV-2 vaccine (CoronaVac) in previously SARS-CoV-2 infected and uninfected health care workers

The mystery of COVID-19 reinfections: A global systematic review and meta-analysis of 577 cases

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