Symptomatic diffuse adenomyomatosis of the gallbladder with subserosal inflammatory sclerolipomatosis: Imaging findings

Coulier, B; Gielen, Isabelle; Ramboux, A.; Broeck, S Van den

doi:10.1016/j.diii.2015.09.003

Cited by 1 publication

(2 citation statements)

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“…GA, or adenomyomatous hyperplasia, is a benign hyperplasia of the gallbladder wall and is a relatively common lesion, accounting for 9% of cholecystectomy specimens [ 5 , 6 ]. It is most predominantly found in women in their 50s with the majority presenting with complaints of chronic right upper quadrant pain or with leucocytosis of atypical acute cholecystitis [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

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Diffuse Gallbladder Adenomyomatosis in a Child

Pham¹,

Xuan²,

Dang³

2021

Cureus

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Adenomyomatosis of the gallbladder is a benign condition, usually occurring in middle age, in which the epithelium of the gallbladder proliferates and the gallbladder wall thickens with the presence of Rokitansky-Aschoff sinuses (RAS). The diffuse form is an unusual subtype of adenomyomatosis. Herein, we describe a 17-year-old female who presented with dull and intermittent pain in the right hypochondriac region for more than a month. Ultrasound followed by magnetic resonance imaging showed marked diffuse gallbladder wall thickening. A gross cholecystectomy specimen showed a diffusely enlarged gallbladder. The final diagnosis of gallbladder adenomyomatosis (GA) was confirmed by the histopathologic appearance of muscular and epithelial hyperplasia, contributing to mural thickening with epithelial invaginations forming the pathognomonic intramural diverticula known as the RAS. This case highlights that the diffuse form of GA is uncommon and is often accompanied by chronic inflammation, sometimes requiring differential diagnosis from gallbladder malignancies, especially when there is no image showing a “comet tail” of cholesterol crystals in the wall.

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Section: Discussionmentioning

confidence: 99%

“…Although GA is not considered a risk factor for malignancy, resection is usually indicated in symptomatic cases, in the presence of acute inflammation, in the presence of stones, in secondary inflammation that may lead to dysplasia, and when it is difficult to distinguish GA from other malignancies of the gallbladder [ 7 ].…”

Section: Discussionmentioning

confidence: 99%