Symptomatic Diverticulosis Is Characterized By Loose Stools

Jarbrink-Sehgal, Maria; Andréasson, Anna; Talley, Nicholas J.; Agréus, Lars; Song, Jeong-Yeop; Schmidt, Peter T.

doi:10.1016/j.cgh.2016.06.014

Cited by 32 publications

(28 citation statements)

References 31 publications

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“…Among patients with CD, about 10% had inflammatory findings. Some reports (including ours) showed a relationship between CD and diarrhea . Initially, we supposed that patients with inflammatory findings had diarrhea; however, this study showed no such association.…”

Section: Discussioncontrasting

confidence: 72%

“…Some reports (including ours) showed a relationship between CD and diarrhea. [22][23][24] Initially, we supposed that patients with inflammatory findings BSD, bilateral-sided diverticula; LSD, left-sided diverticula; NSAID, nonsteroidal anti-inflammatory drug; RSD, right-sided diverticula; SD, standard deviation. had diarrhea; however, this study showed no such association.…”

Section: Colonic Diverticula and Bowel Habitsmentioning

confidence: 99%

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Association between endoscopic findings related to colonic diverticula and bowel habits: A multicenter study in Japan

Yamada¹,

Kuriyama²,

Uchida³

et al. 2017

J of Gastro and Hepatol

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Among endoscopic findings related to colonic diverticula and bowel habits, only left-sided colonic diverticula were inversely associated with constipation, whereas inflammation findings, multiple diverticula, and sigmoid colon rigidity were not related to bowel habits. However, the association of inflammation findings with colonic diverticula and bowel habits should be further studied. Investigation of changes in left-sided colonic diverticula may lead to new treatments for constipation.

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Section: Discussioncontrasting

confidence: 72%

Section: Colonic Diverticula and Bowel Habitsmentioning

confidence: 99%

Association between endoscopic findings related to colonic diverticula and bowel habits: A multicenter study in Japan

Yamada¹,

Kuriyama²,

Uchida³

et al. 2017

J of Gastro and Hepatol

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“…As a consequence, several authors still talk about "IBS with diverticulosis." For example, Jung et al [7] found that IBS occurs 4.7-fold more likely in patients after an episode of acute diverticulitis than controls and, more recently, Järbrink-Sehgal et al [8] found that diverticulosis was associated with diarrhea-predominant IBS (OR, 9.55; 95% CI, 1.08-84.08; p = 0.04).…”

Section: Inflammationmentioning

confidence: 99%

“…European countries with a lower socioeconomic status report a 5.3% frequency of diverticulosis in patients aged [30][31][32][33][34][35][36][37][38][39]8.7% in those aged [40][41][42][43][44][45][46][47][48][49]19.4% between 50 and 59, and up to 29.6% in subjects over the seventh decade, while maximal incidences were found in patients aged 70-79 and above 80 of 40.2 and 57.9%, respectively [2].…”

Section: Introductionmentioning

confidence: 99%

The Pathophysiology of Colonic Diverticulosis: Inflammation versus Constipation?

Elisei¹,

Tursi²

2018

Inflamm Intest Dis

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Background: Diverticulosis of the colon is the most common anatomic alteration of the human colon, but the pathophysiologic mechanisms of its occurrence are not completely understood. Summary: Constipation has been considered the key factor for diverticulosis occurrence. However, several fine papers questioned this pathogenetic hypothesis, showing on the contrary an inverse relationship between low number of bowel movements and diverticulosis occurrence. In the last years, several papers have showed the role of low-grade inflammation in the occurrence of symptoms in people having diverticulosis, as well as its role on symptom persistence following acute diverticulitis, even if the evidence available is not so strong. Although the trigger of this low-grade inflammation is currently under debate, some preliminary evidence found colonic dysbiosis linked to symptom occurrence in those patients. Key Messages: Constipation no longer seems the leading cause for diverticulosis occurrence, while low-grade inflammation could play a role in symptom occurrence.

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“…While for most this is a harmless ageing change reflecting weakening of colonic connective tissue, around 30% suffer recurrent abdominal pain, often with diarrhoea,2 and 1–4% will be hospitalised with diverticulitis 3. As our population steadily ages this represents a substantial health burden, however, we know surprisingly little about the underlying mechanisms of this disease.…”

mentioning

confidence: 99%

Do diverticula provide a unique niche for microbiota which can lead to activation of the innate immune system?

Spiller

Sloan

2016

Gut

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Symptomatic Diverticulosis Is Characterized By Loose Stools

Cited by 32 publications

References 31 publications

Association between endoscopic findings related to colonic diverticula and bowel habits: A multicenter study in Japan

Association between endoscopic findings related to colonic diverticula and bowel habits: A multicenter study in Japan

The Pathophysiology of Colonic Diverticulosis: Inflammation versus Constipation?

Do diverticula provide a unique niche for microbiota which can lead to activation of the innate immune system?

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