Symptomatic graft failure and impact on clinical outcome after coronary artery bypass grafting surgery: Results from the Alberta Provincial Project for Outcome Assessment in Coronary Heart Disease registry

Shavadia, Jay; Norris, Colleen M.; Graham, Michelle M.; Verma, Subodh; Ali, Imtiaz S.; Bainey, Kevin R.

doi:10.1016/j.ahj.2015.02.022

Cited by 35 publications

(17 citation statements)

References 29 publications

(26 reference statements)

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“…[2] Unfortunately, even standard treatments, such as autologous vein grafts from the leg or arterial grafts from the arm or thorax, commonly fail within a few years due to inappropriate vessel remodeling. [3] These graft failures are primarily driven by maladaptive cellular responses elicited by tissue injury and hemodynamic stress. [4] Anastomoses, the sites of surgical vessel connection, are at particular risk due to suture line scarring, stricture, and higher incidences of stenosis and fibrosis.…”

Section: Introductionmentioning

confidence: 99%

Attenuation of Maladaptive Responses in Aortic Adventitial Fibroblasts through Stimuli‐Triggered siRNA Release from Lipid–Polymer Nanocomplexes

et al. 2017

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Lipid-siRNA assemblies are modified with photo-responsive polymers to enable spatiotemporally-controlled silencing of interleukin 1 beta (IL1β) and cadherin 11 (CDH11), two genes that are essential drivers of maladaptive responses in human aortic adventitial fibroblasts (AoAFs). These hybrid nanocomplexes address the critical challenge of locally mitigating fibrotic actions that lead to the high rates of vascular graft failures. In particular, the lipid-polymer formulations provide potent silencing of IL1β and CDH11 that is precisely modulated by a photo-release stimulus. Moreover, a dynamic modeling framework is used to design a multi-dose siRNA regimen that sustains knockdown of both genes over clinically-relevant timescales. Multi-dose suppression illuminates a cooperative role for IL1β and CDH11 in pathogenic adventitial remodeling and is directly linked to desirable functional outcomes. Specifically, myofibroblast differentiation and cellular proliferation, two of the primary hallmarks of fibrosis, are significantly attenuated by IL1β silencing. Meanwhile, the effects of CDH11 siRNA treatment on differentiation become more pronounced at higher cell densities characteristic of constrictive adventitial remodeling in vivo. Thus, this work offers a unique formulation design for photo-responsive gene suppression in human primary cells and establishes a new dosing method to satisfy the critical need for local attenuation of fibrotic responses in the adventitium surrounding vascular grafts.

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Section: Introductionmentioning

confidence: 99%

Attenuation of Maladaptive Responses in Aortic Adventitial Fibroblasts through Stimuli‐Triggered siRNA Release from Lipid–Polymer Nanocomplexes

et al. 2017

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“…Data regarding the clinical consequences of graft closure are inconsistent. Although it has been suggested that it leads to repeat revascularization rather than hard endpoints, other authors suggest graft failure mostly presents with acute coronary syndromes . Occluded vein grafts are generally considered very unattractive targets for PCI with relatively poor short and long‐term outcomes .…”

Section: Discussionmentioning

confidence: 99%

Invasive angiography and revascularization in patients with stable angina following prior coronary artery bypass grafting: Results from the East Denmark heart registry

Joshi

Biasco

Pedersen

et al. 2016

Cathet Cardio Intervent

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“…По данным ряда авторов, диффузный характер поражения венечных артерий и мелкий диаметр (менее 1,5 мм) яв-ляются независимыми предикторами плохих результатов, операционной и госпитальной смертности [50].…”

Section: тактика операцииunclassified

Modern trends in coronary surgery

Акчурин¹,

Shiryaev²,

Vasiliev³

et al. 2017

PKiK

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Based on their 30-year experience, the authors discuss the most important problems in coronary surgery. The modern view on the indications for surgery, as well as on patients selection is presented in the light of the most recent and complete studies. The authors also present the modern approach to surgical technique, choice of graft and describe opportunities offered by microsurgical technique.Received 30 June 2017. Accepted 10 July 2017.Funding: The study did not have sponsorship.Conflict of interest: The authors declare no conflict of interests.

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Symptomatic graft failure and impact on clinical outcome after coronary artery bypass grafting surgery: Results from the Alberta Provincial Project for Outcome Assessment in Coronary Heart Disease registry

Cited by 35 publications

References 29 publications

Attenuation of Maladaptive Responses in Aortic Adventitial Fibroblasts through Stimuli‐Triggered siRNA Release from Lipid–Polymer Nanocomplexes

Attenuation of Maladaptive Responses in Aortic Adventitial Fibroblasts through Stimuli‐Triggered siRNA Release from Lipid–Polymer Nanocomplexes

Invasive angiography and revascularization in patients with stable angina following prior coronary artery bypass grafting: Results from the East Denmark heart registry

Modern trends in coronary surgery

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