Symptomatic non-parasitic cysts of the liver

Jones, William Lloyd; Mountain, John C.; Warren, Kenneth W.

doi:10.1002/bjs.1800610211

Cited by 88 publications

(35 citation statements)

References 23 publications

(16 reference statements)

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“…The second choice of treatment after percutaneous sclerotherapy has failed, comprises cyst wall deroofing [17] . This technique is indicated when a cyst recurs after percutaneous sclerotherapy with concomitant increase of abdominal complaints.…”

Section: Discussionmentioning

confidence: 99%

Results of percutaneous sclerotherapy and surgical treatment in patients with symptomatic simple liver cysts and polycystic liver disease

Erdogan

Delden²,

Rauws³

et al. 2007

WJG

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Section: Discussionmentioning

confidence: 99%

Results of percutaneous sclerotherapy and surgical treatment in patients with symptomatic simple liver cysts and polycystic liver disease

Erdogan

Delden²,

Rauws³

et al. 2007

WJG

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“…Both of these forms of PLD have an autosomal dominant pattern of inheritance [55] . There are various treatments for symptomatic hepatic cysts, such as cyst aspiration sclerotherapy [26,27,30,[35][36][37][38][39][40][41][42][43][44][45] , cyst fenestration (deroofing) [28,46] , liver resection [32][33][34]47] , hepatic arterial embolization [29] , and transplantation [31] . These treatments do not alter the natural course of the disease.…”

Section: Discussionmentioning

confidence: 99%

“…Surgery has been the traditional treatment for symptomatic hepatic cysts, but is quite invasive and has a relatively high incidence of complications [32][33][34]40] . The recurrence rate after liver resection has been reported to be 3% to 33% [56][57][58] .…”

Section: Discussionmentioning

confidence: 99%

Repeated Minocycline Hydrochloride Injections for Symptomatic Polycystic Liver Disease

Yoshida

Makino

Yokoyama

et al. 2016

Journal of Gastroenterology and Hepatology Research

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AIM:The present study evaluated the safety and effectiveness of repeated injections of minocycline hydrochloride (MINO) for symptomatic polycystic liver disease (PLD). METHODS:We retrospectively studied patients who received percutaneous MINO injections for symptomatic PLD and were followed up for at least 2 years between 2002 and 2015. Huge hepatic cysts (diameter > 10 cm) were treated by continuous drainage and multiple MINO injections. Small hepatic cysts underwent one-step drainage followed by a single injection of MINO. Only several cysts that caused complications were treated by percutaneous injection of MINO. Patients were discharged 1 day after treatment. RESULTS: Ten patients, (4men and 6 women; mean age, 57.8 years) were studied. All patients had Type 2 PLD according to Gigot's classification. The chief complaints were abdominal distension (n = 10), abdominal pain (n = 6), back pain (n = 4), and appetite loss (n = 8). Four patients had mild liver dysfunction. One patient complained of moderate right subscapular pain immediately after the injection, and another had pain at the site of catheter insertion. Liver dysfunction did not develop in any patient after treatment. The mean follow-up was 63.4 months. The interval from the first to last admission for MINO injection therapy was 14 to 148 months (mean, 40.8 months). The number of admissions for MINO injection therapy ranged from 2 to 12 times (mean, 4.0 times). The average interval for MINO injection therapy was 8.3 to 19 months (mean, 14.8 months).The hepatic cysts shrank in all patients after treatment. Complications improved consistently, and all patients were satisfied with the outcome of treatment. CONCLUSIONS: Symptomatic PLD was controllable by 14.8 months of repeated MINO injections on average. Repeated MINO injections are a safe, definitive treatment for symptomatic PLD.

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“…Most patients with hemorrhagic cysts presented with abdominal pain (80%), while 14% of the patients were asymptomatic at presentation. Treatment recommendations for symptomatic hepatic cysts include surgery [28][29][30] and the injection of a sclerosing agent into the cyst [31][32][33]. The clinical presentation of spontaneous intracystic hemorrhage usually begins with severe abdominal pain of sudden onset, followed by a gradual decline in pain and healing in response to conservative therapy [10,12,13,34].…”

Section: Discussionmentioning

confidence: 99%

An Asymptomatic Hemorrhagic Hepatic Cyst with Solid Contents

Kondo¹,

Yoshida²,

Hirakata³

et al. 2014

Int J Gastroenterol Disord Ther

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We describe a patient who had an asymptomatic hemorrhagic hepatic cyst with solid contents that mimicked a malignancy. An 85-year-old woman was referred to our hospital because a hypoechoic mass was detected. She had no complications. The past medical history included hypertension and left femoral artery aneurysm. The results of initial laboratory tests were as follows: serum aspartate aminotransferase, 28 IU/L; serum alanine aminotransferase, 23 IU/L; serum C-reactive protein, 0.11 mg/dL; and serum hemoglobin concentration, 13.1 g/dL. The serum platelet count (17.3×104/μL) was slightly decreased. The serum concentration of carcinoembryonic antigen was 3.0 ng/mL, that of CA19-9 was 12.2 u/ml, and that of AFP was 3.8 ng/ml. The serum concentration of hyaluronic acid (147 ng/mL) was elevated. Hepatitis B virus antigen and hepatitis C virus antibody were negative. Ultrasonography revealed a protruding hypoechoic mass, 6 cm in diameter, with a central isoechoic structure in segment 7, accompanied by multiple hepatic cysts. The edge of the liver was dull, and the liver parenchymal echo was mildly rough. Computed tomography (CT) showed a slightly high-density area with calcification of the margin. Magnetic resonance imaging revealed a hypointense lesion with central hyperintensity on T1-weighted sequences and hyperintensity on T2-weighted sequences. On positron emission tomography-CT, there was no uptake of fluorodeoxyglucose in the liver. We diagnosed an old hemorrhagic cyst or abscess, but could not rule out a malignant neoplasm because of the damaged liver. A right lateral sectionectomy was therefore performed. The resected specimen had black solid contents, and the capsule lacked fluid. Pathological examination revealed an old hemorrhage with a thick fibrous capsule without epithelial components. The liver showed mild fibrosis with fatty changes. The lesion was considered an old hemorrhagic hepatic cyst because a nearby hepatic cyst had simple columnar epithelium.

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Symptomatic non-parasitic cysts of the liver

Abstract: Eighteen patients with symptomatic non-parasitic cysts of the liver were seen and treated at the Lahey Clinic Foundation between 1950 and1970.

Cited by 88 publications

References 23 publications

Results of percutaneous sclerotherapy and surgical treatment in patients with symptomatic simple liver cysts and polycystic liver disease

Results of percutaneous sclerotherapy and surgical treatment in patients with symptomatic simple liver cysts and polycystic liver disease

Repeated Minocycline Hydrochloride Injections for Symptomatic Polycystic Liver Disease

An Asymptomatic Hemorrhagic Hepatic Cyst with Solid Contents

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