Symptomatic Rathke's Cleft Cyst Coexisting with Central Diabetes Insipidus and Hypophysitis: Case Report.

Hama, Seiji; Arita, Kazunori; Tominaga, Atsushi; Yoshikawa, Mineka; Eguchi, Kuniki; Sumida, Masayuki; Inai, Kei; Nishisaka, Takashi; Kurisu, Kaoru

doi:10.1507/endocrj.46.187

Cited by 50 publications

(39 citation statements)

References 18 publications

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“…Presumably this inflammation spreads to the surrounding normal pituitary tissue, and is the main cause of secondary hypopituitarism. 5) Seven of our eight patients had disturbed ACTHcortisol axis, and one had simple hypocortisolemia. Therefore, the serum cortisol level had decreased in all patients.…”

Section: Discussionmentioning

confidence: 79%

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Clinicopathological and Endocrinological Study of Rathke's Cleft Cyst Manifesting as Hyponatremia

Ogawa

Tominaga

Ikeda³

2007

Neurol. Med. Chir.(Tokyo)

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Rathke's cleft cyst becomes symptomatic in a few cases. Increasing experience has identified previously unrecognized clinical effects including pituitary dysfunction. This study retrospectively investigated eight patients with Rathke's cleft cyst manifesting as hyponatremia and treated surgically with histological confirmation to clarify the mechanism of hyponatremia. All patients suffered from physical symptoms caused by the hyponatremia. All patients underwent magnetic resonance (MR) imaging and screening of pituitary hormones in addition to cortisol and thyroid hormones. All patients had cysts of more than 10 mm in diameter and MR imaging frequently showed irregularly thickened cyst wall. Histological examination disclosed various phases of inflammation and significant fibrosis. Endocrinological examination showed low concentrations of both serum cortisol in all eight patients and urinary cortisol in six of six patients examined. The major cause of hyponatremia was hypocortisolemia, induced by damage to the anterior pituitary gland.

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Section: Discussionmentioning

confidence: 79%

“…3,10) A few cases become symptomatic, and manifest as disturbed visual function due to increased intracystic contents. Sometimes sudden onset of severe headache 7,8) and/or endocrinological dysfunction 2,4,5,9,11,13) occur. The former symptoms are presumably due to leakage of cyst content into the CSF space or intracystic hemorrhage.…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological and Endocrinological Study of Rathke's Cleft Cyst Manifesting as Hyponatremia

Ogawa

Tominaga

Ikeda³

2007

Neurol. Med. Chir.(Tokyo)

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“…7) Only 13 cases of RCC with granulomatous change have been diagnosed by pathological examination (Table 1). 1,[4][5][6][8][9][10][11][12][13]16,18,20) Four cases showed xanthogranulomatous change (Cases 3, 4, 6, and 8) and 2 cases had ossification of the cyst wall (Cases 6 and 8). Another case of ossifying xanthogranuloma in the dermis was described as being secondary to a metaplastic process.…”

Section: Discussionmentioning

confidence: 99%

Rathke's Cleft Cyst With Xanthogranulomatous Change -Case Report-

Miyajima

Oka

Utsuki

et al. 2011

Neurol. Med. Chir.(Tokyo)

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Fig. 1 Computed tomography scans showing a solid intrasellar lesion appearing isodense with rod-like calcification (arrow). AbstractA 58-year-old man presented with a rare case of Rathke's cleft cyst (RCC) manifesting as headache and visual disturbance. Goldman's perimeter showed he had bitemporal hemianopia. Magnetic resonance imaging revealed a solid intrasellar lesion. He underwent surgery via a right pterional approach. The lesion was red, solid, and fibrous. Histological examination revealed a few columnar epithelial cells with poor cilia in a xanthogranulomatous lesion. Only 13 cases of RCC with granulomatous change have been diagnosed by pathological examination, including 4 xanthogranulomatous cases. Xanthogranuloma of the sellar region is relatively rare. The etiology is still unknown. We speculate that xanthogranulomas of the sellar region may be caused by reaction to the presence of RCC.

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“…There are few cases of XGI in the head and neck including periorbital region, Rathke cleft cyst and neuroenteric cyst at the cerebellopontine angle, presenting with pathologically analogue lesions [12][13][14].…”

Section: Discussionmentioning

confidence: 99%

Branchial Cleft Cyst with Xanthogranulomatous Inflammation

Sarıoğlu

Ünlü

Adalı

et al. 2011

Head and Neck Pathol

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Xanthogranulomatous inflammation (XGI) is a special type of inflammation presenting as mass lesions and mimicking malignant tumors. It is rarely described in the head and neck region, and to the best of our knowledge, there are no cases associated with branchial cleft cyst. A 39-year-old woman with an infiltrative cystic neck mass that radiologically mimicks a malignant tumor is herein presented. The histopathologic diagnosis was a branchial cleft cyst with XGI. XGI may be associated wih branchial cleft cysts. Patients may present with radiologic findings mimicking an invasive malignant tumor, and should be taken into account during the differential diagnosis with cystic squamous cell carcinoma.

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Symptomatic Rathke's Cleft Cyst Coexisting with Central Diabetes Insipidus and Hypophysitis: Case Report.

Abstract: Abstract.We

Cited by 50 publications

References 18 publications

Clinicopathological and Endocrinological Study of Rathke's Cleft Cyst Manifesting as Hyponatremia

Clinicopathological and Endocrinological Study of Rathke's Cleft Cyst Manifesting as Hyponatremia

Rathke's Cleft Cyst With Xanthogranulomatous Change -Case Report-

Branchial Cleft Cyst with Xanthogranulomatous Inflammation

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