Symptomatic management in multiple sclerosis

Shah, Pushkar

doi:10.4103/0972-2327.164827

Cited by 15 publications

(9 citation statements)

References 83 publications

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“…For MS patients, LUTD is sustained by a complex alteration of the neurological control of the detrusor-sphincter function, resulting in detrusor over activity, detrusor hypocontractility, and/or DSD. [ 5 ] The results of the present study suggest that major patients with a diagnosis of MS present have urinary symptoms. DasGupta and Fowler reported that approximately 75% of all MS patients would develop voiding dysfunction and LUTS during the disease.…”

Section: Discussionmentioning

confidence: 56%

“…[ 4 ] LUTD is sustained by a complex alteration of the neurological control of the detrusor-sphincter function, resulting in detrusor overactivity, detrusor hypocontractility, and/or detrusor-sphincter dyssynergia (DSD). [ 5 ] For MS patients, LUTD not only seriously affects the quality of life but also leads to the increasing risk for the upper urinary tract. [ 6 7 ] MS is divided into three subtypes according to the history and clinical characteristics: Clinically isolated syndrome (CIS), relapsing-remitting, and primary progressive and secondary progressive.…”

Section: Introductionmentioning

confidence: 99%

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Clinical Characteristics and Urodynamic Analysis of Urinary Dysfunction in Multiple Sclerosis

Wang

Huang

Zhang

2016

Chinese Medical Journal

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Background:Both lower urinary tract dysfunction and urinary symptoms are prevalent in patients with multiple sclerosis (MS). Although the significance of identifying and treating urinary symptoms in MS is currently well-known, there is no information about the real prevalence and therapeutic effect of urinary symptoms in patients with MS. The purpose of this study was to analyze the major symptoms and urodynamic abnormalities, and observe the therapeutic effect in different MS characteristics.Methods:We enrolled 126 patients with urological dysfunction who were recruited between July 2008 and January 2015 in Beijing Tian Tan Hospital, Capital Medical University and conducted overactive bladder system score (OABSS), urodynamic investigation, and expanded disability status scale (EDSS). Changes of urinary symptoms and urodynamic parameters were investigated.Results:Urgency was the predominant urinary symptom, and detrusor overactivity was the major bladder dysfunction. There was a positive correlation between EDSS and OABSS. Clinically isolated syndrome (CIS) had lowest EDSS and OABSS. CIS exhibited significant improvements in OABSS, maximum urinary flow rate (Qmax), and bladder volume at the first desire to voiding and maximum bladder volume after the treatment (P < 0.05). Relapsing–remitting MS showed significant improvements in the OABSS, Qmax, and bladder volume at the first desire to voiding, maximum bladder volume and bladder compliance after the treatment (P < 0.05). Progressive MS exhibited significant increase in the bladder volume at the first desire to voiding, the detrusor pressure at maximum flow rate (PdetQmax), and bladder compliance after the treatment (P < 0.05).Conclusions:Urodynamic parameters examined are important in providing an accurate diagnosis, guiding management decisions of MS. Early and effective treatment may improve the bladder function and the quality of life at the early stages of MS.

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Section: Discussionmentioning

confidence: 56%

Section: Introductionmentioning

confidence: 99%

Clinical Characteristics and Urodynamic Analysis of Urinary Dysfunction in Multiple Sclerosis

Wang

Huang

Zhang

2016

Chinese Medical Journal

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“…Наприклад, такі симптоми, як біль, втома чи нетримання сечі, чинять вагомий вплив на повсякденне життя. Тому належне симптоматичне лікування може покращувати якість життя пацієнтів із РС якомога довше [16].…”

Section: симптоматичне лікування та реабілітаціяunclassified

Розсіяний Склероз В Україні

2023

UMJ

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Анотація. Розсіяний склероз (РС) -хронічне аутоімунне демієлінізуюче захворювання центральної нервової системи, яке є однією з найпоширеніших причин прогресуючої інвалідності, особливо серед осіб молодого віку. Це, у свою чергу, чинить негативний вплив як на пацієнтів, так і на осіб, що за ними доглядають. Крім того, загальне фінансове навантаження на суспільство збільшується в міру накопичення інвалідності. На сьогодні підвищилася обізнаність про РС, стали доступними більш ефективні методи терапії, зібрано значну кількість статистичних даних щодо епідеміології, діагностики та лікування РС в Україні та світі. У статті систематизовано відомі епідеміологічні дослідження щодо РС в Україні, зокрема з використанням 3-го видання «The Multiple Sclerosis International Federation (MSIF) Atlas of MS». Чітке розуміння тенденцій та основних факторів, що впливають на розвиток і прогресування РС в Україні, а також знання про перешкоди для доступу до лікування чи реабілітації пацієнтів із РС, мають важливе значення для оптимального клінічного менеджменту та вдосконалення системи охорони здоров'я в нашій країні.

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“…The disease manifests through symptoms such as overall physical disability, imbalance of gait, sensory disturbance and cognitive dysfunction, the factor causing this disease are unknown [50, 51]. MRI imaging plays an important role in early diagnosis of MS and in monitoring treatment efficacy; however, the technique shows low pathological specificity and low sensitivity to diffuse damage in normal-appearing white matter (NAWM) and gray matter (NAGM) [52].…”

Section: Applications Of Dti Of Brainmentioning

confidence: 99%

Recent Developments in Diffusion Tensor Imaging of Brain

Parekh¹,

Gurjarpadhye²,

Manoukian³

et al. 2016

Radiol Open J

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Citation ABSTRACTMagnetic Resonance Imaging (MRI) has come to be known as a unique radiological imaging modality because of its ability to perform tomographic imaging of body without the use of any harmful ionizing radiation. The radiologists use MRI to gain insight into the anatomy of organs, including the brain, while biomedical researchers explore the modality to gain better understanding of the brain structure and function. However, due to limited resolution and contrast, the conventional MRI fails to show the brain microstructure. Diffusion Tensor Imaging (DTI) harnesses the power of conventional MRI to deduce the diffusion dynamics of water molecules within the tissue and indirectly create a three-dimensional sketch of the brain anatomy. DTI enables visualization of brain tissue microstructure, which is extremely helpful in understanding various neuropathologies and neurodegenerative disorders. In this review, we briefly discuss the background and operating principles of DTI, followed by current trends in DTI applications for biomedical and clinical investigation of various brain diseases and disorders.

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Symptomatic management in multiple sclerosis

Cited by 15 publications

References 83 publications

Clinical Characteristics and Urodynamic Analysis of Urinary Dysfunction in Multiple Sclerosis

Clinical Characteristics and Urodynamic Analysis of Urinary Dysfunction in Multiple Sclerosis

Розсіяний Склероз В Україні

Recent Developments in Diffusion Tensor Imaging of Brain

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