Symptomatic Rathke's Cleft Cyst With Cavernous Sinus Syndrome -Case Report-

Miyajima, Yoshiteru; Oka, Hiroyuki; Utsuki, Satoshi; Kawasaki, Koji; Sato, Kimitoshi; Fujii, Kiyotaka

doi:10.2176/nmc.47.576

Cited by 8 publications

(5 citation statements)

References 11 publications

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“…Imaging examinations usually indicate a lesion located in the sellar or suprasellar region. Rathke's cleft cyst is found in 12–33% of routine autopsies [1, 2]. Some RCCs grow progressively over time [1, 3], but few patients with RCCs have obvious clinical symptoms.…”

Section: Introductionmentioning

confidence: 99%

Diagnostic Significance of Intracystic Nodules on MRI in Rathke’s Cleft Cyst

Wang

Xiao²,

Yu³

et al. 2012

International Journal of Endocrinology

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Background and Purpose. To explore strategies for the diagnosis and treatment of Rathke's cleft cyst (RCC). Methods. The medical records of 24 patients with sellar RCC were retrospectively reviewed. Two patients had concomitant pituitary adenoma, 2 underwent transcranial surgery, and 22 underwent transsphenoidal surgery. The clinical features, especially the findings of intracystic nodules on MRI, were evaluated and compared with the pathological findings. Results. Preoperatively, only 2 patients were diagnosed with RCC or suspected RCC. Pre- and postoperative MRI images revealed 10 intracystic nodules in 9 (37.5%) patients. Two nodules had bull's eyelike changes. The signal intensity of the intracystic nodules varied on T1- and T2-weighted images. Not all nodules on T2-weighted images were visualized. Postoperative MRI revealed recurrence or residual lesion in 5 patients; none had new symptoms and a second surgery was not required. Conclusions. Identifying intracystic nodules is important in patients with sellar cystic lesions. Bull's eyelike change in an intracystic nodule on MRI, which is reported here for the first time, potentially might have value for confirming the diagnosis.

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Section: Introductionmentioning

confidence: 99%

Diagnostic Significance of Intracystic Nodules on MRI in Rathke’s Cleft Cyst

Wang

Xiao²,

Yu³

et al. 2012

International Journal of Endocrinology

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“…Individual case reports have documented RCC presenting with unilateral cavernous sinus syndrome [5] or transient trochlear nerve palsy [5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Rathke’s cleft cyst presenting as bilateral abducens nerve palsy

et al. 2009

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We present a patient with a Rathke's cleft cyst who presented with rapidly progressive bilateral 6th nerve palsy. A 20-year-old woman with a history of cleft palate, hypertension, and hydronephrotic kidneys presented with a one month history of headache, associated with dizziness and diplopia on horizontal gaze. Examination was significant for profound bilateral 6th nerve palsies. Magnetic resonance imaging showed a hypodense mass that filled the sella and compressed the right cavernous sinus without contacting the optic chiasm. Pituitary function was normal. An endoscopic, transnasal transsphenoidal resection of the lesion was performed; microscopic examination revealed a Rathke's cleft cyst. Surgical excision resulted in near complete resolution of the bilateral 6th nerve palsy. Rathke's cleft cysts are an unusual cause of bilateral sixth nerve palsy and represent a potential cause of cranial neuropathy.

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“…Although RCC are usually asymptomatic, they sometimes grow large enough to compress the surrounding structure and become symptomatic [5]. RCC manifest as headache, visual impairment or pituitary dysfunction [2,3]. We report a case of RCC manifesting as primary amenorrhea.…”

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confidence: 95%

“…Rathke's cleft cysts (RCC) are intrasellar or suprasellar cysts derived from the remnants of Rathke's pouch in the intermediate lobe region of the pituitary gland [1,2]. They are lined by a single layer of ciliated cuboidal or columnar epithelium including cilia and goblet cells, which secrete mucus into the cyst [3].…”

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confidence: 99%

A case of Rathke's cleft cyst presenting with amenorrhea

Park

Lee

Kim

et al. 2012

Korean J Obstet Gynecol

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A 28-year-old female presented with Rathke's cleft cysts (RCC) manifesting as primary amenorrhea and no development of secondary sexual characteristics. She had no symptoms of headache, visual disturbance, anosmia or galactorrhea.. The endocrinologic study demonstrated partial hypopituitarism. Magnetic resonance imaging revealed about 1.5 cm sized sellar and suprasellar cystic tumor, extending into the pituitary stalk. Its tentative diagnosis was benign pituitary cystic tumor, such as RCC. She underwent surgery by a transsphenoidal approach. Histological examination revealed a ciliated columnar epithelium those consistent with RCC. RCC is rarely symptomatic, but mechanical compression by the cyst or infl ammation itself causes headache, visual fi eld defects, or symptoms of pituitary dysfunction. The present case shows that RCC may manifest as hypogonadotropic hypogonadism.

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Symptomatic Rathke's Cleft Cyst With Cavernous Sinus Syndrome -Case Report-

Cited by 8 publications

References 11 publications

Diagnostic Significance of Intracystic Nodules on MRI in Rathke’s Cleft Cyst

Diagnostic Significance of Intracystic Nodules on MRI in Rathke’s Cleft Cyst

Rathke’s cleft cyst presenting as bilateral abducens nerve palsy

A case of Rathke's cleft cyst presenting with amenorrhea

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